Tolperisone 150 mg + Etoricoxib 60 mg

Category- Allopathy

Medicine Highlights

Tolperisone 150 mg + Etoricoxib 60 mg Uses

Tolperisone 150 mg + Etoricoxib 60 mg is an oral combination medicine belonging to the category of muscle relaxant + pain-relieving anti-inflammatory medicine (NSAID), and is used to treat following conditions:  

1. Muscle Spasm (sudden tightening of muscles)  
2. Muscle Pain (pain in muscles)  
3. Back Pain (pain in the lower or upper back)  
4. Neck Pain (pain with stiffness in the neck)  
5. Muscle Stiffness (tight or hard-to-move muscles)  
6. Sprain or Strain Pain (pain after twisting or pulling a muscle/ligament)      

Tolperisone 150 mg + Etoricoxib 60 mg side effects 

More Common  

1. Stomach pain or stomach upset  
2. Nausea (feeling like vomiting)  
3. Acidity / heartburn  
4. Indigestion  
5. Gas / bloating  
6. Diarrhea (loose motions)  
7. Constipation  
8. Dizziness  
9. Headache  
10. Sleepiness / drowsiness  
11. Weakness or tiredness  
12. Dry mouth  
13. Swelling in feet or ankles (fluid retention)
14. Palpitations (feeling of fast heartbeat)  
15. Mild increase in blood pressure        

Less Common 

1. Severe allergic reaction (rash, itching, swelling, breathing trouble)  
2. Severe stomach pain  
3. Stomach ulcer or stomach bleeding  
4. Black stools or vomiting blood  
5. Chest pain  
6. Shortness of breath  
7. Sudden rise in blood pressure  
8. Irregular heartbeat  
9. Kidney problems (less urine, swelling, sudden fluid retention)  
10. Liver problems (yellow eyes/skin, dark urine)  
11. Low blood pressure (sometimes from tolperisone)  
12. Severe weakness  
13. Serious skin reaction      

How Tolperisone + Etoricoxib works 

This medicine works in two ways. Tolperisone helps relax tight or stiff muscles and reduces muscle spasm. Etoricoxib helps reduce pain and swelling. Together, they help relieve muscle tightness, reduce pain, and make movement easier and more comfortable. 

Safety Measures and Warning 

Allergy or Hypersensitivity

 If you are allergic to tolperisone, etoricoxib, or any ingredient in the medicine, you should avoid it because it can cause serious allergic reactions like rash, itching, swelling, or breathing problems. 

Stomach Ulcers or Bleeding

If you have a stomach ulcer, a history of stomach bleeding, or bleeding in the stomach or bowels, tell your doctor before taking this medicine. The etoricoxib can irritate the stomach and may increase the risk of ulcer or bleeding. 

Severe Liver Disease

If you have serious liver problems, tell your doctor before taking this medicine. The medicine is processed in the liver, and if the liver is not working properly, the medicine can build up in the body and increase the risk of side effects. 

Severe Kidney Disease

If you have serious kidney problems, tell your doctor before taking this medicine. This medicine can affect kidney function, and if the kidneys are already weak, the risk of side effects and medicine build-up becomes higher. It should be avoided in severe kidney disease. 

Heart Disease or Heart Failure

If you have heart failure, chest pain, previous heart attack, bypass surgery, stroke, or other serious heart problems, inform your doctor before taking this medicine. The etoricoxib part may increase the risk of heart-related side effects, especially in people with existing heart disease. 

High Blood Pressure (Uncontrolled Hypertension)

If your blood pressure is not well controlled, tell your doctor before taking this medicine. Etoricoxib can sometimes increase blood pressure, which may become dangerous in some people. 

Myasthenia Gravis

If you have myasthenia gravis (a condition that causes muscle weakness), you should avoid tolperisone unless your doctor specifically advises it, because it may worsen muscle weakness.  

Pregnancy

If you are pregnant or planning pregnancy, tell your doctor before taking this medicine. It is usually avoided during pregnancy, especially because the etoricoxib part may not be safe. 

Breastfeeding

If you are breastfeeding, inform your doctor before taking this medicine. It is usually not recommended unless the doctor feels it is necessary. 

Children below 16 years

This medicine is usually not recommended for children under 16 years of age unless a doctor specifically prescribes it.

Tolperisone + Etoricoxib Interaction with Food Product 

There are no major food restrictions, but alcohol should be avoided as it may increase dizziness or lower blood pressure. Always follow your doctor’s advice while using this medicine.

Tolperisone + Etoricoxib Interaction with Other Medicines  

Avoid taking Tolperisone + Etoricoxib with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Tolperisone + Etoricoxib Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Tolperisone: 2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one 

Etoricoxib: 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-2,3′-bipyridine 

Intake routine/cycle

Daily dose

Take Tolperisone + Etoricoxib exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended more than the prescribed dose of this combination, as it may cause severe adverse effects like nausea, vomiting, diarrhea, dizziness, and in rare cases, seizures.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

Directions for use 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

Tolperisone + Etoricoxib Summary 

Tolperisone 150 mg + Etoricoxib 60 mg is a combination medicine used to treat muscle pain, muscle spasm (sudden tightening of muscles), muscle stiffness, back pain, neck pain, sprain or strain pain, and other body pain with swelling. Tolperisone helps relax tight muscles, while Etoricoxib helps reduce pain and inflammation, so together they make movement easier and more comfortable. Common side effects may include stomach upset, nausea, acidity, indigestion, dizziness, headache, sleepiness, weakness, dry mouth, diarrhea, and sometimes swelling in the feet. Rare but serious side effects can include stomach ulcer or bleeding, severe allergy, chest pain, breathing trouble, high blood pressure, and liver or kidney problems.  

This medicine should be avoided or used only with a doctor’s advice in people with allergy to this medicine or painkillers, stomach ulcer or bleeding, severe liver or kidney disease, heart problems, uncontrolled high blood pressure, and during pregnancy or breastfeeding. It belongs to the class of medicines called a muscle relaxant plus pain-relieving anti-inflammatory medicine (NSAID). 

FAQ’s

How many times should one take Etoricoxib in a day?  

If the medicine is prescribed with a higher dose, then it should be taken once a day and if the medicine is prescribed with a lower dose, then it should be taken twice a day.  However, one should always use it as prescribed by your doctor. 

What is the etoricoxib drug class?  

Etoricoxib, is an NSAID used to relieve pain in certain conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout. 

Can I use etoricoxib for tooth pain?  

Yes, as etoricoxib is a pain killer it is used for toothache and during dental surgeries.

Can etoricoxib cause hepatotoxicity?  

Yes, as etoricoxib is an NSAID it can cause hepatotoxicity but less when compared to other NSAID’s.

What are the uses of etoricoxib tablets?

 Etoricoxib 60 mg is an oral medicine belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) it is used for the following indications: To reduce Pain and Swelling in diseases like, Osteoarthritis, Rheumatoid arthritis, Ankylosing spondylitis and Gout.  

What are the uses of Tolperisone tablet? 

Tolperisone tablet is used to treat muscle spasm and muscle stiffness. It helps relieve tight muscles, muscle pain, back pain, neck pain, and painful muscle conditions, and makes movement easier. It is mainly used in acute painful musculoskeletal conditions. 

What are the side effects of Tolperisone tablet? 

Common side effects of tolperisone may include sleepiness, dizziness, tiredness, dry mouth, nausea, vomiting, stomach pain, and muscle weakness. These are usually mild, but if they become severe or do not go away, you should tell your doctor. Rarely, it may also cause low blood pressure or allergy in some people. 

Reference 

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Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.