Mefenamic acid 500 mg and Paracetamol 325 mg

Category- Allopathy

About Mefenamic acid 500 mg and Paracetamol 325 mg

This medicine consists of Mefenamic acid 500 mg and Paracetamol 325 mg is an analgesic medicine. It is used to reduce fever, relieve mild to moderate pain, and decrease inflammation. It works by lowering body temperature and blocking pain signals in the brain (Paracetamol), while also reducing the production of chemicals called prostaglandins that cause pain and swelling (Mefenamic Acid).  

This medicine should be given only as prescribed by a doctor, based on the individual’s age and weight. It should be taken after food to avoid stomach irritation, and overdose must be strictly avoided as it can cause serious liver damage, stomach ulcers, bleeding, or kidney problems. Common side effects of Mefenamic acid 500 mg and Paracetamol 325 mg are nausea, vomiting, stomach pain, diarrhea, dizziness, and loss of appetite, and medical help should be sought if any severe symptoms occur.

Medicine Highlights

Mefenamic acid 500 mg and Paracetamol 325 mg Uses

Mefenamic acid 500 mg and Paracetamol 325 mg tablet is used to treat symptoms of conditions like: 

1. Fever 
2. Headache 
3. Toothache 
4. Muscle pain 
5. Body pain due to infections 
6. Mild to moderate pain in children      

Mefenamic acid 500 mg and Paracetamol 325 mg side effects 

More Common

1. Nausea  
2. Vomiting  
3. Stomach pain  
4. Diarrhea  
5. Indigestion  
6. Dizziness  
7. Loss of appetite          

Less Common 

1. Severe stomach pain  
2. Liver problems (yellowing of skin or eyes)  
3. Allergic reaction (rash, itching, swelling)  
4. Breathing difficulty  
5. Stomach ulcer or bleeding (black stools, blood in vomit)  
6. Kidney problems (reduced urine output)      

How Mefenamic acid 500 mg and Paracetamol 325 mg works 

This medicine contains two active ingredients: Mefenamic Acid 500 mg and Paracetamol 325 mg. Mefenamic acid works by blocking the production of prostaglandins, which are chemicals responsible for causing pain, inflammation, and fever in the body. By reducing these chemicals, it helps relieve pain and discomfort. Paracetamol works by lowering fever and reducing pain. Together, these medicines provide effective and faster relief from fever and mild to moderate pain. 

Safety Measures and Warning 

Allergy/Hypersentivity

If you are allergic to Mefenamic acid 500 mg and Paracetamol 325 mg tablet, this can cause serious allergic reactions such as skin rash, itching, swelling of the face or throat, breathing difficulty, or severe reactions. Hence, inform your doctor if you have any history of allergy to painkillers before taking this medicine.

Stomach Ulcer or Bleeding

 If you have a history of stomach ulcers or bleeding, taking Mefenamic Acid can increase the risk of severe stomach pain, ulcers, or internal bleeding. Hence, inform your doctor before using Mefenamic acid 500 mg and Paracetamol 325 mg.

Kidney Disease

If you have kidney problems, Mefenamic acid 500 mg and Paracetamol 325 mg may worsen kidney function and reduce urine output. Hence, inform your doctor so the dose can be adjusted or avoided if necessary.

Liver Disease

If you have liver disease, Mefenamic acid 500 mg and Paracetamol 325 mg may affect liver function and cause complications. Hence, inform your doctor before taking it.

Heart Problems

 If you have heart disease or high blood pressure, Mefenamic acid 500 mg and Paracetamol 325 mg may increase the risk of heart-related complications. Hence, inform your doctor before use.

Asthma

 If you have asthma, especially if triggered by painkillers, Mefenamic acid 500 mg and Paracetamol 325 mg may cause breathing difficulty or wheezing. Hence, inform your doctor before taking it.

Pregnancy

Taking Mefenamic acid 500 mg and Paracetamol 325 mg during the last trimester of pregnancy may harm the unborn baby. Hence, consult your doctor before use.

Mefenamic acid 500 mg and Paracetamol 325 mg Interaction with Food Product 

Mefenamic acid 500 mg and Paracetamol 325 mg tablet should be taken after food to reduce stomach irritation and prevent discomfort. Taking it on an empty stomach may cause nausea or acidity. Alcohol should be avoided, as it can increase the risk of stomach irritation and bleeding.  

Mefenamic acid 500 mg and Paracetamol 325 mg Interaction with Other Medicines  

Avoid taking Mefenamic acid 500 mg and Paracetamol 325 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Mefenamic acid 500 mg and Paracetamol 325 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Mefenamic Acid: 2-(2,3-dimethylanilino) benzoic acid 

Paracetamol: N-(4-hydroxyphenyl) acetamide

Intake routine/cycle

Daily dose

Take Mefenamic acid 500 mg and Paracetamol 325 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Mefenamic acid 500 mg and Paracetamol 325 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Mefenamic acid 500 mg and Paracetamol 325 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Mefenamic acid 500 mg and Paracetamol 325 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

FAQ’s

What are the uses of Mefenamic acid 500 mg and Paracetamol 325 mg tablet? 

Mefenamic acid 500 mg and Paracetamol 325 mg tablet is used to relieve pain and reduce fever. It helps manage headaches, toothaches, menstrual pain, muscle pain, joint pain, and other mild to moderate painful conditions.

How does Mefenamic acid 500 mg and Paracetamol 325 mg tablet work? 

Mefenamic Acid reduces pain and inflammation, while Paracetamol helps relieve pain and lowers body temperature. 

What are the common side effects of Mefenamic acid 500 mg and Paracetamol 325 mg tablet?

Common side effects of Mefenamic acid 500 mg and Paracetamol 325 mg tablet may include nausea, vomiting, stomach discomfort, heartburn, dizziness, and indigestion.

What precautions should be taken while using Mefenamic acid 500 mg and Paracetamol 325 mg tablet? 

Take this medicine after food to reduce stomach irritation. Do not exceed the recommended dose, and inform your doctor if you have liver, kidney, or stomach problems. 

Reference  

1. PubChem. Mefenamic Acid [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
2. Mefenamic Acid (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. Available from 
3. DrugBank. Mefenamic acid [Internet]. go.drugbank.com. 2022. Available from 
4. National Center for Biotechnology Information. Acetaminophen [Internet]. National Library of Medicine. PubChem; 2019. Available from 
5. DrugBank. Acetaminophen [Internet]. Drugbank Online. 2025. Available from        

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.