Category- Allopathy
About Glimepiride 0.5 mg + Metformin (sr) 1000 mg
Glimepiride works by stimulating the pancreas to release more insulin, which helps lower blood sugar levels. Metformin (SR) helps reduce glucose production in the liver and improves insulin sensitivity. Together, they help maintain better blood sugar control and reduce the risk of diabetes-related complications.
It is usually taken with food as prescribed by the doctor. Common side effects of Glimepiride 0.5 mg + Metformin (SR) 1000 mg include low blood sugar, nausea, stomach pain, diarrhea, headache, and dizziness. Use with caution in people with kidney disease, liver disease, heart disease, pregnancy, or breastfeeding.
Medicine Highlights
| Uses | 1. To treat type 2 diabetes mellitus |
| Common Side Effects | 1. Low blood sugar (hypoglycemia) 2. Nausea 3. Stomach pain 4. Diarrhea 5. Vomiting 6. Headache 7. Dizziness 8. Weakness |
| Additional Information | 1. Avoid consuming alcohol and tobacco with this medicine 2. It is usually taken once daily, preferably in the evening, or as prescribed by your doctor. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | This medicine should be taken orally with a sip of water. |
Glimepiride 0.5 mg + Metformin (sr) 1000 mg Uses
Glimepiride 0.5 mg + Metformin (SR) 1000 mg is an oral medicine belonging to the class of Sulfonylurea + Biguanide anti-diabetic medicine and it is used to treat Type 2 diabetes mellitus.
Glimepiride 0.5 mg + Metformin (sr) 1000 mg side effects
More Common
- Low blood sugar (hypoglycemia)
- Nausea
- Stomach pain
- Diarrhea
- Vomiting
- Headache
- Dizziness
- Weakness
Less Common
- Skin rash
- Itching
- Loss of appetite
- Metallic taste in mouth
- Breathing difficulty
- Lactic acidosis
How Glimepiride 0.5 mg + Metformin (sr) 1000 mg works
Glimepiride 0.5 mg + Metformin (SR) 1000 mg tablet works by lowering blood sugar levels in different ways. Glimepiride increases insulin release from the pancreas, while Metformin reduces glucose production in the liver and improves insulin sensitivity. Together, they help control blood sugar effectively in people with type 2 diabetes.
Safety Measures and Warning
Allergy / Hypersensitivity
Do not take this medicine if you are allergic to Glimepiride, Metformin, sulfonylureas, or any of its ingredients, as it may cause rash, itching, swelling, or breathing difficulty.
Low Blood Sugar Problems
Do not skip meals while taking Glimepiride 0.5 mg + Metformin (SR) 1000 mg, as it may cause hypoglycemia leading to sweating, dizziness, confusion, or fainting.
Liver Disease Monitoring
Use with caution in liver disease, as side effects and low blood sugar risk may increase.
Kidney disease
People with kidney disease should use Glimepiride 0.5 mg + Metformin (SR) 1000 mg carefully and only under medical advice, as Metformin may accumulate and increase the risk of lactic acidosis.
Pregnancy
Pregnant women should take Glimepiride 0.5 mg + Metformin (SR) 1000 mg, take only if advised by a doctor, because blood sugar control during pregnancy needs careful monitoring.
Breastfeeding
Breastfeeding mothers should consult a doctor before taking Glimepiride 0.5 mg + Metformin (SR) 1000 mg, as it may pass into breast milk.
Glimepiride 0.5 mg + Metformin (sr) 1000 mg Interaction with Food Product
Take Glimepiride 0.5 mg + Metformin (SR) 1000 mg with food to reduce stomach upset and prevent low blood sugar. Avoid alcohol, as it may increase the risk of hypoglycemia and lactic acidosis. Maintain a healthy diabetic diet and regular exercise for better blood sugar control.
Glimepiride 0.5 mg + Metformin (sr) 1000 mg Interaction with Other Medicines
Avoid taking Glimepiride 0.5 mg + Metformin (sr) 1000 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Glimepiride 0.5 mg + Metformin (sr) 1000 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Glimepiride: 3-ethyl-4-methyl-\(N\)-[2-(4-{[(1\(r\),4\(r\))-4-methylcyclohexyl]carbamoyl}sulfamoyl)phenyl]ethyl]-2-oxo-2,5-dihydro-1\(H\)-pyrrole-1-carboxamide
Metformin: (N,N)-dimethylimidodicarbonimidic diamide
Intake routine/cycle
Daily dose
Take Glimepiride 0.5 mg + Metformin (sr) 1000 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take more than the prescribed dose. Taking too much may cause nausea, vomiting, diarrhea, stomach pain, or severe abdominal discomfort. In rare cases, allergic reactions may occur. Seek immediate medical attention if any severe symptoms develop.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take Glimepiride 0.5 mg + Metformin (sr) 1000 mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Glimepiride 0.5 mg + Metformin (sr) 1000 mg without your doctor’s approval, even if you feel better.
- If you forget to take Glimepiride 0.5 mg + Metformin (sr) 1000 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What is the mode of action of Glimepiride 0.5 mg + Metformin (SR) 1000 mg?
Glimepiride 0.5 mg + Metformin (SR) 1000 mg works by lowering blood sugar levels in two ways. Glimepiride increases the release of insulin from the pancreas, while Metformin reduces glucose production in the liver and improves the body’s response to insulin. Together, they help control blood sugar in people with type 2 diabetes.
What are the uses of Glimepiride 0.5 mg + Metformin (SR) 1000 mg tablets?
Glimepiride 0.5 mg + Metformin (SR) 1000 mg tablets are used to treat type 2 diabetes mellitus. They help control high blood sugar levels, improve insulin action, and reduce the risk of diabetes-related complications when combined with proper diet and exercise.
What are the side effects of Glimepiride 0.5 mg + Metformin (SR) 1000 mg tablets?
Common side effects of Glimepiride 0.5 mg + Metformin (SR) 1000 mg tablets include low blood sugar, nausea, stomach pain, diarrhea, vomiting, headache, dizziness, and weakness. Some people may also experience loss of appetite or a metallic taste in the mouth.
Reference
- PubChem. Metformin hydrochloride [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- GSRS [Internet]. Fda.gov. 2026 [cited 2026 May 8]. Available from
- Glimepiride [Internet]. go.drugbank.com. Available from
- AMARYL ® [Internet]. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.