Serratiopeptidase 10 mg

Category- Allopathy

Medicine Highlights

Serratiopeptidase Uses 

Serratiopeptidase 10 mg is an anti-inflammatory enzyme medicine that helps reduce swelling and inflammation. It is commonly used for: 

1. Pain and inflammation 
2. Throat pain 
3. Sinus (sinusitis) 
4. Joint pain 
5. Muscle pain 
6. Dental pain and swelling 
7. Injury-related swelling   

Directions for use

1. Take this medicine exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Serratiopeptidase side effects

More Common

1. Nausea 
2. Vomiting 
3. Stomach discomfort 
4. Diarrhea 
5. Loss of appetite         

Less common 

1. Skin rash 
2. Itching 
3. Allergic reaction 
4. Breathing difficulty 
5. Increased risk of bleeding     

How Serratiopeptidase works

Serratiopeptidase works by breaking down certain proteins at the site of inflammation. It helps reduce swelling by dissolving inflammatory substances and improving the drainage of fluid from swollen tissues. By decreasing inflammation and pressure in the affected area, it helps relieve pain and promotes faster healing.   

Safety Measures and Warning 

Allergy/Hypercreativity

If you are allergic to Serratiopeptidase or similar enzyme medicines, taking this medicine may cause skin rash, itching, swelling, or breathing difficulty. Hence, inform your doctor if you have any history of allergy before taking this medicine. 

Bleeding Disorders

If you have a bleeding disorder, this medicine may increase the risk of bleeding or bruising. Hence, inform your doctor before use. 

Stomach Ulcer

If you have a history of stomach ulcers, this medicine may worsen your condition. Hence, inform your doctor before taking it.

Pregnancy

Taking this medicine during the last trimester of pregnancy may harm the fetus. Hence, consult your doctor before using it. 

Serratiopeptidase Interaction with other Medicines

Avoid taking Serratiopeptidase with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Serratiopeptidase Interaction with Food Products

Serratiopeptidase is usually taken on an empty stomach (at least 30 minutes before food or 2 hours after meals) for better absorption. There are no major known food interactions, but it is advisable to avoid alcohol as it may increase the risk of stomach discomfort or bleeding. Always follow your doctor’s instructions regarding how to take this medicine. 

Storage   

1. The medicine should be stored at room temperature.  
2. Keep away from sunlight and moisture.
3. Keep away from the reach of children. 

Serratiopeptidase Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Serratiopeptidase: (11Z)-17-hydroxy-2-phenyl-9-oxa-1,5,14,21-tetrazatetracyclo[12.7.1.0^3,8.0^16,21]docosa-3(8),4,6,11,16,19-hexaene-15,18-dione  

Intake routine/cycle 

Daily Dose

Take Serratiopeptidase exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take Serratiopeptidase more than the prescribed dose (usually not exceeding 60 mg per day, depending on the doctor’s advice). Overdose may cause nausea, vomiting, stomach discomfort, diarrhea, skin rash, or an increased risk of bleeding and bruising. In case of any unusual or severe symptoms, seek immediate medical help. 

Serratiopeptidase Summary

Serratiopeptidase 10 mg is a proteolytic enzyme used to reduce swelling, inflammation, and pain. It is commonly prescribed for post-surgical swelling, throat pain, sinusitis, joint pain, muscle pain, dental swelling, and injury-related inflammation. It works by breaking down inflammatory proteins and reducing fluid accumulation at the affected area, which helps relieve pain and supports faster healing. It is usually taken on an empty stomach for better absorption. 

The usual maximum recommended dose should not exceed 60 mg per day, unless advised by a doctor. Taking more than the prescribed amount may increase the risk of side effects such as nausea, vomiting, stomach discomfort, rash, or bleeding. It should be used cautiously in patients with bleeding disorders and during pregnancy only if prescribed by a doctor.   

FAQ’s 

What are the side effects of Serratiopeptidase? 

Serratiopeptidase may cause nausea, vomiting, stomach discomfort, diarrhea, loss of appetite, skin rash, itching, and in rare cases, allergic reactions or increased risk of bleeding. 

What is the mechanism of action of Serratiopeptidase? 

Serratiopeptidase works by breaking down inflammatory proteins at the affected site, which helps reduce swelling, decrease pain, and promote faster healing. 

What is the drug class of Serratiopeptidase? 

 Serratiopeptidase belongs to the class of proteolytic enzymes (anti-inflammatory enzyme agents). 

Can I use Serratiopeptidase during pregnancy? 

Serratiopeptidase is not generally recommended during pregnancy due to limited safety data. It should be used only if clearly prescribed by a doctor after assessing the benefits and risks. 

Reference

1. Serrapeptase Uses, Benefits & Dosage Herbal Database [Internet]. Drugs.com. 2024. Available from 
2. Jadhav SB, Shah N, Rathi A, Rathi V, Rathi A. Serratiopeptidase: Insights into the therapeutic applications. Biotechnology Reports. 2020 Dec;28:e00544.  
3. PubChem. Serrapeptase [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Feb 24]. Available from 
4. SERRAPEPTASE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews [Internet]. www.webmd.com. Available from   

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.