Amoxicillin 250 mg + Cloxacillin 250 mg

Category- Allopathy

Medicine Highlights

Amoxicillin + Cloxacillin Uses

Amoxicillin + Cloxacillin is an antibiotic medicine that belongs to the class of penicillin’s. It is used to kill bacteria and treat symptoms of conditions like: 

1. Throat infections such as tonsillitis and pharyngitis 
2. Ear infections (otitis media) 
3. Sinus infections 
4. Chest infections like bronchitis and pneumonia 
5. Urinary tract infections (UTIs) 
6. Skin and soft-tissue infections 
7. Dental infections      

Amoxicillin + Cloxacillin side effects 

More Common  

1. Nausea 
2. Vomiting 
3. Diarrhea 
4. Stomach pain 
5. Skin rash   

Less Common 

1. Headache or dizziness 
2. Oral or vaginal fungal infection    

How Amoxicillin + Cloxacillin works 

Amoxicillin works by preventing bacteria from building their protective outer wall. Without this wall, the bacteria become weak and break apart, which kills them. Cloxacillin also stops bacteria from forming this protective wall. Because of this, this combination can kill certain resistant bacteria and help clear the infection effectively. 

Safety Measures and Warning 

Allergy/Hypersensitivity

 If you are allergic to this medication, taking it as it can cause some serious side effects like breathing problems, wheezing, skin rashes, swelling, or serious allergic reactions. Always inform your doctor if you have had any reaction to antibiotics before using this medicine. 

Kidney Problems

If you have severe kidney disease, communicate with your doctor, as the medicine may build up in your body and increase side effects. Dose adjustment may be required. 

Liver Problems

Always communicate with your doctor about your past disease history, as liver diseases will reduce the metabolism and can lead to toxicity or side effects.

History of Antibiotic-Associated Diarrhea

Avoid if you previously developed severe diarrhea or any gut infection caused by bad bacteria (i.e. C. difficile) after taking antibiotics, unless your doctor decides it’s necessary.   

Amoxicillin + Cloxacillin Interaction with Food Product 

Amoxicillin + Cloxacillin can be taken with or without food. Taking it with meals may help reduce stomach upset. Avoid alcohol if it worsens nausea or dizziness. Drink plenty of water to help the body absorb and eliminate the medicine properly. 

Amoxicillin + Cloxacillin Interaction with Other Medicines  

Avoid taking Amoxicillin + Cloxacillin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Amoxicillin + Cloxacillin Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Amoxicillin: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Cloxacillin: (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Intake routine/cycle

Daily dose

Take Amoxicillin + Cloxacillin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

 It is not recommended to take Amoxicillin + Cloxacillin more than 500 mg per day. Overdose may cause tremors, chest pain, fast or irregular heartbeat, nervousness, dizziness, headache, muscle cramps, or high blood pressure. In case of any of these symptoms, seek immediate medical help. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.  

Amoxicillin + Cloxacillin Summary 

Amoxicillin and cloxacillin are penicillin antibiotics used together to treat bacterial infections. They work by stopping bacteria from forming their protective cell wall, which leads to bacterial death. Amoxicillin is effective against a broad range of bacteria, while cloxacillin is resistant to penicillinase enzymes, making it useful against certain penicillin-resistant strains, especially Staphylococcus aureus.  

This combination is commonly prescribed for skin, soft tissue, respiratory, and wound infections. It is usually well tolerated but may cause stomach upset, diarrhea, or mild rashes. The medicine should be taken exactly as prescribed, and the full course must be completed to ensure complete infection clearance and to prevent antibiotic resistance. 

FAQ’s

What is the usual dosage of Amoxicillin + Cloxacillin? 

The usual adult dose is 250 mg amoxicillin + 250 mg cloxacillin, taken 2–3 times daily after food, for 5–7 days or as prescribed by the doctor. The dose for children varies based on age and weight and should be given only on medical advice. Missed doses should not be doubled. 

What are the uses of Amoxicillin + Cloxacillin? 

It is an antibiotic combination used to treat bacterial infections, especially those affecting the skin, soft tissues, respiratory tract, bones, and wounds.

What are the side effects of amoxicillin? 

 Common side effects of amoxicillin include nausea, vomiting, diarrhea, stomach pain, and mild skin rash. Less commonly, it may cause headache or fungal infections. Rare but serious reactions include allergic responses (swelling, itching, breathing difficulty), severe diarrhea, or liver-related problems, which require immediate medical attention. 

Is amoxicillin safe to use during pregnancy? 

Amoxicillin is generally considered safe during pregnancy when prescribed by a doctor. It should be used only if clearly needed and in the recommended dose, as the doctor will weigh the benefits against any possible risks to the mother and baby. 

What are the uses of cloxacillin? 

Cloxacillin is used to treat bacterial infections, especially skin and soft tissue infections, bone and joint infections, respiratory infections, and wound infections caused by penicillin-resistant bacteria such as Staphylococcus aureus. 

Which generation does cloxacillin belong to? 

Cloxacillin belongs to the first-generation penicillin group, specifically the penicillinase-resistant (antistaphylococcal) penicillins. 

Reference 

1. PubChem. Cloxacillin [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Jan 30]. Available from 
2. Welcome To Zscaler Directory Authentication [Internet]. Drugs.com. 2026 [cited 2026 Feb 14]. Available from

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.