Paracetamol 500 mg + Phenylephrine 10 mg + Chlorpheniramine 2 mg

Category- Allopathy

Medicine Highlights

Paracetamol + Phenylephrine + Chlorpheniramine Uses 

Paracetamol + Phenylephrine + Chlorpheniramine is an oral combination medicine that acts as a pain reliever, decongestant and antihistamine. This medicine is used to prevent and treat conditions like:  

1. Common cold  
2. Fever, headache, and body ache 
3. Allergic symptoms such as itching and watery eyes caused by histamine release  

Directions for use

1. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take this medicine exactly as prescribed by your doctor, at the same time each day.  
3. Do not stop taking this medicine without your doctor’s approval, even if you feel better.

Paracetamol + Phenylephrine + Chlorpheniramine side effects 

More Common  

1. Drowsiness or dizziness (from Chlorpheniramine) 
2. Headache 
3. Nausea or upset stomach 
4. Mild increase in blood pressure or fast heartbeat  

Less Common

1. Allergic reactions like rash, itching, swelling, or difficulty breathing 
2. Severe dizziness or palpitations 
3. Liver problems   

How Paracetamol + Phenylephrine + Chlorpheniramine works 

Paracetamol + Phenylephrine + Chlorpheniramine works by combining three actions in one medicine. Paracetamol reduces fever and pain, making you feel more comfortable. Phenylephrine clears a blocked nose by shrinking swollen blood vessels, while Chlorpheniramine blocks histamine, which helps reduce sneezing, runny nose, and watery eyes. Together, they relieve common cold, flu, and allergy symptoms effectively. 

Safety Measures and Warning 

Allergic Reactions or Hypersensitivity

Do not take this medicine if you are allergic to Paracetamol, Phenylephrine, and Chlorpheniramine, as it may cause rash, itching, swelling, or difficulty breathing. 

Heart or Blood Pressure Problems

People with high blood pressure, heart disease, or irregular heartbeat should avoid it because Phenylephrine can raise blood pressure and strain the heart. 

Liver Problems

Those with liver disease should be cautious, as Paracetamol is processed by the liver and may worsen liver function. 

Glaucoma

Avoid if you have narrow-angle glaucoma, since Chlorpheniramine can increase eye pressure. 

Thyroid or Diabetes Issues

People with overactive thyroid or diabetes should consult a doctor first, as Phenylephrine may affect heart rate or blood sugar. 

Pregnant or breastfeeding women

Only take if prescribed by a doctor, as some ingredients may not be safe in pregnancy or breastfeeding. 

Paracetamol + Phenylephrine + Chlorpheniramine Interaction with Other Medicines

Avoid taking Paracetamol + Phenylephrine + Chlorpheniramine with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Paracetamol + Phenylephrine + Chlorpheniramine Interaction with Food Product

Avoid alcohol and too much caffeine, as they can cause dizziness or fast heartbeat. Drink plenty of water to stay hydrated and ease coughing. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Paracetamol + Phenylephrine + Chlorpheniramine Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Phenylephrine: 3-[(1R)-1-hydroxy-2-(methylamino)ethyl]phenol 

Chlorpheniramine: 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine 

Paracetamol: N-(4-hydroxyphenyl)acetamide 

Intake routine/cycle

Daily dose

Take Paracetamol + Phenylephrine + Chlorpheniramine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

Do not take Paracetamol + Phenylephrine + Chlorpheniramine more than the prescribed dose per day. Overdosing may cause problems such as nausea, vomiting, stomach pain, dizziness, headache, low blood pressure, drowsiness, restlessness, or in rare cases, seizures and breathing difficulty. Seek immediate medical attention if any of these occur.  

Paracetamol + Phenylephrine + Chlorpheniramine Summary 

This combination medicine is used to relieve symptoms of cold, flu, and allergies. Paracetamol helps reduce fever and pain, Phenylephrine clears blocked nose, and Chlorpheniramine reduces sneezing, runny nose, and watery eyes. Common side effects include drowsiness, dizziness, headache, upset stomach, and mild increase in blood pressure. Serious reactions are rare but can occur in people with heart, liver, or allergy-related issues. It should be taken as directed, avoiding alcohol, excessive caffeine, and heavy meals, and always check with a doctor if you have any underlying health conditions. 

FAQ’s

What are the uses for Chlorpheniramine Maleate? 

It is used to relieve allergy symptoms such as runny nose, sneezing, watery eyes, and itching. 

What are the side effects of Phenylephrine? 

Phenylephrine may cause increased blood pressure, fast or irregular heartbeat, nervousness, dizziness, headache, and trouble sleeping. Serious side effects are rare but more likely in people with heart problems or high blood pressure. Always take it as directed by your doctor. 

What class of drug is Phenylephrine? 

Phenylephrine belongs to the decongestant class of drugs. It works by shrinking swollen blood vessels in the nose to relieve nasal congestion. 

What are the side effects of Paracetamol? 

Paracetamol may cause nausea, upset stomach, or mild rash and itching. Rarely, it can lead to severe allergic reactions like swelling, difficulty breathing, or hives, and liver damage if taken in high doses or for a long time. Always follow the recommended dose and consult a doctor if serious symptoms occur. 

How does Paracetamol work? 

Paracetamol reduces pain and fever by acting on the brain to lower body temperature and block pain signals. 

What is the recommended Paracetamol dosage per day? 

For adults, the usual dose is 500–1000 mg every 4–6 hours, not exceeding 4 grams (4000 mg) in 24 hours. Always follow your doctor’s advice and avoid taking multiple medicines containing Paracetamol at the same time. 

Reference 

1. PubChem. Phenylephrine [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
2. PubChem. (+-)-Chlorpheniramine [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Oct 8]. Available from 
3. MedlinePlus. Phenylephrine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019. Available from 
4. drug bank. Chlorpheniramine [Internet]. go.drugbank.com. 2024. Available from 
5. PubChem. Acetaminophen [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
6. France N. Paracetamol [Internet]. Drugs.com. 2023. Available from 
7. 1mg.com. Chlorpheniramine Maleate + Paracetamol + Phenylephrine: View Uses, Side Effects and Medicines | 1mg [Internet]. 1mg. 2023 [cited 2025 Oct Available from 
8. Truemeds [Internet]. Truemeds.in. 2019 [cited 2025 Oct 8]. Available from 

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.