Category- Allopathy
Medicine Highlights
| Uses | 1. To treat muscle pain and spasms 2. To treat back pain 3. To treat neck pain 4. To treat joint pain 5. To treat pain due to spondylitis or slipped disc 6. To treat shoulder pain or frozen shoulder |
| Common Side Effects | 1. Stomach pain or acidity 2. Nausea (feeling like vomiting) 3. Vomiting 4. Diarrhea 5. Indigestion / gas / bloating 6. Dizziness 7. Sleepiness or drowsiness 8. Weakness or tiredness |
| Additional Information | To keep you safe and healthy, use this medicine only with your doctor’s guidance. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medication orally with a sip of water. |
Aceclofenac + Paracetamol + Thiocolchicoside Uses
This is a combination medicine and is used to treat in the following conditions:
- Muscle pain and spams
- Back pain
- Neck pain
- Joint pain
- Pain due to spondylitis or slipped disc
- Shoulder pain or frozen shoulder
Aceclofenac + Paracetamol + Thiocolchicoside side effects
More Common
- Stomach pain or acidity
- Nausea (feeling like vomiting)
- Vomiting
- Diarrhea
- Indigestion / gas / bloating
- Dizziness
- Sleepiness or drowsiness
- Weakness or tiredness
Less Common
- Severe stomach ulcer or bleeding (black stools, blood in vomit, severe stomach pain)
- Liver problems (yellow eyes/skin, dark urine, unusual tiredness)
- Kidney problems (less urine, swelling in legs/feet)
- Severe allergy (rash, itching, swelling of face/lips, trouble breathing)
- Fits / seizures
How Aceclofenac + Paracetamol + Thiocolchicoside works
This medicine works in three ways to give relief from pain and muscle tightness. Aceclofenac reduces the chemicals in the body that cause pain, swelling, and inflammation. Paracetamol helps reduce pain and can also bring down fever. Thiocolchicoside acts as a muscle relaxant and helps loosen tight, stiff, or painful muscles. Together, this combination helps reduce pain, inflammation, and muscle spasm, making movement easier and more comfortable.
Safety Measures and Warning
Allergy or Hypersensitivity
People allergic to this medicine, or any ingredients of this medication are not recommended to take this medicine as it can cause serious allergic reactions like rash, swelling, or trouble breathing. Always ask your doctor first.
Liver problems
If you have liver disease, consult your doctor before taking this medicine because it can increase the risk of liver damage.
Kidney problems
If you have kidney disease, consult your doctor before taking this medicine because it can worsen kidney function.
Heart problems
If you have heart disease or high blood pressure, consult your doctor before taking this medicine because it can cause fluid retention and may worsen heart problems.
Asthma
If you have asthma, especially after taking painkillers, consult your doctor before taking this medicine because it can trigger breathing problems.
Pregnancy
If you are pregnant or planning pregnancy, take this medicine only if your doctor advises it. It may harm the baby, especially in later pregnancy.
Breastfeeding women
If you are breastfeeding, ask your doctor before taking it. Some amount of the medicine may pass into breast milk and affect the baby.
Aceclofenac + Paracetamol + Thiocolchicoside Interaction with Food Product
It is best to avoid or limit alcohol while taking this medicine because it can increase drowsiness and may raise the risk of stomach irritation or liver problems. Very heavy or oily meals may also cause more stomach discomfort in some people.
Aceclofenac + Paracetamol + Thiocolchicoside Interaction with Other Medicines
Avoid taking Aceclofenac + Paracetamol + Thiocolchicoside with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Aceclofenac + Paracetamol + Thiocolchicoside Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Aceclofenac: 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acid
Paracetamol – N-acetyl-para-aminophenol (APAP), acetaminophen
Thiocolchicoside: N-[(7S)-1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Intake routine/cycle
Daily dose
Take Aceclofenac + Paracetamol + Thiocolchicoside exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children.
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Aceclofenac + Paracetamol + Thiocolchicoside Summary
Aceclofenac 100 mg + Paracetamol 325 mg + Thiocolchicoside 4 mg is a combination medicine used to relieve pain, swelling, and muscle stiffness. It is commonly used for back pain, neck pain, joint pain, muscle pain, sprains, strains, and painful muscle spasms. Aceclofenac helps reduce pain and inflammation, Paracetamol helps reduce pain and fever, and Thiocolchicoside helps relax tight muscles. Common side effects include acidity, stomach pain, nausea, diarrhea, dizziness, drowsiness, and weakness.
Rare but serious side effects may include stomach bleeding, liver problems, kidney problems, allergy, or seizures. This medicine should be used carefully in people with ulcers, liver/kidney disease, asthma, or seizure history. It works well for pain with muscle tightness and helps improve comfort and movement.
FAQ’s
Can paracetamol make you sleepy?
Yes, paracetamol is made up of acetaminophen, which is responsible for causing drowsiness, a common side effect.
Can paracetamol cure colds?
No, paracetamol is used to treat pain and fever.
How many paracetamols can we take in a day?
An adult can take up to 2 tablets of 500 mg with a 6-hour gap, up to four times a day. Children aged 10-15 years can take 1 tablet four times a day, with a gap of 4-6 hours between doses.
Can paracetamol delay periods?
No, there is no side effect of paracetamol that affects the pattern of periods. A delay in periods can occur due to many reasons.
How much paracetamol can I take when pregnant?
You can take 500 mg of paracetamol up to four times a day. Paracetamol does not cross the placenta and is not known to cause harm to your fetus.
Can paracetamol be used for headaches?
Yes, paracetamol is used to treat headaches.
What are the side effects of Aceclofenac?
Common side effects include stomach pain, acidity, nausea, dizziness, headache, and rash. Rarely, it may cause liver or kidney problems, high blood pressure, or gastric bleeding with long-term use.
What is the usual dose of Aceclofenac per day?
The typical adult dose is 100 mg twice a day (morning and evening), preferably after meals. Do not exceed 200 mg per day unless advised by your doctor.
How does Aceclofenac work (mode of action)?
Aceclofenac works by blocking COX enzymes, especially COX-2, which produce prostaglandins chemicals that cause pain and inflammation. By lowering prostaglandin levels, it helps reduce pain, swelling, and stiffness.
What is thiocolchicoside duration of action?
The duration of thiocolchicoside is about 8 to 12 hours. Its onset of action is 1 to 2 hours if it is taken orally and 30 minutes to 1 hour if it is taken in injectable form also its half-life is 1.5 hours.
Reference
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- PubChem. Aceclofenac [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Aceclofenac [Internet]. go.drugbank.com. Available from
- European Medicines Agency recommends restricting use of thiocolchicoside by mouth or injection | European Medicines Agency (EMA) [Internet]. European Medicines Agency (EMA). 2013 [cited 2025 Jul 15]. Available from
- Kamath A. Thiocolchicoside: A review. DHR International Journal of Medical Sciences (DHR-IJMS [Internet]. [cited 2025 Jul 15];4(2):2013. Available from
- Thiocolchicoside: Uses, Interactions, Mechanism of Action | DrugBank Online [Internet]. Drugbank.com. DrugBank; 2020. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.