Category- Allopathy
About Mefenamic acid 50mg + Paracetamol 125mg/5ml
Mefenamic Acid 50 mg + Paracetamol 125 mg/5 ml syrup is an analgesic medicine. Mefenamic acid 50mg + Paracetamol 125mg/5ml is used mainly in children to reduce fever, relieve mild to moderate pain, and decrease inflammation. It works by lowering body temperature and blocking pain signals in the brain (Paracetamol), while also reducing the production of chemicals called prostaglandins that causes pain and swelling (Mefenamic Acid).
Mefenamic acid 50mg + Paracetamol 125mg/5ml should be given only as prescribed by a doctor, based on the child’s age and weight. It should be taken after food to avoid stomach irritation, and overdose must be strictly avoided as it can cause serious liver damage, stomach ulcers, bleeding, or kidney problems. Common side effects of Mefenamic acid 50mg + Paracetamol 125mg/5ml are nausea, vomiting, stomach pain, diarrhea, dizziness, and loss of appetite, and medical help should be sought if any severe symptoms occur.
Medicine Highlights
| Uses | 1. To treat fever in children 2. To treat mild to moderate pain 3. To treat headache 4. To treat toothache 5. To treat body pain due to infections 6. To treat muscle pain 7. To reduce inflammation (swelling and pain) |
| Common Side Effects | 1. Nausea 2. Vomiting 3. Stomach pain 4. Diarrhea 5. Indigestion 6. Dizziness 7. Loss of appetite |
| Additional Information | This medicine should only be used under medical supervision. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this syrup orally with a sip of water |
Mefenamic acid 50mg + Paracetamol 125mg/5ml Uses
Mefenamic Acid 50 mg + Paracetamol 125 mg/5 ml is a combination pain-relieving and fever-reducing medicine that belongs to the class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) along with an antipyretic (Paracetamol). Mefenamic acid 50mg + Paracetamol 125mg/5ml syrup is used to treat symptoms of conditions like:
- Fever
- Headache
- Toothache
- Muscle pain
- Body pain due to infections
- Mild to moderate pain in children
Mefenamic acid 50mg + Paracetamol 125mg/5ml side effects
More Common
- Nausea
- Vomiting
- Stomach pain
- Diarrhea
- Indigestion
- Dizziness
- Loss of appetite
Less Common
- Severe stomach pain
- Liver problems (yellowing of skin or eyes)
- Allergic reaction (rash, itching, swelling)
- Breathing difficulty
- Stomach ulcer or bleeding (black stools, blood in vomit)
- Kidney problems (reduced urine output)
How Mefenamic acid 50mg + Paracetamol 125mg/5ml works
Mefenamic Acid 50 mg + Paracetamol 125 mg/5 ml syrup works by mainly, Paracetamol works mainly in the brain to lower body temperature and reduce the feeling of pain. Mefenamic Acid works by blocking certain chemicals in the body (prostaglandins) that cause pain, swelling, and fever. When these chemicals are reduced, the child experiences less pain and discomfort. Together, both medicines provide better and faster relief from fever and mild to moderate pain.
Safety Measures and Warning
Allergy / Hypersensitivity
If you are allergic to Mefenamic acid 50mg + Paracetamol 125mg/5ml, this can cause serious allergic reactions such as skin rash, itching, swelling of the face or throat, breathing difficulty, or severe reactions. Hence, inform your doctor if you have any history of allergy to painkillers before taking this medicine.
Stomach Ulcer or Bleeding
If you have a history of stomach ulcers or bleeding, taking Mefenamic Acid can increase the risk of severe stomach pain, ulcers, or internal bleeding. Hence, inform your doctor before using Mefenamic acid 50mg + Paracetamol 125mg/5ml.
Kidney Disease
If you have kidney problems, Mefenamic acid 50mg + Paracetamol 125mg/5ml may worsen kidney function and reduce urine output. Hence, inform your doctor so the dose can be adjusted or avoided if necessary.
Liver Disease
If you have liver disease, Mefenamic acid 50mg + Paracetamol 125mg/5ml may affect liver function and cause complications. Hence, inform your doctor before taking it.
