Drotaverine 80mg + Aceclofenac 100 mg

Category- Allopathy

About Drotaverine 80mg + Aceclofenac 100 mg

Drotaverine 80 mg + Aceclofenac 100 mg is a combination medicine used to relieve painful muscle spasms and inflammation. It is commonly used for abdominal cramps, menstrual pain, muscle pain, joint pain, kidney stone pain, and gallbladder pain. 

Drotaverine helps relax the smooth muscles and reduce spasms, while Aceclofenac helps reduce pain, swelling, and inflammation. Common side effects include nausea, stomach pain, acidity, dizziness, diarrhea, and headache. 

Rare but serious side effects may include stomach ulcer or bleeding, severe allergy, liver problems, kidney problems, and severe skin reactions. Overall, this medicine helps provide relief from pain and cramp-related discomfort by relaxing muscles and reducing inflammation.

Medicine Highlights

Drotaverine 80mg + Aceclofenac 100 mg Uses

Drotaverine 80mg + Aceclofenac 100 mg is used to treat the following conditions: 

1. Abdominal pain due to stomach or intestinal spasms 
2. Menstrual cramps and pelvic pain 
3. Muscle pain and spasms 
4. Joint pain and inflammation 
5. Pain due to kidney stones (renal colic) 
6. Pain due to gallbladder stones (biliary colic)    

Drotaverine 80mg + Aceclofenac 100 mg side effects 

More Common

1. Nausea 
2. Vomiting 
3. Stomach pain 
4. Acidity or indigestion 
5. Diarrhea 
6. Dizziness 
7. Headache 
8. Weakness or tiredness      

Less Common 

1. Stomach ulcer or bleeding (black stools, vomiting blood, severe stomach pain) 
2. Severe allergic reactions (rash, swelling, breathing difficulty) 
3. Liver problems (yellow skin or eyes, dark urine) 
4. Kidney problems (swelling, reduced urine output) 
5. Skin rash or severe skin reactions  

How Drotaverine 80mg + Aceclofenac 100 mg works 

This combination works in two ways to relieve pain and spasms. Drotaverine is an antispasmodic medicine that relaxes smooth muscles in organs such as the stomach, intestines, uterus, and urinary tract, helping reduce cramps and spasms. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that blocks chemicals responsible for pain and inflammation. Together, they help reduce crampy pain, swelling, stiffness, and muscle spasms. 

Safety Measures and Warning 

Allergy/Hypersentivity

If you are allergic to Drotaverine, Aceclofenac, or any NSAID medicine, avoid using this medicine because it may cause serious allergic reactions like rash, swelling, itching, or breathing difficulty.

Stomach Ulcer or Bleeding

Use this medicine carefully if you have a history of stomach ulcers or bleeding because Aceclofenac may worsen these conditions.

Liver disease

Inform your doctor if you have liver disease because this medicine may affect liver function and require dose adjustment.

Kidney disease

Patients with kidney disease should use this medicine cautiously because it may worsen kidney function.

Heart Disease

People with heart disease or high blood pressure should consult their doctor before taking this medicine because NSAIDs may increase cardiovascular risks.

Pregnancy and Breastfeeding

This medicine should only be used during pregnancy or breastfeeding if advised by a doctor. Avoid using it during the last trimester of pregnancy. 

Drotaverine 80mg + Aceclofenac 100 mg Interaction with Food Product 

Taking this medicine after meals may help reduce stomach irritation. Avoid alcohol while taking this medicine because it may increase the risk of stomach bleeding, acidity, and dizziness.

Drotaverine 80mg + Aceclofenac 100 mg Interaction with Other Medicines  

Avoid taking Drotaverine 80mg + Aceclofenac 100 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Drotaverine 80mg + Aceclofenac 100 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Drotaverine: (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline

Aceclofenac: 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid 

Intake routine/cycle

Daily dose

Take Drotaverine 80mg + Aceclofenac 100 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Drotaverine 80mg + Aceclofenac 100 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Drotaverine 80mg + Aceclofenac 100 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Drotaverine 80mg + Aceclofenac 100 mg, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

FAQ’s

1. What are the uses of aceclofenac 100mg & drotaverine hydrochloride 80mg? 

A: Aceclofenac 100mg & drotaverine hydrochloride 80mg is used to relieve pain, swelling, and inflammation in conditions such as muscle pain, joint pain, arthritis, back pain, dental pain, injury pain, and pain after surgery.

Reference  

1. PubChem. Drotaverine [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Feb 26]. Available from 
2. Drotaverine [Internet]. go.drugbank.com. Available from 
3. PubChem. Aceclofenac [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
4. Aceclofenac [Internet]. go.drugbank.com. Available from 
5. Aceclofenac 100 mg Film-coated Tablets – Summary of Product Characteristics (SmPC) – (emc) | 2389 [Internet]. Medicines.org.uk. 2023 [cited 2025 Jul 25]. Available from 
6. Medicover Hospitals. Aceclofenac | Side Effects | Dosage | Precautions | Medicine [Internet]. Medicoverhospitals.in. 2021. Available from  

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.