Cefixime 200 mg + Clavulanic acid 125 mg

Category- Allopathy

Medicine Highlights

Cefixime + Clavulanic acid Uses

Cefixime + Clavulanic acid is an antibiotic medicine. It is used to kill bacteria and treat symptoms of conditions like: 

1. Throat infections such as tonsillitis, pharyngitis, bronchitis and pneumonia 
2. Ear infections (otitis media) 
3. Sinus infections 
4. Urinary tract infections (UTIs) 
5. Skin and soft-tissue infections 
6. Dental infections 
7. Typhoid fever  

Cefixime + Clavulanic acid side effects 

More Common  

1. Diarrhea or loose stools 
2. Nausea or vomiting 
3. Stomach pain or indigestion 
4. Gas or bloating 
5. Headache  

Less Common 

1. Skin rash or itching 
2. Mild allergic reaction 
3. Vaginal yeast infection 

How Cefixime + Clavulanic acid works 

Cefixime kills bacteria by rupturing the skin of bacteria, by which bacteria die. To increase the effect of cefixime clavulanic acid works by blocking the bacteria’s protective enzyme. Resulting in synergistic effect. Clavulanic acid blocks this enzyme, protecting cefixime so it can continue killing the bacteria. As a result, the combination works effectively to clear the infection and help the patient recover. 

Safety Measures and Warning 

Allergy/Hypersensitivity

If you are allergic to this medication, as taking it can cause some serious side effects like breathing problems, wheezing, skin rashes, swelling, or serious allergic reactions. Always inform your doctor if you had experienced any reaction to antibiotics before using this medicine. 

Kidney Problems

If you have severe kidney disease, communicate with your doctor, as the medicine may build up in your body and increase side effects.    

Liver Problems

Always communicate with your doctor about your past disease history, as liver diseases will reduce the metabolism and can lead to toxicity or side effects.  

History of Antibiotic-Associated Diarrhea

Avoid if you previously developed severe diarrhea or any gut infection caused by bad bacteria (i.e. C. difficile) after taking antibiotics, unless your doctor decides it’s necessary.   

Cefixime + Clavulanic acid Interaction with Food Product 

Avoid alcohol as it worsens nausea or dizziness. Drink plenty of water to help the body absorb and eliminate the medicine properly. 

Cefixime + Clavulanic acid Interaction with Other Medicines  

Avoid taking Cefixime + Clavulanic acid with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Cefixime + Clavulanic acid Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Cefixime: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethoxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Clavulanic acid: (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 

Intake routine/cycle

Daily dose

Take Cefixime + Clavulanic acid exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take Cefixime + Clavulanic acid more than the prescribed amount. Overdose may cause tremors, chest pain, fast or irregular heartbeat, nervousness, dizziness, headache, muscle cramps, or high blood pressure. In case of any of these symptoms, seek immediate medical help. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take spironolactone exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking spironolactone without your doctor’s approval, even if you feel better. 
3. If you forget to take spironolactone, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Cefixime + Clavulanic acid Summary 

Cefixime + Clavulanic acid is an antibiotic combination used to treat bacterial infections such as respiratory, urinary, ear, throat, skin, dental infections, and sometimes typhoid fever. Cefixime kills bacteria by rupturing the skin of the bacteria, while clavulanic acid blocks bacterial substances that cause antibiotic resistance, allowing cefixime to work effectively. Common side effects include diarrhea, nausea, stomach pain, and headache, while serious allergic reactions are rare.  

This medicine should not be taken by people allergic to this medicine and should be used with caution in those with kidney or liver problems. It should be taken after food, and the full course must be completed for proper treatment. 

FAQ’s

What are the side effects of Cefixime?  

Common side effects include diarrhea, nausea, stomach pain, gas, and skin rash. 

What is the adult dosage for Cefixime?  

The usual dose is 200 mg twice daily or 400 mg once daily, as prescribed by the doctor.  

What is the pediatric dose of Cefixime?  

The usual dose is 8 mg/kg/day, given once or in two divided doses, as prescribed by the doctor based on the child’s weight and condition. 

What is the mechanism of action of Clavulanic Acid?  

 Clavulanic Acid works by inhibiting bacterial beta-lactamase enzymes, which normally destroy antibiotics like amoxicillin. By blocking these enzymes, it protects the antibiotic and allows it to effectively kill bacteria.

What are the uses of Clavulanic Acid?

 Clavulanic Acid is used in combination with antibiotics like amoxicillin to treat bacterial infections. It helps treat infections such as throat infections, ear infections, sinus infections, chest infections, urinary tract infections, skin and soft-tissue infections, dental infections, and infections caused by bacteria resistant to amoxicillin alone.  

What are the side effects of Clavulanic Acid?  

Common side effects include nausea, vomiting, diarrhea, stomach pain, and mild skin rash. Rare but serious side effects may include severe allergic reactions (swelling, hives, difficulty breathing), severe diarrhea (C. difficile infection), liver problems (jaundice, dark urine), dizziness, or yeast infections. Seek medical help if severe symptoms occur. 

Reference 

1. Cefixime [Internet]. go.drugbank.com. Available from 
2. Beumer HM. Cefixime versus amoxicillin/clavulanic acid in lower respiratory tract infections. International journal of clinical pharmacology, therapy, and toxicology [Internet]. 1989 Jan;27(1):30–3. Available from 
3. Cefixime (oral route) [Internet]. Mayo Clinic. 2024. Available from  
4. PubChem. Clavulanic acid [Internet]. pubchem.ncbi.nlm.nih.gov. Available from

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.