Paroxetine 25 mg (PR)

Category- Allopathy

Medicine Highlights

Paroxetine Summary

Paroxetine is an antidepressant from the SSRI (selective serotonin reuptake inhibitor) family, commonly used to treat depression, anxiety disorders, obsessive compulsive disorder, and panic attacks. It works by increasing serotonin levels in the brain, a chemical that helps stabilize mood and reduce anxiety. Common side effects include nausea, sleepiness, dry mouth, sweating, and sometimes sexual problems. People who are pregnant, planning pregnancy, or taking certain medications (like blood thinners or monoamine oxidase inhibitors) should avoid it or consult their doctor. Alcohol can worsen side effects, so it’s best to avoid drinking while on it. Store paroxetine in a cool, dry place away from sunlight and kids. Always follow your doctor’s instructions, and don’t stop suddenly without medical advice.

Paroxetine Uses 

Paroxetine 25 mg is an oral medicine belonging to the category of selective serotonin reuptake inhibitor antidepressants (SSRIs) and is used for the following indications: 

1. Depression 
2. Obsessive-compulsive disorder (OCD) 
3. Panic disorder 
4. Social anxiety disorder 
5. Anxiety (generalized anxiety disorder) 
6. Posttraumatic stress disorder (PTSD) 
7. Severe symptoms of Premenstrual syndrome 

Paroxetine side effects

More Common

1. Sexual problems 
2. Stomach problems like nausea, vomiting, diarrhea, or constipation 
3. Dry mouth 
4. Trouble sleeping 
5. Nervousness 
6. Sweating 
7. Yawning 
8. Weakness 
9. Headache 
10. Not feeling hungry 
11. Blurry vision 
12. Dizziness 
13. Infection 
14. Sleepiness or tiredness 
15. Shaking 

Less Common

1. Breathing problems or wheezing 
2. Racing heart 
3. Fever or general ill feeling 
4. Swollen lymph nodes 
5. Swelling of the face, lips, mouth, tongue, or throat 
6. Trouble swallowing or throat tightness 
7. Itching, skin rash, or pale red bumps on the skin called hives 
8. Nausea or vomiting 
9. Dizziness, feeling lightheaded, or fainting 
10. Stomach cramps 
11. Joint pain 
12. Suicidal thoughts 
13. Increased mood 
14. Arrhythmia 

How paroxetine works 

Paroxetine works by boosting serotonin, a natural mood-balancing chemical that’s often low in people with depression, anxiety, obsessive compulsive disorder, or panic attacks. Imagine the brain like a traffic system without enough serotonin; signals get jammed, causing emotional distress. Paroxetine helps clear the congestion, letting calming signals flow smoothly. Over time, it helps restore mental balance, so daily life feels less overwhelming and more manageable. 

Safety Measures and Warning 

Past mental health issues

Patients having previous mental health problems can experience potential psychiatric symptoms, so meet with a doctor before using them. 

Pregnancy

Paroxetine can pass through the placenta and can cause abnormalities or deformations in the baby, like improper development of heart, so it is recommended to consult a doctor before using it. 

Breastfeeding

Paroxetine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it. 

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, so consult a doctor before using them.

Paroxetine Interaction with Food Product

Alcohol and smoking can simultaneously cause an increase or decrease in drug action; also, they may cause severe drowsiness and sedation as they act on the brain directly. 

Paroxetine Interaction with Other Medicines

Avoid taking paroxetine 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Paroxetine Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/Chemical name

(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy) methyl]-4-(4-fluorophenyl) piperidine

Intake routine/cycle

Daily dose

Take paroxetine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 300 mg of paroxetine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, low BP, unconsciousness, respiratory depression, arrhythmia, hallucinations, and serotonin syndrome. 

Storage

1. Store the medicine at room temperature.
2. Keep away from sunlight and moisture.
3. Keep out of reach of children.

Directions for use 

1. If you forget to take paroxetine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take paroxetine exactly as prescribed by your doctor, at the same time each day. 
3. Do not stop taking paroxetine without your doctor’s approval, even if you feel better. 

FAQ’s

What are the side effects of paroxetine tablets? 

Common side effects include nausea, dizziness, dry mouth, insomnia, and sexual dysfunction. Paroxetine may interact with other serotonergic drugs, mono amino oxidase inhibitors, and certain antipsychotics, increasing the risk of serotonin syndrome.

What is paroxetine used for? 

Paroxetine is commonly prescribed for major depressive disorder, panic disorder, obsessive-compulsive disorder, post -traumatic stress disorder. 

What is Paroxetine lowest dose?

The lowest dose of paroxetine to get an optimum effect with minimal side effects is 10 mg.

What is paroxetine mechanism of action? 

Paroxetine is an antidepressant that helps improve your mood by balancing a chemical called serotonin in your brain. Serotonin acts like a natural “feel-good” messenger, helping you feel calm, relaxed, and emotionally steady. In people with depression or anxiety, serotonin levels may be too low or not working properly.

Reference

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 43815, Paroxetine [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 1]. Available from. 
2. Mayo Foundation for Medical Education and Research. Paroxetine (Oral Route) Description and Brand Names [Internet]. Rochester (MN): Mayo Clinic; c2023 [cited 2025 Jul 1]. Available from. 
3. DrugBank Online. Paroxetine: DB00715 [Internet]. Edmonton (AB): Canadian Institute for Health Informatics; [cited 2025 Jul 1]. Available from. 
4. WebMD. Paroxetine Oral: Uses, Side Effects, Interactions and More [Internet]. New York (NY): WebMD, LLC; [cited 2025 Jul 1]. Available from. 
5. Drugs.com. Paroxetine: Uses, Dosage, Side Effects, Interactions [Internet]. Auckland (NZ): Datapharm; [cited 2025 Jul 1]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.