Rosuvastatin 10 mg + Fenofibrate 160 mg

Category- Allopathy

Medicine Highlights

Rosuvastatin + Fenofibrate Uses

Rosuvastatin 10 mg + fenofibrate 160 mg is an oral medicine belonging to the category of lipid-lowering drugs and is used for the following indications:

1. Increased levels of bad cholesterol (hypercholesterolemia) 
2. Clogged fat in arteries (atherosclerosis) 

Rosuvastatin + Fenofibrate side effects 

More Common

1. Chills  
2. Fever  
3. Itching, skin rash  
4. Muscle aches and pains  
5. Nausea  
6. Stomach pain  
7. Vomiting  
8. Runny nose, sneezing; or 
9. Difficulty in moving 
10. Joint pain or swelling 
11. Muscle pain, cramps, spasms, or stiffness 

Less Common 

1. Sharp stomach pain spreading to your back or shoulder blade 
2. Loss of appetite, stomach pain just after eating a meal 
3. Jaundice (yellowing of the skin or eyes) 
4. Fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding 
5. Chest pain, sudden cough, wheezing, rapid breathing, coughing up blood 
6. Swelling, warmth, or redness in an arm or leg 
7. Blurred vision 
8. Chest pain, discomfort, tightness, or heaviness 
9. Difficult, burning, or painful urination 
10. Dry mouth 
11. Fast, irregular, pounding, or racing heartbeat or pulse 
12. Flushed, dry skin 
13. Fruit-like breath odor 
14. Increased hunger 
15. Increased thirst 
16. Increased urination 
17. Loss of consciousness 
18. Muscle tension or tightness 
19. Nausea 
20. Slow heartbeat 
21. Stomachache 
22. Sweating 
23. Trouble breathing 
24. Unexplained weight loss 
25. Unusual tiredness or weakness 
26. Vomiting 

How Rosuvastatin + Fenofibrate works 

Rosuvastatin and fenofibrate work together like a cleanup crew for your blood vessels. Rosuvastatin slows down the body’s production of bad cholesterol and helps clear clogged arteries. Fenofibrate targets a different type of fat called triglycerides and boosts good cholesterol, improving blood flow.

Safety Measures and Warning 

Pregnancy

Fenofibrate can harm a developing fetus, with animal studies showing growth and skeletal issues and due to limited human data, it’s avoided in pregnancy unless essential, and medical advice is required.

Breastfeeding

Trace amounts of rosuvastatin and fenofibrates can pass through breast milk. Tell your health care provider if you are breastfeeding or plan to breastfeed. Your health care provider will let you know if you should stop breastfeeding or stop fenofibrate.

Kidney and Liver Problems

Rosuvastatin and fenofibrates can affect the liver’s functioning by causing changes in liver enzymes and can lead to severe toxicity and liver damage. So, take the medicine only when the doctor recommends it. 

Rosuvastatin + Fenofibrate Interaction with Food Product 

Alcohol and smoking can interact with the medicine, simultaneously affecting the drug’s action, and can cause an increase or decrease in the drug’s action.

Rosuvastatin + Fenofibrate Interaction with Other Medicines  

Avoid taking Rosuvastatin 10 mg + Fenofibrate 160 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Rosuvastatin + Fenofibrate Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Rosuvastatin-(3R,5S,6E) -7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-propan-2-ylpyrimidin-5-yl] -3,5-dihydroxyhept-6-enoic acid

Fenofibrate-2-[4-(4-chlorobenzoyl) phenoxy] -2-methylpropanoic acid isopropyl ester

Intake routine/cycle

Daily dose

Take Rosuvastatin + Fenofibrate exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 40 mg of rosuvastatin and 160 mg of fenofibrate per day, as it may cause severe overdosing effects like liver damage, kidney damage, pancreatitis, muscle problems, nausea, and muscle problems. If you face any of the severe effects, consult  the doctor.

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take Rosuvastatin + Fenofibrate exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Rosuvastatin + Fenofibrate without your doctor’s approval, even if you feel better. 
3. If you forget to take Rosuvastatin + Fenofibrate, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Rosuvastatin + Fenofibrate Summary 

This medication consists of two active ingredients that work together to lower harmful cholesterol and blood fats. blocks the production of bad cholesterol, whereas fenofibrate breaks down the existing bad cholestrol. This combo helps protect the heart but may cause side effects like tiredness, stomach upset, or muscle pain and, rarely, serious muscle damage. It’s not safe for those with liver, kidney, or gallbladder issues, during pregnancy, or if they’ve had bad reactions to similar drugs. Avoid alcohol, eat vitamin K-rich foods with care, and take fenofibrate + rosuvastatin with food to get the maximum effect. Rosuvastatin is safe up to 40 mg/day and fenofibrate up to 200 mg/day, with no defined overdose threshold; exceeding these limits is unsafe and managed with supportive care.

FAQ’s

What are the uses of the rosuvastatin 10 mg and fenofibrate 160 mg combination medicine?

Rosuvastatin 10 mg + fenofibrate 160 mg is an oral medicine belonging to the category of lipid-lowering drugs and is used for the treatment of Increased levels of bad cholesterol (hypercholesterolemia) and Clogged fat in arteries (atherosclerosis)

What is the price of rosuvastatin and fenofibrate tablets?

At Saya Care, rosuvastatin 10 mg + fenofibrate 160 mg costs 31 rupees for 10 tablets. They are used to control fat and cholesterol in the body and to improve heart health.

What are the side effects of rosuvastatin and fenofibrate?

Rosuvastatin and fenofibrate are medicines that work together to lower harmful cholesterol and blood fats. This may cause side effects like tiredness, stomach upset, or muscle pain and, rarely, serious muscle damage.

Reference 

1. The Health Site. How to lower cholesterol in one week: 10 Indian foods to lower cholesterol naturally at home. TheHealthSite.com. 2024 [cited 2024 Nov 2]. Available from. 
2. Hoogwerf BJ. Statins may increase diabetes, but benefit still outweighs risk. Cleveland Clinic Journal of Medicine. 2023 Jan 3;90(1):53-62. Available from. 
3. Drugs.com. Fenofibrate [Internet]. Drugs.com; 2024 [cited 2025 Jul 16]. Available from. 
4. WebMD. Fenofibrate oral: Uses, side effects, interactions and more [Internet]. WebMD; 2025 [cited 2025 Jul 16]. Available from. 
5. National Center for Biotechnology Information. Fenofibrate [Internet]. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012 [cited 2025 Jul 16]. Available from. 
6. Mayo Clinic. Fenofibrate (Oral Route) Description and Brand Names [Internet]. Mayo Foundation for Medical Education and Research; 2024 [cited 2025 Jul 16]. Available from. 
7. National Center for Biotechnology Information. PubChem Compound Summary for CID 3339, Fenofibrate [Internet]. PubChem; 2004 [cited 2025 Jul 16]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.