Amoxycillin 875 mg + Clavulanic Acid 125mg

Category- Allopathy

Medicine Highlights

Amoxicillin + Clavulanic Acid Uses 

Amoxicillin + Clavulanic Acid is an antibiotic medicine that belongs to the class of penicillins. It is used to kill bacteria and treat symptoms of conditions like: 

1. Throat infections such as tonsillitis and pharyngitis 
2. Ear infections (otitis media) 
3. Sinus infections 
4. Chest infections like bronchitis and pneumonia 
5. Urinary tract infections (UTIs) 
6. Skin and soft-tissue infections 
7. Dental infections 

Directions for use

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Amoxicillin + Clavulanic Acid side effects 

More Common  

1. Nausea 
2. Vomiting 
3. Diarrhea 
4. Stomach pain or upset 
5. Headache 
6. Mild skin rash or itching    

Less Common

1. Severe allergic reactions (swelling, difficulty breathing, hives) 
2. Severe diarrhea (C. difficile infection) 
3. Liver problems (jaundice, dark urine) 
4. Dizziness or fainting 
5. Yeast infections     

How Amoxicillin + Clavulanic Acid works 

Amoxicillin works by blocking bacterial cell wall formation (amoxicillin) while clavulanic acid inhibits the formation of bacterial enzymes (beta-lactamases) that destroy amoxicillin. This combination makes it effective against bacteria resistant to amoxicillin alone. 

Safety Measures and Warning 

Allergy or hypersensitivity

If you are allergic to this medication, avoid taking it as it can cause some serious side effects like breathing problems, wheezing, skin rashes, swelling, or serious allergic reactions. Always inform your doctor if you have had any reaction to antibiotics before using this medicine. 

Kidney Problems

Use Amoxicillin + Clavulanic Acid with caution if you have severe kidney disease, as the medicine may build up in your body and increase side effects. Dose adjustment may be required. 

Liver Problems

Use with caution if you have liver disease, as liver diseases will reduce the metabolism and can lead to toxicity or side effects. Always communicate with your doctor about your past disease history. 

History of Antibiotic-Associated Diarrhea

 Avoid if you previously developed severe diarrhea or any gut infection caused by bad bacteria (i.e. C. difficile) after taking antibiotics, unless your doctor decides it’s necessary. 

Amoxicillin + Clavulanic Acid Interaction with Food Product

Amoxicillin + Clavulanic Acid can be taken with or without food. Taking it with meals may help reduce stomach upset. Avoid alcohol if it worsens nausea or dizziness. Drink plenty of water to help the body absorb and eliminate the medicine properly. 

Amoxicillin + Clavulanic Acid Interaction with Other Medicines

Avoid taking Amoxicillin + Clavulanic Acid with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Amoxicillin + Clavulanic Acid Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Amoxicillin: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Clavulanic Acid: (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Intake routine/cycle

Daily dose

Take Amoxicillin + Clavulanic Acid exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

It is not recommended to take Amoxicillin + Clavulanic Acid more than 500 mg per day. Overdose may cause tremors, chest pain, fast or irregular heartbeat, nervousness, dizziness, headache, muscle cramps, or high blood pressure. In case of any of these symptoms, seek immediate medical help. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Amoxicillin + Clavulanic Acid Summary

Amoxicillin and Clavulanic Acid are penicillin-class antibiotic used to treat bacterial infections such as throat infections (tonsillitis, pharyngitis), ear infections (otitis media), sinus infections, chest infections like bronchitis and pneumonia, urinary tract infections (UTIs), skin and soft-tissue infections, dental infections, and infections caused by bacteria resistant to amoxicillin alone. It works by blocking bacterial cell wall formation (amoxicillin) and inhibiting bacterial enzymes (beta-lactamases) that destroy amoxicillin (clavulanic acid), making it effective against resistant bacteria. Common side effects include nausea, vomiting, diarrhea, stomach pain, headache, and mild rash, while rare serious effects may include severe allergic reactions, liver problems, severe diarrhea, dizziness, and yeast infections. 

It should not be taken by people allergic to penicillin or cephalosporins and should be used with caution in those with kidney or liver problems, severe allergies, or a history of antibiotic-related diarrhea. The medicine can be taken with or without food, and intake of alcohol should be avoided. It is generally considered safe during pregnancy if prescribed by a doctor.   

FAQ’s

What are the uses of Amoxicillin + Clavulanic Acid? 

Amoxicillin + Clavulanic Acid is used to treat bacterial infections such as throat infections (tonsillitis, pharyngitis), ear infections (otitis media), sinus infections, chest infections like bronchitis and pneumonia, urinary tract infections (UTIs), skin and soft-tissue infections, dental infections, and infections caused by bacteria resistant to amoxicillin alone. 

What are the side effects of Amoxicillin + Clavulanic Acid? 

Common side effects include nausea, vomiting, diarrhea, stomach pain, headache, and mild skin rash. Rare but serious side effects may include severe allergic reactions (swelling, difficulty breathing, hives), liver problems, severe diarrhea (C. difficile infection), dizziness, and yeast infections. Seek medical help if severe symptoms occur. 

What is the mechanism of action of Amoxicillin + Clavulanic Acid? 

Amoxicillin + Clavulanic Acid works by killing bacteria. Amoxicillin blocks bacterial cell wall formation, causing bacteria to break down and die, while clavulanic acid inhibits bacterial enzymes (beta-lactamases) that can destroy amoxicillin. This combination makes it effective against bacteria resistant to amoxicillin alone. 

Is Amoxicillin + Clavulanic Acid safe during pregnancy? 

Amoxicillin + Clavulanic Acid is generally considered safe to use during pregnancy if clearly needed. It should only be taken under a doctor’s guidance. Always inform your doctor if you are pregnant before starting this medicine. 

Who should not take Amoxicillin + Clavulanic Acid? 

Amoxicillin + Clavulanic Acid should not be taken by people who are allergic to amoxicillin, clavulanic acid, penicillins, or cephalosporins. It should be used with caution in those with severe kidney or liver problems, history of antibiotic-related diarrhea, or severe allergies. Always consult a doctor before taking this medicine if any of these conditions apply.

Reference 

1. Uto LR, Gerriets V. Clavulanic Acid [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2020. Available from 
2. PubChem. Amoxicillin [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
3. Augmentin dosage guide [Internet]. Drugs.com. 2024. Available from 
4. Amoxicillin And Clavulanate (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. www.mayoclinic.org. Available from 
5. Augmentin, Augmentin XR (amoxacillin/clavulanate) dosing, indications, interactions, adverse effects, and more [Internet]. reference.medscape.com. Available from 

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.