Category- Allopathy
About Sacubitril 49 mg + Valsartan 51 mg
Sacubitril 49 mg + Valsartan 51 mg tablet is used to treat high blood pressure and chest pain due to poor blood flow to the heart. It works by relaxing blood vessels and improving circulation, which eases the heart’s workload. Common side effects include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes. People with serious liver problems, very low blood pressure, or heart issues, or women who are pregnant or breastfeeding, should inform their doctor before using it. Drinking grapefruit juice with this medication makes it stronger and increases side effects, so it’s best skipped. Always store this medicine in a cool, dry place away from sunlight, and keep it in its original packaging. Taking more than 100 mg of this medicine daily can cause overdosing effects like severe hypotension, dizziness, fainting, and potentially life-threatening cardiovascular collapse.
Medicine Highlights
| Uses | 1. To treat high blood pressure 2. To prevent heart attacks. |
| Common Side Effects | 1. Headache 2. Dizziness 3. Constipation 4. Skin rash 5. Decreased blood pressure 6. Nausea |
| Additional Information | 1. Take medicine every day at the same time to maintain the drug well in the blood. 2. Do not stop the medicine usage suddenly |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medicine orally with a sip of water |
Sacubitril 49 mg + Valsartan 51 mg Uses
Sacubitril 49 mg + Valsartan 51 mg tablet is used to treat heart failure in adults and children and it is also used off label for is also used to improve conditions of chemotherapy and cancer related heart problems, irregular heartbeat prevention, kidney protection in diabetes and early-stage heart failure.
Sacubitril 49 mg + Valsartan 51 mg side effects
More Common
- Headache
- Dizziness
- Constipation
- Skin rash
- Decreased blood pressure
- Nausea
Less Common
- Lightheadedness
- Palpitations
- Oedema (accumulation of water in the tissues)
How Sacubitril 49 mg + Valsartan 51 mg works
Sacubitril 49 mg + Valsartan 51 mg tablet contains two components: Sacubitril helps in relaxing blood vessels and reducing fluid buildup, thereby easing the load on the heart, whereas Valsartan blocks a hormone that causes blood vessels to narrow and relieves blood pressure. Together, they lower blood pressure, reduce fluid overload, and make the heart pump more effectively.
Safety Measures and Warning
Pregnancy
Pregnant women are not recommended to take Sacubitril 49 mg + Valsartan 51 mg tablet, as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.
Breastfeeding
Sacubitril 49 mg + Valsartan 51 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.
Kidney and Liver Problems
Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using it.
Sacubitril 49 mg + Valsartan 51 mg Interaction with Food Product
Sacubitril 49 mg + Valsartan 51 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Sacubitril 24 mg + Valsartan 26 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.
Sacubitril 49 mg + Valsartan 51 mg Interaction with Other Medicines
Avoid taking Sacubitril 49 mg + Valsartan 51 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Sacubitril 49 mg + Valsartan 51 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Sacubitril- 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Valsartan-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Intake routine/cycle
Daily dose
Take Sacubitril 49 mg + Valsartan 51 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take more than 600 mg of Sacubitril + Valsartan per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take Sacubitril 49 mg + Valsartan 51 mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Sacubitril 49 mg + Valsartan 51 mg without your doctor’s approval, even if you feel better.
- If you forget to take Sacubitril 49 mg + Valsartan 51 mg, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What is the mechanism of action of Sacubitril 49 mg + Valsartan 51 mg?
Sacubitril 49 mg + Valsartan 51 mg preserves natural chemicals that relax blood vessels and reduce fluid, easing heart strain. Valsartan blocks a tightening hormone, keeping vessels open, together they lower pressure and help the heart pump better.
What are the uses of Sacubitril 49 mg + Valsartan 51 mg?
Sacubitril 49 mg + Valsartan 51 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.
What are the side effects of the Sacubitril 49 mg + Valsartan 51 mg tablets?
Common side effects of Sacubitril 49 mg + Valsartan 51 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.
Reference
- PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 60846, Valsartan; [cited 2026 May 19]. Available from.
- PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 9811834, Sacubitril; [cited 2026 May 19]. Available from.
- WebMD [Internet]. Entresto (sacubitril/valsartan): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. [cited 2026 May 19]. Available from.
- Drugs.com [Internet]. Sacubitril and valsartan: uses, side effects, interactions, pictures, warnings & dosing. [cited 2026 May 19]. Available from.
Authors
Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.