Category- Allopathy
Medicine Highlights
| Uses | 1. To treat Idiopathic Pulmonary Fibrosis (IPF) (a disease where lung tissue becomes stiff) 2. To treat Systemic Sclerosis-associated Interstitial Lung Disease (autoimmune disease-causing lungs to become stiff).) 3. To treat chronic fibrosing interstitial lung diseases (ILDs) with progressive phenotype (a group of lung diseases where scar tissue builds up over time, making it harder to breathe) |
| Common Side Effects | 1. Diarrhea 2. Nausea 3. Vomiting 4. Stomach pain 5. Loss of appetite 6. Weight loss 7. Headache 8. Fatigue |
| Additional Information | 1. Take it exactly as prescribed by your doctor. 2. Avoid smoking, as it can reduce the medicine’s effect. 3. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | This medication is meant to be taken orally |
Nintedanib Uses
Nintedanib belongs to tyrosine kinase inhibitor, that helps slow down the hardening or stiffening of the lungs and makes breathing easier in the following lung diseases:
- Idiopathic Pulmonary Fibrosis (IPF)
- Systemic Sclerosis-Associated Interstitial Lung Disease
- Chronic fibrosing interstitial lung diseases
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Nintedanib side effects
More Common
- Headache
- Nausea or vomiting
- Stomach upset
- Dizziness
- Cough
Less Common
- Liver problems (yellowing of eyes/skin, dark urine)
- Bleeding (nosebleeds, easy bruising)
- Heart problems
- Severe allergic reactions (rash, swelling, trouble breathing)
How Nintedanib works
Nintedanib works by blocking certain proteins in the body that cause lung tissue to become thick and stiff. By slowing down this scarring (fibrosis), it helps keep the lungs more flexible and improves breathing. This action does not cure the disease but slows its progression, helping patients maintain better lung function for longer.
Safety Measures and Warning
Allergy Warning
This medication may cause serious allergic reactions like rash, swelling, or trouble breathing. Inform your doctor in case of any allergic reaction
Liver problems
This medication is processed in the liver and may worsen liver damage. Always communicate with your doctor regarding your medical conditions
Bleeding disorders
Nintedanib can increase bleeding risk if you are already suffering with bleeding disorders. Always communicate with your doctor regarding your medical conditions
Pregnant or breastfeeding women
Safety information is not well established for pregnant or breastfeeding women. Always talk to your doctor before use.
People planning surgery
This medicine may increase bleeding risk during or after surgery to inform your doctor and surgeon in advance.
Nintedanib Interaction with Food Product
Grapefruit or grapefruit juice should be avoided as they can increase the amount of medicine in your blood and raise the risk of side effects. Alcohol should be limited because it can strain the liver and worsen side effects.
Nintedanib Interaction with Other Medicines
Avoid taking Nintedanib with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Nintedanib Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) / Chemical name
methyl 2-hydroxy-3-[N-[4-[methyl-[2-(4-methylpiperazin-1-yl) acetyl] amino] phenyl]-C-phenylcarbonimidoyl]-1H-indole-6-carboxylate
Intake routine/cycle
Daily dose
Take Nintedanib exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Do not take nintedanib more than 300 mg. Taking too much can increase the risk of side effects such as fast heartbeat, severe headache, or dizziness. If you notice any unusual symptoms or feel unwell after taking the medicine, seek immediate medical attention.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Nintedanib Summary
Nintedanib is a medicine used to slow lung scarring and help maintain lung function in conditions like idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated interstitial lung disease (SSc-ILD), and other chronic fibrosing lung diseases that are getting worse over time. It works by blocking enzymes that cause lung tissue to become stiff, which helps slow disease progression.
Common side effects include diarrhea, nausea, vomiting, stomach pain, loss of appetite, weight loss, headache, and fatigue, while rare side effects may include liver problems, bleeding, heart issues, or severe allergic reactions. It should be used under a doctor’s guidance, especially in people with liver problems, bleeding risks, or during pregnancy.
FAQ’s
What are the uses of Nintedanib?
Nintedanib is used to slow lung scarring and maintain lung function in idiopathic pulmonary fibrosis (IPF), systemic sclerosis-associated interstitial lung disease (SSc-ILD), and other chronic fibrosing lung diseases with progressive worsening.
How does Nintedanib work?
Nintedanib blocks certain enzymes that cause lung scarring, helping to slow lung damage and preserve lung function in fibrotic lung diseases.
What are the side effects of Nintedanib?
Nintedanib can commonly cause diarrhea, nausea, vomiting, stomach pain, loss of appetite, weight loss, headache, and tiredness. Rarely, it may cause serious problems like liver damage (yellowing of eyes or skin, dark urine), unusual bleeding or bruising, heart problems, or severe allergic reactions such as rash, swelling, or trouble breathing.
What is the price of Nintedanib 100 mg tablets?
Nintedanib 100 mg tablets price at one of the online pharmacies like SayaCare is about 540 rupees, at SayaCare we provide test report with each medicine. Also, at SayaCare they provide you with medicines at up to 80% less cost than the market.
Reference
- PubChem. Nintedanib [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Oct 1]. Available from
- Nintedanib Dosage Guide + Max Dose, Adjustments [Internet]. Drugs.com. 2025 [cited 2025 Oct 1]. Available from
- Gole S, Bankole A. Nintedanib [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. Available from
- Nintedanib [Internet]. go.drugbank.com. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.