Repaglinide 0.5 mg + Voglibose 0.3 mg

Category- Allopathy

Medicine Highlights

Repaglinide + Voglibose Uses

Repaglinide 0.5 mg + voglibose 0.3 mg is an oral medicine belonging to the category of antidiabetic drugs and is used for the management of type 2 diabetes mellitus.

Repaglinide + Voglibose side effects 

More Common  

1. Low blood sugar (see below) 
2. Infection in the nose or throat, sore throat 
3. Headache 
4. Stuffy or runny nose 
5. Joint pain 
6. Nausea 
7. Diarrhea 
8. Back pain 
9. Cough or hoarseness  
10. Decreased appetite  
11. Diarrhea  
12. Fast or shallow breathing  
13. Fever or chills  
14. General feeling of discomfort  
15. Lower back or side pain  
16. Muscle pain or cramping  
17. Painful or difficult urination  
18. Sleepiness 

Less Common 

1. Breathing problems or wheezing 
2. Racing heart 
3. Fever or general ill feeling 
4. Swollen lymph nodes 
5. Swelling of the face, lips, mouth, tongue, or throat 
6. Trouble swallowing or throat tightness 
7. Itching, skin rash, or pale red bumps on the skin called hives 
8. Nausea or vomiting 
9. Dizziness, feeling lightheaded, or fainting 
10. Stomach cramps 
11. Joint pain 
12. Suicidal thoughts 
13. Hallucinations 
14. Headache 
15. Crankiness or anxiety 
16. Hunger 
17. Dizziness or confusion 
18. Blurry vision 
19. Slurred speech 
20. Sweating 
21. Feeling jittery or shakiness 
22. Fast heartbeat 
23. Seizures 
24. Anxiety 
25. Blurred vision 
26. Chest discomfort 
27. Cold sweats 
28. Coma 
29. Confusion 
30. Cool, pale skin 
31. Depression 
32. Difficult or labored breathing 
33. Dizziness 
34. Fast, irregular, pounding, or racing heartbeat or pulse 
35. Feeling of warmth 
36. Headache 
37. Increased hunger 
38. Increased sweating 
39. Nausea 
40. Nervousness 
41. Nightmares 
42. Redness of the face, neck, arms, and occasionally, upper chest 
43. Shakiness 
44. Slurred speech 
45. Tightness in the chest 
46. Unusual tiredness or weakness 

How Repaglinide + Voglibose works 

Repaglinide and voglibose work by lowering blood sugar in two ways: repaglinide makes the pancreas release insulin quickly after meals to handle sudden sugar spikes, while voglibose reduces extra sugar production by the liver and helps muscles use insulin better; together, they control both mealtime surges and background sugar levels.

Safety Measures and Warning 

Pregnancy

Due to a lack of studies on the effects of repaglinide and voglibose on the fetus during pregnancy, its safety is not clearly established. Therefore, if you are pregnant or planning to conceive, inform your doctor.

Breastfeeding

Repaglinide and voglibose pass into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop repaglinide.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the drug is made into a less toxic form in the liver and kidney, leading to strain on the liver and kidney, causing toxicity, so consult a doctor before using it.

Repaglinide + Voglibose Interaction with Food Product 

Avoid alcohol and smoking while on Repaglinide and Voglibose , as they strain the liver and pancreas and can disturb blood sugar control, sometimes raising it, sometimes lowering it.

Repaglinide + Voglibose Interaction with Other Medicines  

Avoid taking Repaglinide 0.5 mg + Voglibose 0.3 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Repaglinide + Voglibose Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Repaglinide-2-ethoxy-4-[2-[3-methyl -1-[2-(1-piperidinyl)phenyl]butyl]amino] benzoic acid

Voglibose- (1S,2S,3R,4S,5S) -5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol

Intake routine/cycle

Daily dose

Take repaglinide and voglibose exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 3 tablets of 0.50 mg of repaglinide and 0.3 mg of voglibose per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, low blood pressure, unconsciousness, sweating, and seizures. Immediately give the person fruit or glucose-containing liquids and sugary foods to minimize the effects. If you face any of the severe effects, seek medical help.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children. 

Directions for use 

1. Take repaglinide and voglibose exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking repaglinide and voglibose without your doctor’s approval, even if you feel better. 
3. If you forget to take repaglinide and voglibose, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Repaglinide + Voglibose Summary 

Repaglinide and voglibose are oral diabetes medicines that work together to control blood sugar after meals. Repaglinide prompts quick insulin release from the pancreas, while voglibose slows sugar absorption in the gut; like one opens the insulin tap, the other closes the sugar absorption gate. Taken before meals, they help prevent sugar spikes but may cause gas or low sugar if meals are skipped. Alcohol and heavy carbs can worsen side effects. Patients with type 1 diabetes, diabetic ketoacidosis, or those taking gemfibrozil, should avoid taking this medication. Taking more than 2 mg of this medicine can cause severe overdosing effects like extreme drowsiness, confusion, low blood pressure, unconsciousness, sweating, and seizures.

FAQ’s

What is the mechanism of action of repaglinide?

Repaglinide is an antidiabetic medicine used to control high blood glucose levels, and it acts by stimulating the pancreas to stimulate more insulin that controls the blood sugar levels

What is the drug class of repaglinide?

Repaglinide belongs to the category of meglitinides, the antidiabetic drugs used to control blood glucose levels in the body effectively immediately after a meal.

What are the uses of Voglibose 250 mg?

Voglibose 250 mg is a medicine belonging to the biguanides and used to control blood glucose levels and sometimes used in females for polycystic ovarian syndrome.

What is the drug class of the Voglibose tablet?

Voglibose belongs to the class of biguanides used to treat diabetes and control blood sugar levels.

What is the mechanism of action of Voglibose Tablets?

Voglibose lowers blood sugar mainly by reducing glucose production in the liver and improving insulin sensitivity in muscles and fat, helping the body use sugar more effectively. It does this by activating the cell’s energy sensor AMPK, which shifts the body into a “use fuel wisely” mode without causing low sugar.

Reference 

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 65981, Repaglinide. Internet. Bethesda (MD): National Library of Medicine (US); [cited 0.0.3.55 Jul 5]. Available from. 
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3. Mawhinney S, Gaddey HL. Repaglinide. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 0.0.3.53 Jan– [cited 0.0.3.55 Jul 5]. Available from. 
4. WebMD. Repaglinide oral: Uses, side effects, interactions, pictures, warningsand dosing [Internet]. New York (NY): WebMD LLC; [cited 0.0.3.55 Jul 5]. Available from. 
5. Drugs.com. Repaglinide Monograph [Internet]. Auckland (NZ): Data pharm; [cited 0.0.3.55 Jul 5]. Available from. 
6. Bailey CJ. voglibose: effects on micro and macrovascular complications in type 2 diabetes. Br J Diabetes Vasc Dis. 2008;8(3):121–7. Available from. 
7. Drugs.com. Voglibose [Internet]. Drugs.com International. [cited 2025 Aug 14]. Available from. 
8. DrugBank Online. Voglibose [Internet]. Edmonton (AB): DrugBank; [cited 2025 Aug 14]. Available from. 
9. Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 10th ed. Philadelphia: Elsevier; 2017. Chapter 25, The Endocrine System [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); [cited 2025 Aug 14]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.