Category- Allopathy
Medicine Highlights
| Uses | 1. To treat asthma 2. To treat chronic bronchitis 3. To treat COPD (Chronic Obstructive Pulmonary Disease) 4. Relieves symptoms of allergic rhinitis such as sneezing, itching, runny nose, and nasal congestion |
| Common Side Effects | 1. Headache 2. Nausea, vomiting 3. Stomach pain, indigestion 4. Diarrhea 5. Dizziness 6. Insomnia (trouble sleeping) 7. Irritability or mood changes 8. Cough, sore throat |
| Additional Information | 1. Take it exactly as prescribed by your doctor. 2. Avoid smoking, as it can reduce the medicine’s effect. 3. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | This medicine is meant to be taken orally |
Doxofylline + Montelukast Uses
Doxofylline + Montelukast are a combination medicine used to help open the airways and reduce inflammation in the lungs in the following conditions:
- Asthma
- Chronic bronchitis
- COPD (Chronic Obstructive Pulmonary Disease)
- Allergic rhinitis symptoms such as sneezing, itching, runny nose, and nasal congestion
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Doxofylline + Montelukast side effects
More Common
- Headache
- Nausea or vomiting
- Stomach upset
- Dizziness
- Cough
- Mild sleep problems or restlessness
Less Common
- Allergic reactions
- Mood/behavior changes
- Palpitations
- Irregular heartbeat
- Seizures
- Liver problems
How Doxofylline + Montelukast works
Doxofylline and Montelukast work together to make breathing easier. Doxofylline relaxes the muscles of the airways, so the tubes carrying air to the lungs stay open and reduce wheezing or tightness. Montelukast blocks certain natural substances (called leukotrienes) that cause swelling, mucus, and allergies in the lungs. By combining these actions, this medicine helps control asthma, allergies, and breathing problems.
Safety Measures and Warning
Allergy Warning
It can cause serious allergic reactions like rash, swelling, or trouble breathing. Always tell your doctor about any past drug allergies before starting this medicine.
Heart Problems
Doxofylline can sometimes disturb heart rhythm and worsen heart conditions. Consult your doctor before using.
Liver Disease
Both medicines are broken down in the liver, and weak liver function can cause harmful effects. Your doctor may adjust the dose or avoid this combination if your liver is affected.
Seizures or Epilepsy
Doxofylline may trigger fits in some patients inform your doctor if you have this history.
Children
The dose of this medicine may be too strong and unsafe; your doctor will prescribe a lower dose if needed.
Pregnant or Breastfeeding Women
The safety of this combination during pregnancy and breastfeeding is not fully known. Always talk to your doctor before taking this medicine.
Doxofylline + Montelukast Interaction with Food Product
It’s best to avoid very large or heavy meals right before taking the medicine, as it may slightly reduce absorption. Always follow your doctor’s instructions and check with them if you are taking other medicines or herbal supplements.
Doxofylline + Montelukast Interaction with Other Medicines
Avoid taking Doxofylline + Montelukast with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Doxofylline + Montelukast Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) / Chemical name
Doxofylline: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione.
Montelukast: sodium 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate
Intake routine/cycle
Daily dose
Take Doxofylline + Montelukast exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Do not take more than the prescribed dose of Doxofylline + Montelukast. Taking too much can increase the risk of side effects such as fast heartbeat, severe headache, or dizziness. If you notice any unusual symptoms or feel unwell after taking the medicine, seek immediate medical attention.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Doxofylline + Montelukast Summary
Doxofylline and Montelukast work together to help people with breathing problems like asthma, COPD, and allergy-related respiratory issues. Doxofylline relaxes the airway muscles, making it easier to breathe, while Montelukast blocks substances that cause swelling and allergy symptoms in the lungs. This combination helps reduce wheezing, shortness of breath, cough, and allergic reactions.
Common side effects include headache, nausea, stomach pain, dizziness, and trouble sleeping, while rare side effects may involve allergic reactions, mood changes, irregular heartbeat, seizures, or liver problems. It should be used with caution in people with heart or liver problems, seizures, or allergies, and always under a doctor’s guidance.
FAQ’s
What are the uses of Doxofylline + Montelukast tablet?
They are used to prevent and treat asthma, chronic obstructive pulmonary disease (COPD), wheezing, shortness of breath, and allergy-related respiratory problems.
What are the side effects of Doxofylline + Montelukast tablets
These tablets can commonly cause headache, nausea, vomiting, stomach pain, indigestion, diarrhea, dizziness, trouble sleeping, irritability, cough, or sore throat. Rarely, they may lead to serious effects like allergic reactions, mood or behavior changes, irregular heartbeat, seizures, or liver problems.
What is the price of Doxofylline + Montelukast tablets?
Doxofylline + Montelukast tablets price at one of the online pharmacies like SayaCare is about 105 rupees, at SayaCare we provide test report with each medicine. Also, at SayaCare we provide you medicines with up to 80% less cost than the market.
Does Montelukast help you sleep?
No, Montelukast does not help with sleep. In fact, some people may experience insomnia or trouble sleeping as a side effect.
What drug class does Montelukast belong to?
Montelukast belongs to the class called leukotriene receptor antagonists (LTRAs), which work by blocking substances in the body that cause airway swelling, tightening, and allergy symptoms.
Reference
- ApolloPharmacy [Internet]. Apollopharmacy.in. 2019 [cited 2025 Oct 1]. Available from
- Doxofylline [Internet]. go.drugbank.com. Available from
- PubChem. Doxofylline [Internet]. Nih.gov. PubChem; 2024. Available from
- PubChem. Montelukast [Internet]. pubchem.ncbi.nlm.nih.gov. 2024. Available from
- Drugbank. Montelukast [Internet]. go.drugbank.com. 2025. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.