Remogliflozin 100 mg + Vildagliptin 50 mg

Category- Allopathy

Medicine Highlights

Remogliflozin + Vildagliptin Uses

Remogliflozin 100 mg + vildagliptin 50 mg is an oral combination medicine belonging to the category of antidiabetic drugs and is used to manage type 2 diabetes mellitus.

Remogliflozin + Vildagliptin side effects 

More Common

1. Headache  
2. Cough  
3. Constipation  
4. Excessive sweating  
5. Weakness  
6. Thirst  
7. Dizziness  
8. Increased Urine

Less Common 

1. Hypoglycemia (especially when used with other medications) 
2. Swelling of the face, lips, or eyelids 
3. Heartburn 
4. Liver enzyme elevation 
5. Burning or pain while peeing 
6. Itchy skin 
7. Skin rash 

How Remogliflozin + Vildagliptin works 

Remogliflozin and vildagliptin work by tackling high blood sugar from two angles in type 2 diabetes; remogliflozin blocks SGLT2 channels in the kidneys, allowing excess glucose to exit through urine, while vildagliptin protects pancreatic hormones that help the pancreas release insulin.This dual action controls sugar without weight gain and may even help with slight weight loss.

Safety Measures and Warning 

Pregnancy

Due to a lack of studies on the effects of Remogliflozin and vildagliptin on the fetus, its safety is not clearly established. Therefore, if you are pregnant or planning to conceive, inform your doctor.

Breastfeeding

Small amounts of Remogliflozin and vildagliptin pass into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop vildagliptin.

Kidney and Liver Problems

 Patients suffering from kidney and liver problems are more prone to kidney and liver damage. As the drug is made into a less toxic form in the liver and kidney, consult a doctor before using them.

Remogliflozin + Vildagliptin Interaction with Food Product 

Avoid alcohol and smoking simultaneously, as they may affect the drug’s action and show an effect on blood glucose levels by affecting the liver and pancreas. It can sometimes increase blood sugar levels and sometimes decrease blood sugar levels.

Remogliflozin + Vildagliptin Interaction with Other Medicines  

Avoid taking Remogliflozin + vildagliptin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Remogliflozin + Vildagliptin Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Remogliflozin- 5-Methyl -4-[4-(1-methylethoxy) benzyl] -1-(1-methylethyl) -1H-pyrazol-3-yl 6-O-(ethoxy carbonyl)-β-D-glucopyranoside.

Vildagliptin-(2S)-1-[2-[(3-hydroxyadamantan-1-yl) amino]acetyl] pyrrolidine-2-carbonitrile 

Intake routine/cycle

Daily dose

Take Remogliflozin + Vildagliptin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 30 mg of Remogliflozin and 300 mg of vildagliptin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. Immediately give the patient fruit or glucose-containing liquids and sugary foods to minimize the effects.

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take Remogliflozin + Vildagliptin exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Remogliflozin + Vildagliptin without your doctor’s approval, even if you feel better. 
3. If you forget to take Remogliflozin + Vildagliptin, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Remogliflozin + Vildagliptin Summary 

Remogliflozin and vildagliptin are dual-action tablets for type 2 diabetes, Remogliflozin flushes excess sugar through urine by blocking kidney sugar channels (SGLT2), while vildagliptin boosts insulin release by protecting incretin hormones. Together, they improve blood sugar control, may aid weight loss, and are generally well tolerated. Common side effects include urinary infections, headaches, and sore throat. Food has minimal impact, but staying hydrated and avoiding heavy fatty meals is advised. Taking more than 400 mg of remogliflozin and vildagliptin combination can cause overdosing effects like very low blood sugar, dehydration, frequent urination, muscle pain, swelling, or abnormal lab results. People with severe kidney or liver problems, type 1 diabetes, or women who are pregnant or breastfeeding should avoid this medicine.

FAQ’s

What is the maximum dose of vildagliptin per day?

It is not recommended to take more than 400 mg of vildagliptin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. Immediately give the patient fruit or glucose-containing liquids and sugary foods to minimize the effects. 

What are the side effects of remogliflozin + vildagliptin tablets?

Vildagliptin is a pill taken by people with type 2 diabetes to help keep their blood sugar levels under control. Most people tolerate it well, but some may get common side effect like feeling tired or headaches or have minor stomach issues

What is the mechanism of action of vildagliptin?

Your body is like a classroom, and sugar is homework for your cells. Insulin helps deliver the homework, but in diabetes, some cells stop accepting it, so sugar builds up in the blood. GLP-1 and GIP are helpers that remind cells to take the sugar, but DPP-4 makes them leave too soon. Vildagliptin stops DPP-4, so the helpers stay longer and help the body use sugar better.

What are the uses of vildagliptin?

Vildagliptin is an oral antidiabetic medicine used to treat type 2 diabetes by promoting the insulin production and inhibiting an insulin-killing enzyme known as dipeptidyl peptidase.

Reference 

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Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.