Guaifenesin 100 mg + Terbutaline 2.5 mg + Bromhexine 8 mg /10 ml

Category- Allopathy

Medicine Highlights

Guaifenesin + Terbutaline + Bromhexine Uses  

Guaifenesin + Terbutaline + Bromhexine is an oral combination medicine that acts as an expectorant, bronchodilator, and mucolytic agent. This medicine is used to prevent and treat conditions like: 

1. Cough associated with respiratory infections 
2. Bronchitis 
3. Asthma 
4. Emphysema  
5. Chronic obstructive pulmonary disease (COPD) 

Directions for use

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

Guaifenesin + Terbutaline + Bromhexine side effects 

More Common  

1. Nausea 
2. Vomiting 
3. Headache 
4. Dizziness 
5. Tremors 
6. Nervousness 
7. Stomach upset 
8. Sweating  

Less Common

1. Palpitations (fast heartbeat) 
2. Chest pain 
3. Allergic reactions (rash, itching, swelling) 
4. Difficulty in breathing 
5. Sleep disturbances 
6. Muscle cramps   

How Guaifenesin + Terbutaline + Bromhexine works 

Guaifenesin + Terbutaline + Bromhexine works by clearing mucus and easing breathing. Guaifenesin helps thin and loosen mucus, making it easier to cough out. Terbutaline relaxes the muscles in the airways, allowing more air to pass through and making breathing easier. Ambroxol breaks down thick mucus and helps clear it from the lungs. Together, they help relieve cough, remove mucus, and improve breathing in respiratory conditions. 

Safety Measures and Warning 

Allergy/Hypersensitivity

Do not take this medicine if you are allergic to Guaifenesin, Terbutaline, Bromhexine, or similar medicines, as it may cause rash, itching, swelling, or difficulty breathing. Inform about your condition to your doctor. 

Heart problems

People with heart disease should avoid medicines containing terbutaline as it can increase heart rate, cause palpitation, or may worsen heart condition. 

High Blood Pressure

If you have high blood pressure, this medicine may raise it further due to Terbutaline, increasing the risk of complications. 

Hyperthyroidism

Those with an overactive thyroid should avoid it as Terbutaline can worsen symptoms like rapid heartbeat, nervousness, and tremors. 

Stomach Ulcers

Patients with stomach or gastric ulcers should use caution because Ambroxol may irritate the stomach lining and worsen ulcers. 

Pregnancy

Pregnant women should take this medicine only under doctor supervision, as its safety is not fully established for the fetus. 

Breastfeeding

 If you are breastfeeding, inform your doctor, as this medicine can pass into breast milk and affect the baby. 

Guaifenesin + Terbutaline + Bromhexine Interaction with Food Product

Avoid alcohol and caffeine as they may increase dizziness, heartbeat, or nervousness. Spicy, acidic, or very salty foods can irritate the stomach or raise blood pressure. Drinking enough water and eating a balanced diet helps the medicine work better. 

Guaifenesin + Terbutaline + Bromhexine Interaction with Other Medicines

Avoid taking Guaifenesin + Terbutaline + Bromhexine with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Guaifenesin + Terbutaline + Bromhexine Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Guaifenesin: 3-(2-methoxyphenoxy)propane-1,2-diol 

Terbutaline: 5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol 

Bromhexine: 2,4-dibromo-6-[[cyclohexyl(methyl)amino] methyl] aniline 

Intake routine/cycle

Daily dose

Take Guaifenesin + Terbutaline + Bromhexine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

Do not take Guaifenesin + Terbutaline + Bromhexine more than the prescribed dose per day. Overdosing may cause s nausea, vomiting, stomach pain, dizziness, headache, low blood pressure, drowsiness, restlessness, or in rare cases, seizures and breathing difficulty. Seek immediate medical attention if any of these occur.  

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Guaifenesin + Terbutaline + Bromhexine Summary

Guaifenesin, terbutaline, bromhexine is used to treat cough, emphysema, bronchitis, asthma, and COPD. It works by thinning and loosening mucus (Guaifenesin), relaxing airway muscles to ease breathing (Terbutaline), and breaking down thick mucus to help clear it from the lungs (Ambroxol). Common side effects include nausea, vomiting, headache, dizziness, tremors, nervousness, and sweating, while rare effects may include palpitations, chest pain, or allergic reactions.  

People with heart problems, high blood pressure, hyperthyroidism, stomach ulcers, or allergies to its ingredients, as well as pregnant or breastfeeding women, should use it only under doctor supervision. Avoid alcohol, caffeine, very spicy or acidic foods, and foods high in salt. Staying well-hydrated can also help the medicine work more effectively. Overall, this combination helps clear mucus, ease breathing, and relieve cough in respiratory conditions. 

FAQ’s

What are the uses for guaifenesin syrup? 

Guaifenesin syrup is used to loosen and thin mucus in the airways, making it easier to cough out and clear chest congestion. 

What class of drug does guaifenesin belong to? 

Guaifenesin belongs to the class of drugs called expectorants. 

What is the mechanism of action of Terbutaline? 

Terbutaline works by relaxing the muscles in the airways, widening the bronchi, and making breathing easier. 

Is Terbutaline safe during pregnancy? 

Terbutaline should be used in pregnancy only if clearly needed and prescribed by a doctor, as it may affect the mother or baby. 

What class of drug does Terbutaline belong to? 

Terbutaline belongs to the bronchodilator class, specifically a beta-2 adrenergic agonist. 

What are the uses for Bromhexine? 

Bromhexine is used to treat cough with thick mucus by breaking down and thinning the mucus, making it easier to cough out. 

How does Bromhexine work? 

Bromhexine works by breaking down and thinning thick mucus in the airways, which helps clear it from the lungs and makes breathing easier. 

Reference 

1. PubChem. Terbutaline [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Oct 25]. Available from 
2. PubChem. Ambroxol [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Oct 25]. Available from 
3. Ambroxol [Internet]. go.drugbank.com. Available from 
4. Terbutaline Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD [Internet]. www.webmd.com. Available from 
5. 1mg.com. Ambroxol + Guaifenesin + Terbutaline: View Uses, Side Effects and Medicines | 1mg [Internet]. 1mg. 2022 [cited 2025 Oct 25]. Available from 
6. Ambroxol 15mg + Terbutaline 1.25 Mg+Guaifenesin 50mg +Menthol 1 Mg [Internet]. indiamart.com. 2021 [cited 2025 Oct 25]. Available from   

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.