Acotiamide 300 mg (ER)

Category- Allopathy

Medicine Highlights

Acotiamide Uses

Acotiamide 300 mg is an oral medicine belonging to the category of prokinetics and is used to treat stomach discomfort due to dyspepsia.

Acotiamide side effects

More Common

1. Headache  
2. Diarrhea 
3. Constipation 
4. Nausea 
5. Vomiting 
6. Skin rash 
7. Dizziness 
8. Abdominal discomfort or pain 
9. Flatulence 

Less Common

1. Severe allergic reactions 
2. Changes in liver function 
3. Severe Skin rash 

How Acotiamide works

Acotiamide helps your stomach work better by keeping more of a natural chemical called acetylcholine active. This chemical tells your stomach muscles to move food along properly. By stopping the enzyme that breaks it down, acotiamide lets your stomach empty slowly. It may also slightly increase a hormone called gastrin, which helps with digestion. Overall, it eases common problems like bloating, heaviness, and discomfort after eating, especially in people with functional dyspepsia.

Safety Measures and Warning

Pregnancy

Acotiamide is not recommended during pregnancy unless clearly needed, as there’s limited safety data available for its use in pregnant women. Animal studies have shown that very high doses may lead to effects like reduced body weight and premature labor; it should be used only when needed under recommended conditions only by the doctors.

Breastfeeding

Acotiamide passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop Acotiamide.

Liver Problems

Acotiamide should be used with caution in people who have liver problems, because liver disease can affect how the body processes the medication. In some cases, it can cause a change in liver functioning, so don’t use this, as it can put your liver to work and further damage it.

Acotiamide Interaction with Food Product

Avoid smoking and consuming alcohol, as they can either increase or decrease the drug’s action. 

Acotiamide Interaction with Other Medicines

Avoid taking acotiamide 300 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Acotiamide Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide 

Intake routine/cycle

Daily Dose

Take acotiamide exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

Don’t take more than 300 mg of acotiamide per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, high blood pressure, hallucinations, confusion, and slurred speech. Immediately seek medical care in case of any overdose symptoms. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use

1. Take acotiamide exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking acotiamide without your doctor’s approval, even if you feel better. 
3. If you forget to take acotiamide, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Acotiamide Summary 

Acotiamide is a medicine used to help people who often feel stomach full too quickly, bloated, or have stomach discomfort after eating. This condition is called functional dyspepsia. It works by helping your stomach muscles move food along more easily, so your stomach empties faster. You usually take it before meals. Some people may feel mild side effects like headaches, nausea, or changes in bowel movements like constipation or diarrhea. It’s not meant for people who are allergic to it, pregnant, breastfeeding, or have serious liver or kidney problems unless their doctor says otherwise. It’s best to avoid alcohol or mixing it with other medicines without asking a doctor first.

FAQ’s

What are the uses of acotiamide tablet ?

Acotiamide is a medicine used to help people who often feel stomach full too quickly, bloated, or have stomach discomfort after eating. This condition is called functional dyspepsia.

What are the side effects of acotiamide tablet?

Some people may feel mild side effects like headaches, nausea, or changes in bowel movements like constipation or diarrhea while using acotiamide.

What are acotiamide medicine brand names?

Acotiamide has different brand names that are endorsed by marketing companies, but the salt name remains the same. Many of the brands fail to pass the Central Drug Standard Control Organization standard quality test, and it’s the time when Saya Care steps in, and we provide the medicine with a quality test report and at a price 80% off.

What is the maximum acotiamide dose per day?

It is not recommended to take more than 300 mg of acotiamide per day, as it may cause severe overdosing effects like diarrhea, kidney and liver damage, heart problems, and allergies. If you face any of the severe effects, take him to the doctor.

Reference

1. National Center for Biotechnology Information (NCBI). Acotiamide [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 23]. Available from. 
2. Wikipedia contributors. Acotiamide [Internet]. Wikipedia, The Free Encyclopedia; [cited 2025 Jul 23]. Available from. 
3. DrugBank Online. Acotiamide [Internet]. Edmonton (AB): DrugBank; [cited 2025 Jul 23]. Available from. 
4. ScienceDirect Topics. Acotiamide [Internet]. Amsterdam: Elsevier; [cited 2025 Jul 23]. Available from. 
5. Practo. Acotiamide [Internet]. Bangalore: Practo Technologies Pvt Ltd; [cited 2025 Jul 23]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.