Category- Allopathy
About Atracurium besylate 25 mg/2.5 ml Injection
Atracurium besylate 25 mg/2.5 ml Injection is a muscle relaxant used during surgical procedures and in ICU’s (intensive care settings). It helps relax the muscles, making it easier for doctors to perform surgery or insert a breathing tube. Atracurium works by blocking the transmission of nerve signals to the muscles, causing temporary muscle relaxation. Common side effects include flushing of the skin, low blood pressure, slow heart rate, and bronchospasm.
This medicine is administered by a trained healthcare professional in a hospital setting. Do not use this medicine if you are allergic to atracurium besylate or any of its ingredients.
Medicine Highlights
| Uses | 1. To provide muscle relaxation during surgical procedures 2. To facilitate endotracheal intubation (placement of a breathing tube) 3. To assist mechanical ventilation in intensive care units (ICUs) |
| Common Side Effects | 1. Flushing of the skin 2. Low blood pressure 3. Slow heart rate 4. Bronchospasm 5. Skin rash |
| Additional Information | 1. This medicine should only be administered by trained healthcare professionals. 2. Continuous monitoring of breathing and heart function is required during use |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Atracurium besylate Injection is given as an intravenous (IV) injection or infusion by a healthcare professional. |
Atracurium besylate 25 mg/2.5 ml Injection Uses
Atracurium besylate 25 mg/2.5 ml Injection is used to treat following infections:
- Muscle relaxation during surgery
- Facilitate endotracheal intubation
- Assist mechanical ventilation in ICU patients
- Maintain muscle relaxation during anesthesia
Atracurium besylate 25 mg/2.5 ml Injection side effects
More Common
- Flushing
- Low blood pressure
- Skin redness
- Slow heart rate
Less Common
- Bronchospasm
- Wheezing
- Allergic reactions
- Skin rash
- Histamine release-related reactions
How Atracurium besylate 25 mg/2.5 ml Injection works
This medicine contains atracurium besylate, which belongs to the class of neuromuscular blocking agents. It works by blocking the action of acetylcholine at the neuromuscular junction, preventing nerve impulses from reaching the muscles. This results in temporary muscle relaxation, which helps during surgery and assisted ventilation.
Safety Measures and Warning
Allergy/Hypersentivity
If you have ever had an allergic reaction to atracurium besylate or other muscle relaxants, inform your doctor before receiving this medicine.
Pregnancy
Atracurium besylate Injection should be used during pregnancy only if clearly needed and prescribed by a doctor.
Breastfeeding
Consult your doctor before using this medicine while breastfeeding.
Respiratory Disorders
If you have asthma or other breathing problems, communicate with your doctor about your past disease history because this medication should be monitored carefully, as atracurium may rarely cause bronchospasm.
Neuromuscular Disorders
This medication should be used with caution in patients with conditions such as myasthenia gravis, as increased sensitivity to the medicine may occur.
Atracurium besylate 25 mg/2.5 ml Injection Interaction with Food Product
Since this medicine is administered intravenously in a healthcare setting, food interactions are not expected.
Atracurium besylate 25 mg/2.5 ml Injection Interaction with Other Medicines
Avoid taking Atracurium besylate 25 mg/2.5 ml Injection with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Atracurium besylate 25 mg/2.5 ml Injection Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Atracurium besylate: benzenesulfonate;5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[1-[(3,4-dimethoxyphenyl) methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate
Intake routine/cycle
Daily dose
Take Atracurium besylate 25 mg/2.5 ml Injection exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Overdose of Atracurium Besilate Injection may cause prolonged muscle paralysis, severe breathing difficulty, and respiratory failure. Patients will require assisted ventilation and close medical monitoring until normal muscle function returns. Seek immediate medical attention if an overdose is suspected.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take Atracurium besylate 25 mg/2.5 ml Injection exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Atracurium besylate 25 mg/2.5 ml Injection without your doctor’s approval, even if you feel better.
- If you forget to take Atracurium besylate 25 mg/2.5 ml Injection, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What are the uses of Atracurium Besilate 25 mg/2.5 ml Injection?
Atracurium Besilate Injection is used to relax muscles during surgery, help with the insertion of a breathing tube, and assist patients who require mechanical ventilation in intensive care units.
How does Atracurium Besilate 25 mg/2.5 ml Injection work?
Atracurium works by blocking the transmission of nerve signals to the muscles, causing temporary muscle relaxation during medical procedures.
What are the common side effects of Atracurium Besilate 25 mg/2.5 ml Injection?
Common side effects include flushing of the skin, low blood pressure, slow heart rate, skin redness, and, rarely, breathing difficulties due to bronchospasm.
Can Atracurium Besilate 25 mg/2.5 ml Injection be used during pregnancy?
Atracurium Besilate Injection should only be used during pregnancy if prescribed by a doctor and when the potential benefits outweigh the risks.
Reference
- PubChem. Atracurium Besylate [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Jun 24]. Available from
- DrugBank. Atracurium besylate [Internet]. go.drugbank.com. 2024. Available from
- Tracrium (atracurium) dosing, indications, interactions, adverse effects, and more [Internet]. reference.medscape.com. Available from
- Pfizer.com. 2021. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.