Vildagliptin 50 mg + Metformin 500 mg

Category- Allopathy

Medicine Highlights

Vildagliptin + Metformin Uses

Vildagliptin 50 mg + Metformin 500 mg is an oral medicine belonging to the category of antidiabetic drugs and is used for the management of type 2 Diabetes mellitus.

Vildagliptin + Metformin side effects 

More Common  

1. Headache 
2. Cough 
3. Constipation 
4. Excessive sweating 
5. Weakness 
6. Unusual muscle pain 
7. Feeling cold 
8. Trouble breathing 
9. Feeling dizzy, light-headed, tired, or very weak 
10. Stomach pain, vomiting 
11. Slow or irregular heart rate. 

Less Common 

1. Swelling of the face, lips, or eyelids 
2. Heartburn 
3. Liver enzyme elevation 
4. Low blood sugar 
5. Nausea, upset stomach 
6. Diarrhea 

How Vildagliptin + Metformin works 

In type 2 diabetes, the body either doesn’t produce enough insulin or doesn’t respond to it properly, leading to high blood sugar levels. Metformin works mainly in the liver: it reduces how much glucose the liver produces and helps muscles use insulin more effectively. Vildagliptin belongs to a group called DPP-4 inhibitors. It stops the breakdown of hormones like GLP-1 and GIP, which signal the pancreas to release insulin after meals and reduce glucagon, the hormone that raises blood sugar.

Safety Measures and Warning 

Pregnancy

Due to a lack of studies on the effects of vildagliptin and metformin on the fetus during pregnancy, its safety is not clearly established. Therefore, if you are pregnant or planning to conceive, inform your doctor.

Breastfeeding

Small amounts of vildagliptin and metformin pass into breast milk. Tell your doctor if you are breastfeeding or plan to breastfeed, and they will advise you whether to stop breastfeeding or stop the medicine.

Kidney and Liver Problems

Vildagliptin and metformin are cleared through the liver and kidneys, so in patients with existing kidney and liver problems, these organs may get strained or damaged. So, inform the doctor before using the medicine

Vildagliptin + Metformin Interaction with Food Product 

Alcohol and smoking can simultaneously affect the drug’s action and show an effect on blood glucose levels by affecting the liver and pancreas. It can sometimes increase blood sugar levels and sometimes decrease blood sugar levels.

Vildagliptin + Metformin Interaction with Other Medicines  

Avoid taking Vildagliptin and Metformin with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Vildagliptin + Metformin Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Vildagliptin-(2S)-1-[2-[(3-hydroxyadamantan-1-yl) amino]acetyl]pyrrolidine-2-carbonitrile

Metformin-N, N-dimethylimidodicarbonimidic diamide

Intake routine/cycle

Daily dose

Take vildagliptin and metformin exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

: If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 400 mg of vildagliptin and 2550 mg of metformin per day, as it may cause severe overdosing effects like extreme dizziness, confusion, low blood pressure, liver damage, low blood sugar levels, swelling, muscle damage, and seizures. If overdosing effects remain unchanged, supply the patient with fruit or glucose liquids and sugary foods to minimize the effects, and meet the doctor.

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take Vildagliptin and metformin exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Vildagliptin and metformin without your doctor’s approval, even if you feel better. 
3. If you forget to take Vildagliptin and metformin, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Vildagliptin + Metformin Summary 

The vildagliptin + metformin combination is a medicine used to manage type 2 diabetes when diet and exercise alone aren’t enough. It works in two ways: vildagliptin helps the body release more insulin and reduce excess sugar made by the liver, while metformin lowers sugar production and improves how the body uses insulin. Together, they help control blood sugar levels without causing too many lows. Common side effects include stomach upset, headache, dizziness, and tiredness, which are usually mild and manageable. It’s not suitable for people with serious kidney, liver, or heart problems, or during pregnancy. Alcohol should be avoided while taking it, as it can increase the risk of serious complications like lactic acidosis. To reduce stomach issues, it’s best taken with meals.

FAQ’s

What is the vildagliptin dose with metformin?

Vildagliptin and metformin are one of the most effective combinations for the treatment of diabetes 2, and the commonly used dose of vildagliptin is 50 mg in different combinations of metformin.

What are the uses of vildagliptin and metformin tablets?

Vildagliptin and metformin are a combination medicine used to manage type 2 diabetes when diet and exercise alone aren’t enough. It works in two ways: vildagliptin helps the body release more insulin and reduce excess sugar made by the liver, while metformin lowers sugar production and improves how the body uses insulin

What is the mode of action of Vildagliptin and Metformin?

In type 2 diabetes, the body struggles with insulin production or response, causing high blood sugar. Metformin lowers liver glucose output and improves insulin use in muscles. Vildagliptin boosts gut hormones (GLP-1, GIP) that enhance insulin release and suppress glucagon after meals. Together, they support smoother post-meal sugar control with less risk of hypoglycemia.

What are vildagliptin and metformin brands in India?

Although there are various brand names for the vildagliptin and metformin combination, like Galvus Met, Jalra-M, Vysov-M, and Dasvida-M etc. Many of the brands fail to address the quality standards set by Central Drug Control Standards Organization (CDSCO), and this is where Saya care steps in and provides the quality report of every medicine with 80% lesser price than the marketed products.

Reference 

1. Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing; 2024 Jan–. Available from. 
2. Drug Bank. Metformin [Internet]. Edmonton (AB): Drug Bank; [cited 2025 Jul 18]. Available from. 
3. WebMD. Metformin oral [Internet]. New York (NY): WebMD LLC; ©1996–2025 [cited 2025 Jul 18]. Available from. 
4. Drugs.com. Metformin [Internet]. ©1996–2025 [cited 2025 Jul 18]. Available from. 
5. European Medicines Agency. Galvus: EPAR – Product Information. EMA; [cited 2025 Jul 18]. Available from. 
6. Medicover Hospitals. Vildagliptin: Uses, Dosage, Side Effects, Price. Medicover Hospitals; [cited 2025 Jul 18]. Available from. 
7. DrugBank. Vildagliptin (DB04876). DrugBank Online; [cited 2025 Jul 18]. Available from. 
8. Gallwitz B. Clinical Use of DPP-4 Inhibitors. Frontiers in Diabetes. 2009;19:137–152. [cited 2025 Jul 18]. Available from. 
9. Drugs.com. Galvus 50mg tablets-Summary of Product Characteristics (SPC). Drugs.com UK; [cited 2025 Jul 18]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.