Heart Problems
If you have heart disease or high blood pressure, Mefenamic acid 50mg + Paracetamol 125mg/5ml may increase the risk of heart-related complications. Hence, inform your doctor before use.
Asthma
If you have asthma, especially if triggered by painkillers, Mefenamic acid 50mg + Paracetamol 125mg/5ml may cause breathing difficulty or wheezing. Hence, inform your doctor before taking it.
Pregnancy
Taking Mefenamic acid 50mg + Paracetamol 125mg/5ml during the last trimester of pregnancy may harm the unborn baby. Hence, consult your doctor before use.
Mefenamic acid 50mg + Paracetamol 125mg/5ml Interaction with Food Product
Mefenamic acid 50mg + Paracetamol 125mg/5ml should be taken after food to reduce stomach irritation and prevent discomfort. Taking it on an empty stomach may cause nausea or acidity. Alcohol should be avoided, as it can increase the risk of stomach irritation and bleeding.
Mefenamic acid 50mg + Paracetamol 125mg/5ml Interaction with Other Medicines
Avoid taking Mefenamic acid 50mg + Paracetamol 125mg/5ml with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Mefenamic acid 50mg + Paracetamol 125mg/5ml Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Mefenamic Acid: 2-(2,3-dimethylanilino)benzoic acid
Paracetamol: N-(4-hydroxyphenyl)acetamide
Intake routine/cycle
Daily dose
Take Mefenamic acid 50mg + Paracetamol 125mg/5ml exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take Mefenamic acid 50mg + Paracetamol 125mg/5ml more than the prescribed dose. Overdose, especially due to Paracetamol, can cause serious liver damage, along with symptoms like nausea, vomiting, severe stomach pain, dizziness, drowsiness, and loss of appetite. Excess Mefenamic Acid may also increase the risk of stomach ulcers, bleeding, and kidney problems. In case of any of these symptoms, seek immediate medical help.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take Mefenamic acid 50mg + Paracetamol 125mg/5ml exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Mefenamic acid 50mg + Paracetamol 125mg/5ml without your doctor’s approval, even if you feel better.
- If you forget to take Mefenamic acid 50mg + Paracetamol 125mg/5ml, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What are the uses of Mefenamic Acid tablets?
Mefenamic Acid tablets are used to treat menstrual pain (period pain), mild to moderate body pain, headache, toothache, muscle pain, joint pain, back pain, inflammation, and fever.
How many times a day should Mefenamic Acid be taken?
Mefenamic Acid is usually taken 2 to 3 times a day, as prescribed by the doctor. It should be taken after food to reduce stomach irritation, and the exact dose depends on the patient’s condition and age.
What is the mechanism of action of Mefenamic Acid?
Mefenamic Acid works by blocking cyclooxygenase (COX) enzymes, which reduces the production of prostaglandins chemicals in the body that cause pain, inflammation, and fever.
Can Mefenamic Acid be used during pregnancy?
Mefenamic Acid is not recommended during pregnancy, especially in the last 3 months, as it may harm the unborn baby. It should only be used if clearly prescribed by a doctor.
What is the drug class of Mefenamic Acid?
Mefenamic Acid belongs to the class of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
What are the uses for Paracetamol?
Paracetamol is used to reduce fever and relieve mild to moderate pain, such as headache, body ache, toothache, or sore throat.
What are the side effects of Paracetamol?
Paracetamol is usually safe if taken as directed. Sometimes it may cause nausea, stomach upset, or mild rash. Rarely, taking too much can harm the liver or cause serious allergic reactions. If you notice yellowing of the skin or eyes, swelling, or trouble breathing, stop the medicine and see a doctor immediately.
Reference
- PubChem. Mefenamic Acid [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Mefenamic Acid (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. Available from
- DrugBank. Mefenamic acid [Internet]. go.drugbank.com. 2022. Available from
- National Center for Biotechnology Information. Acetaminophen [Internet]. National Library of Medicine. PubChem; 2019. Available from
- DrugBank. Acetaminophen [Internet]. Drugbank Online. 2025. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.