Hyoscine 10mg + Mefenamic acid 250mg

Category- Allopathy

About Hyoscine 10mg + Mefenamic acid 250mg

Hyoscine 10 mg + Mefenamic Acid 250 mg tablet is used to relieve abdominal cramps, menstrual pain (dysmenorrhea), stomach pain, intestinal cramps, and pain associated with muscle spasms. This medicine consists of active ingredients such as hyoscine and mefenamic acid, where hyoscine works by relaxing the smooth muscles of the stomach, intestines, and urinary tract, helping to reduce spasms and cramps, while mefenamic acid works by blocking the production of certain chemicals (prostaglandins) that cause pain, inflammation, and discomfort. 

The dose should be taken exactly as prescribed by a doctor. To get the maximum benefit from this medicine, take it as directed by your healthcare provider. 

Common side effects include dry mouth, nausea, dizziness, headache, stomach discomfort, constipation, and blurred vision. In rare cases, it may cause severe allergic reactions, stomach ulcers, gastrointestinal bleeding, difficulty urinating, or rapid heartbeat that requires immediate medical attention. 

Taking more than the recommended dose may cause severe nausea, vomiting, stomach pain, dizziness, drowsiness, blurred vision, rapid heartbeat, seizures, stomach bleeding, or kidney problems. Seek immediate medical attention if overdose symptoms occur.     

Medicine Highlights

Hyoscine 10mg + Mefenamic acid 250mg Uses

Hyoscine 10 mg + Mefenamic Acid 250 mg tablet is used to treat the following conditions: 

1. Menstrual cramps (dysmenorrhea) 
2. Abdominal cramps 
3. Intestinal spasms 
4. Stomach pain caused by muscle spasms 
5. Pain associated with gastrointestinal disorders                   

Hyoscine 10mg + Mefenamic acid 250mg side effects 

More Common

1. Dry mouth 
2. Nausea 
3. Dizziness 
4. Headache 
5. Stomach discomfort 
6. Constipation 
7. Blurred vision             

Less Common 

1. Stomach ulcer 
2. Gastrointestinal bleeding 
3. Difficulty urinating 
4. Rapid heartbeat 
5. Severe allergic reactions 
6. Skin rash 
7. Swelling of face or throat          

How Hyoscine 10mg + Mefenamic acid 250mg works 

This medicine consists of active ingredients such as hyoscine and mefenamic acid that work together to relieve cramps and pain. Hyoscine is an antispasmodic medicine that relaxes the smooth muscles of the stomach, intestines, and urinary tract, reducing spasms and cramping. Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by blocking the production of prostaglandins. Together, they provide effective relief from painful spasmodic conditions.

Safety Measures and Warning 

Allergy/Hypersentivity

If you are allergic to hyoscine, mefenamic acid, other NSAIDs, or any of the ingredients, avoid using this medicine. Serious allergic reactions such as rash, itching, swelling, or breathing difficulty may occur.

Stomach Disorders

 If you have a history of stomach ulcers, gastrointestinal bleeding, or inflammatory bowel disease, mefenamic acid may worsen these conditions. Always communicate with your doctor about your past disease history for your safety. 

Kidney or Liver Disease

Patients with kidney or liver problems may require dose adjustments. Consult your doctor before taking this medicine.

Glaucoma and Urinary Problems

Use cautiously in patients with glaucoma, enlarged prostate, or urinary retention, as hyoscine may worsen these conditions.

Hyoscine 10mg + Mefenamic acid 250mg Interaction with Food Product 

Hyoscine 10 mg + Mefenamic Acid 250 mg tablet can be taken after food to reduce stomach irritation. Avoid excessive alcohol consumption as it may increase the risk of stomach irritation, ulcers, bleeding, dizziness, and drowsiness. 

Hyoscine 10mg + Mefenamic acid 250mg Interaction with Other Medicines  

Avoid taking Hyoscine 10mg + Mefenamic acid 250mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Hyoscine 10mg + Mefenamic acid 250mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Hyoscine: 1-bromobutane;[(1S,2S,4R,5R)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0^2,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate 

Mefenamic Acid: 2-(2,3-dimethylanilino) benzoic acid 

Intake routine/cycle

Daily dose

Take Hyoscine 10mg + Mefenamic acid 250mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than the prescribed dose of Hyoscine 10 mg + Mefenamic Acid 250 mg. Overdose may cause severe nausea, vomiting, stomach pain, dizziness, drowsiness, blurred vision, rapid heartbeat, seizures, stomach bleeding, kidney problems, or difficulty urinating. Seek immediate medical attention if overdose symptoms occur.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Hyoscine 10mg + Mefenamic acid 250mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Hyoscine 10mg + Mefenamic acid 250mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Hyoscine 10mg + Mefenamic acid 250mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

FAQ’s

What are the uses of Hyoscine Butyl bromide 10 mg + Mefenamic Acid 250 mg tablet?

Hyoscine Butyl bromide 10 mg + Mefenamic Acid 250 mg tablet is used to relieve abdominal cramps, menstrual pain, intestinal spasms, stomach pain, and other painful conditions caused by muscle spasms and inflammation. 

How does Hyoscine Butyl bromide 10 mg + Mefenamic Acid 250 mg work? 

Hyoscine Butyl bromide relaxes the muscles of the stomach, intestines, and urinary tract, helping to reduce cramps and spasms. Mefenamic Acid reduces pain and inflammation by blocking the production of certain chemicals called prostaglandins. 

What are the common side effects of Hyoscine Butyl bromide 10 mg + Mefenamic Acid 250 mg? 

Common side effects include dry mouth, nausea, dizziness, headache, stomach discomfort, constipation, and blurred vision. These side effects are usually mild and temporary. 

Who should avoid taking Hyoscine Butyl bromide 10 mg + Mefenamic Acid 250 mg? 

This medicine should be avoided by people who are allergic to hyoscine, mefenamic acid, or other NSAIDs. It should also be avoided in patients with active stomach ulcers, gastrointestinal bleeding, glaucoma, severe liver disease, severe kidney disease, bowel obstruction, or urinary retention.  

Reference  

1. PubChem. hyoscine-N-butyl bromide [Internet]. Nih.gov. PubChem; 2025. Available from 
2. PubChem. Mefenamic Acid [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
3. Mefenamic Acid (Oral Route) Description and Brand Names – Mayo Clinic [Internet].  Available from 
4. DrugBank. Mefenamic acid [Internet]. go.drugbank.com. 2022. Available from 
5. Tytgat GN. Hyoscine butyl bromide: a review of its use in the treatment of abdominal cramping and pain. Drugs [Internet]. 2007;67(9):1343–57. Available from          

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.