Lamotrigine 25 mg

Category- Allopathy

Medicine Highlights

Lamotrigine Summary 

Lamotrigine 25 mg is an oral anticonvulsant and mood stabilizer, commonly prescribed for epilepsy and also for off-label indications like bipolar disorder. It works by blocking sodium channels and reducing glutamate release, as glutamate is responsible for seizures. Common side effects include dizziness, headache, nausea, blurred vision, vomiting, and skin rash. High-protein meals will slightly alter its action, and caution is advised with grapefruit, caffeine, star fruit, and herbal supplements like ginseng and garcinia cambogia due to potential metabolic effects that reduce the drug’s action. 

Lamotrigine Uses 

Lamotrigine 25 mg is an oral medicine belonging to the category of anticonvulsants and is used for the following indications:

1. Seizures 
2. Bipolar disorder

Lamotrigine side effects 

More Common  

1. Blurred vision 
2. Changes in vision 
3. Chest pain, discomfort, or tightness 
4. Clumsiness or unsteadiness 
5. Decreased urine output 
6. Dilated neck veins 
7. Double vision 
8. Irregular breathing 
9. Irregular heartbeat 
10. Nausea 
11. Pain or discomfort in the arms, jaw, back, or neck 
12. Poor coordination 
13. Skin rash 
14. Sweating 
15. Swelling of the face, fingers, feet, or lower legs 
16. Trouble breathing 
17. Unusual tiredness or weakness 
18. Vomiting 
19. Weight gain 

Less Common

1. Anxiety 
2. Chest pain 
3. Confusion 
4. Continuous, uncontrolled back-and-forth or rolling eye movements 
5. Depression 
6. Increase in seizures 
7. Infection 
8. Irritability 
9. Blistering, peeling, or loosening of the skin 
10. Chills 
11. Cough 
12. Dark urine 
13. Diarrhea 
14. Fever 
15. General feeling of discomfort or illness 
16. Headache 
17. Itching 
18. Joint pain 
19. Loss of appetite 

How Lamotrigine Works

Lamotrigine works by calming the extra electrical activity in the brain that causes seizures, which is like a dam controlling the rush of water in a river. In epilepsy, the nerves send too many signals too fast, making the body shake or freeze. Lamotrigine helps slow down this signal flow, bringing balance and keeping the mind steady. 

Safety Measures and Warning 

Past mental health issues

Lamotrigine directly acts on the brain and causes different effects like sedation, drowsiness, and suicidal thoughts. Inform the doctor about your past mental health issues before taking the medication. 

Pregnancy

Lamotrigine is the most used antiepileptic drug in pregnant women. But there are no studies supporting it being safer in any research. Get a recommendation from the doctor before using it. 

Breastfeeding

Lamotrigine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it. 

Kidney and Liver Problems

There are few cases suggesting that acute kidney disease and acute liver disease patients are more prone to liver and kidney damage due to some enzymes released in these stages interacting with the drug. So, consult a doctor if you have these problems.

Lamotrigine Interaction with Food Product

Avoid alcohol and smoking simultaneously, as together with lamotrigine, this can cause some serious side effects like confusion, hallucinations, drowsiness, and sedation. So, try to avoid alcohol consumption and smoking. Go to the hospital if you face any problems.

Lamotrigine Interaction with Other Medicines

Avoid taking Lamotrigine 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Lamotrigine Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/Chemical name

2-[2-(4-dibenzo [1,4] thiazepin-11-yl-1-piperazinyl) ethoxy] ethanol

Intake routine/cycle

Daily dose

Take Lamotrigine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage

Overdose

It is not recommended to take more than 500 mg of lamotrigine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, high blood pressure, hallucinations, confusion, and slurred speech. Immediately seek medical care in case of any overdose symptoms. 

Storage

1. Store the medicine at room temperature.
2. Keep away from sunlight and moisture.
3. Keep out of reach of children.

Directions of use 

1. If you forget to take lamotrigine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take lamotrigine exactly as prescribed by your doctor, at the same time each day. 
3. Do not stop taking lamotrigine without your doctor’s approval, even if you feel better. 

FAQ’s

What are lamotrigine tablets used for? 

Lamotrigine is a medicine that belongs to the class of anticonvulsants used to control seizures and to treat bipolar disorder. 

What are the indications for lamotrigine?

Lamotrigine belongs to the category of anticonvulsants and is used to control seizures and bipolar disorder.

What are the side effects of lamotrigine?

Common side effects of lamotrigine include dizziness, headaches, nausea, blurred vision, vomiting, and skin rash. 

What is the overdose amount of lamotrigine?

It is not recommended to take more than 500 mg of Lamotrigine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, high blood pressure, hallucinations, confusion, and slurred speech. Immediately seek medical care in case of any overdose symptoms. 

Reference

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2. National Center for Biotechnology Information. PubChem Compound Summary for CID 3878, Lamotrigine [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 9]. Available from. 
3. Mayo Clinic Staff. Lamotrigine (Oral Route) Description and Brand Names [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; 2023 [cited 2025 Jul 9]. Available from. 
4. WebMD. Lamotrigine Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing [Internet]. [cited 2025 Jul 9]. Available from. 
5. Drugs.com. Lamotrigine: Uses, Dosage, Side Effects, Warnings [Internet]. [cited 2025 Jul 9]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.