Aceclofenac, Paracetamol and Chymotrypsin

Category- Allopathy

About Aceclofenac, Paracetamol and Chymotrypsin

Aceclofenac, Paracetamol and Chymotrypsin Tablets is used to relieve pain, reduce inflammation, and decrease swelling associated with musculoskeletal conditions, injuries, and after surgery. Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by blocking prostaglandin production. Paracetamol acts as an analgesic and antipyretic to relieve pain and fever, while Trypsin-Chymotrypsin is a proteolytic enzyme that helps reduce swelling and promotes tissue healing. 

This medicine should be taken exactly as prescribed by your doctor. It is usually taken after food to reduce stomach irritation. Do not exceed the recommended dose, as prolonged or excessive use may increase the risk of stomach ulcers, liver damage, kidney problems, or bleeding. People with liver disease, kidney disease, stomach ulcers, or heart disease should consult their doctor before using this medicine.     

Medicine Highlights

Aceclofenac, Paracetamol and Chymotrypsin Uses

Aceclofenac, Paracetamol, and Chymotrypsin is an oral medicine. It is used for following indications: 

1. Osteoarthritis  
2. Rheumatoid arthritis  
3. Ankylosing spondylitis  
4. Muscle pain  
5. Back pain  
6. Sports injuries  
7. Dental pain  
8. Pain and swelling after surgery or trauma                       

Aceclofenac, Paracetamol and Chymotrypsin side effects 

More Common

1. Nausea  
2. Vomiting  
3. Stomach pain  
4. Indigestion  
5. Diarrhea                

Less Common 

1. Stomach ulcer or bleeding  
2. Black or bloody stools  
3. Yellowing of the skin or eyes  
4. Allergic reactions  
5. Severe skin rash  
6. Kidney problems            

How Aceclofenac, Paracetamol and Chymotrypsin work 

This medicine contains aceclofenac, paracetamol, and chymotrypsin. Aceclofenac works by blocking cyclooxygenase (COX) enzymes, reducing prostaglandin production responsible for pain and inflammation. Paracetamol reduces pain and fever by inhibiting prostaglandin synthesis mainly in the central nervous system. Trypsin-Chymotrypsin is a proteolytic enzyme that breaks down inflammatory proteins, helping reduce swelling, improve tissue repair, and speed up healing. 

Safety Measures and Warning 

Allergy/Hypersentivity

Do not take this medicine, if you are allergic to paracetamol, aceclofenac or any of its ingredients. Seek immediate medical attention if you develop a rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing.

Stomach Ulcers

Inform your doctor if you have a history of stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease.

Liver Disease

If you have liver disease, paracetamol and aceclofenac may increase the risk of liver damage. Always communicate with your doctor about your past disease history.

Kidney Disease

Patients with kidney disease should use this medicine only under medical supervision. This medicine can increase the side effects.

Heart Disease

Patients with heart disease or high blood pressure should avoid these medicines, as NSAIDs may increase the risk of cardiovascular events. Always communicate with your doctor.

Pregnancy

Avoid using this medicine during pregnancy, especially during the third trimester, unless prescribed by your doctor.

Breastfeeding

Consult your doctor before using this medicine while breastfeeding.

Aceclofenac, Paracetamol and Chymotrypsin Interaction with Food Product 

This medicine should preferably be taken after food to reduce stomach irritation. Avoid consuming alcohol while taking this medicine, as it may increase the risk of liver damage and stomach bleeding.

Aceclofenac, Paracetamol and Chymotrypsin Interaction with Other Medicines  

Avoid taking Aceclofenac, Paracetamol and Chymotrypsin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Aceclofenac, Paracetamol and Chymotrypsin Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Paracetamol: N-(4-hydroxyphenyl) acetamide 

Aceclofenac: 2-[2-[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl]oxyacetic acid 

Chymotrypsin: α‑Chymotrypsin 

Intake routine/cycle

Daily dose

Take Aceclofenac, Paracetamol and Chymotrypsin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Overdose may cause severe stomach pain, nausea, vomiting, gastrointestinal bleeding, liver damage, kidney injury, dizziness, or drowsiness. Seek immediate medical attention if an overdose is suspected.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Aceclofenac, Paracetamol and Chymotrypsin exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Aceclofenac, Paracetamol and Chymotrypsin without your doctor’s approval, even if you feel better. 
3. If you forget to take Aceclofenac, Paracetamol and Chymotrypsin, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

FAQ’s

Can paracetamol make you sleepy? 

Yes, paracetamol is made up of acetaminophen, which is responsible for causing drowsiness, a common side effect.

How many paracetamols can we take in a day? 

An adult can take up to 2 tablets of 500 mg with a 6-hour gap, up to four times a day. Children aged 10-15 years can take 1 tablet four times a day, with a gap of 4-6 hours between doses.

What are the uses of chymotrypsin tablets? 

Chymotrypsin tablets are mainly used to reduce pain, swelling, and inflammation after surgery, injury, or trauma, and they help wounds heal faster by improving blood circulation.

What are the side effects of chymotrypsin? 

Chymotrypsin is generally well tolerated, but they can sometimes cause mild stomach upset, nausea, diarrhea, headache, dizziness, or skin rash, and rarely may trigger allergic reactions like itching, swelling, or breathing difficulty.

What are the side effects of Aceclofenac? 

Common side effects include stomach pain, acidity, nausea, dizziness, headache, and rash. Rarely, it may cause liver or kidney problems, high blood pressure, or gastric bleeding with long-term use. 

What is the usual dose of Aceclofenac per day? 

The typical adult dose is 100 mg twice a day (morning and evening), preferably after meals. Do not exceed 200 mg per day unless advised by your doctor.

Reference  

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7. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for Chymotrypsin; [cited 2026 Mar. 12]. Available from. 
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10. ScienceDirect. Chymotrypsin [Internet]. Elsevier; [cited 2026 Mar 12]. Available from.               

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.