Pregabalin 75 mg + Nortriptyline 10 mg

Category- Allopathy

Medicine Highlights

Pregabalin + Nortriptyline Summary

Pregabalin and nortriptyline is a combination medicine used to treat chronic nerve pain, like the kind caused by diabetes, sciatica, or shingles. Pregabalin helps calm overactive nerves that keep sending pain signals, and nortriptyline helps boost certain brain chemicals that reduce the feeling of pain and improve mood and sleep. Together, they give better relief than either one alone. Common side effects include feeling sleepy or dizzy, dry mouth, blurry vision, constipation, weight gain, and sometimes swelling in the feet. People with serious heart, kidney, or liver problems, or who’ve had allergic reactions to these medicines, should avoid this medicine. It’s not safe to use it during pregnancy or breastfeeding without a doctor’s advice. Drinking alcohol or taking other sleep-inducing medicines while on this can make side effects worse. Always follow the doctor’s instructions and never stop taking this medicine suddenly.

Pregabalin + Nortriptyline Uses 

Pregabalin 75 mg and nortriptyline 10 mg are oral combination medicines belonging to the category of anticonvulsant and vitamin supplements and are used for the following indications: 

1. Nerve pain caused after herpes 
2. Diabetic nerve pains 
3. Seizures 
4. Musculoskeletal pain (Fibromyalgia) 
5. Sciatic Pain 

Pregabalin + Nortriptyline side effects

More Common

1. Dizziness  
2. Sleepiness  
3. Headache  
4. Tiredness  
5. Fluid retention  
6. Nausea  
7. Blurred vision  
8. Dry mouth  
9. Weight gain 
10. Constipation 
11. Inability to empty your bladder 
12. Dry mouth 
13. Drowsiness 
14. Dizziness 
15. Confusion 

Less Common

1. Breathing problems or wheezing 
2. Racing heart 
3. Fever or general ill feeling 
4. Swollen lymph nodes 
5. Swelling of the face, lips, mouth, tongue, or throat 
6. Trouble swallowing or throat tightness 
7. Itching, skin rash, or pale red bumps on the skin called hives 
8. Nausea or vomiting 
9. Dizziness, feeling lightheaded, or fainting 
10. Stomach cramps 
11. Joint pain 
12. Suicidal thoughts 
13. Hallucinations 
14. Dizziness or confusion 
15. Blurry vision 
16. Slurred speech 
17. Sweating 
18. Feeling shakiness 

How Pregabalin + Nortriptyline works 

Pregabalin and nortriptyline work together to ease nerve pain, especially in conditions like diabetic neuropathy, sciatica, or post-shingles pain, where damaged nerves keep sending pain signals even when there’s no injury. Imagine your nerves as telephone wires; when they’re fired, they send wrong messages, like pain, to your brain. Pregabalin acts like a signal blocker; it attaches to special switches (calcium channels) on the nerves and stops them from shouting pain messages. Meanwhile, nortriptyline works like a mood lifter and pain filter; it boosts certain brain chemicals (serotonin and noradrenaline) that help calm the brain’s response to pain and improve sleep and mood. Together, they don’t just silence the faulty wires; they also help your brain feel more balanced and less overwhelmed by pain. This combo is especially helpful when pain affects sleep, emotions, and daily life, giving people a chance to feel normal again.

Safety Measures and Warning 

Past Mental Health Issues

Pregabalin and nortriptyline directly act on the brain and cause different effects like sedation, drowsiness, and suicidal thoughts. inform the doctor about your past mental health issues before using it.

Pregnancy

We don’t know if pregabalin or nortriptyline harm the baby in humans, but animal studies show pregabalin can affect the baby’s growth. It is advised to get a recommendation from the doctor before using it.

Breastfeeding

Pregabalin and nortriptyline pass into breast milk; this combination can cause toxicity in a fetus, so tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop it.

Kidney and Liver Problems

Pregabalin and nortriptyline are known to be safe for use in liver and kidney disease patients. Pregabalin may cause serious liver damage and kidney failure sometimes in patients with serious liver and kidney problems. Consult a doctor before using them.

Pregabalin + Nortriptyline Interaction with Food Product

Avoid alcohol and smoking simultaneously, as together with amitriptyline, this can cause some serious side effects like confusion, hallucinations, drowsiness, and sedation. So, try to avoid alcohol consumption and smoking. Go to the hospital if you face any problems.

Pregabalin + Nortriptyline Interaction with Other Medicines

Avoid taking pregabalin 75 mg + nortriptyline 10 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Pregabalin + Nortriptyline Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/Chemical name

3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine. 

3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropan-1-amine 

Intake routine/cycle

Daily dose

Take pregabalin and nortriptyline exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage

Overdose

It is not recommended to take more than 600 mg of pregabalin and 150 mg of nortriptyline per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and provide the patient sufficient care in terms of overdose and unconscious situations.

Storage

1. Store the medicine at room temperature.
2. Keep away from sunlight and moisture.
3. Keep out of reach of children.

Directions for use 

1. If you forget to take pregabalin and nortriptyline, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take pregabalin and nortriptyline exactly as prescribed by your doctor, at the same time each day. 
3. Do not stop taking pregabalin and nortriptyline without your doctor’s approval, even if you feel better. 

FAQ’s

What are the pregabalin and nortriptyline combination used for? 

Pregabalin and nortriptyline is a combination medicine often used for nerve pain, such as pain from diabetes, sciatica, or after shingles. Pregabalin helps by calming down the nerves that are sending pain signals, and nortriptyline (a type of vitamin B12) helps fix damaged nerves.

What are pregabalin and nortriptyline medicine side effects?  

Some common side effects of pregabalin and nortriptyline include feeling sleepy or dizzy, blurred vision, dry mouth, weight gain, or swelling in hands and feet.

What is the maximum pregabalin-nortriptyline dosage to be taken per day? 

Don’t take more than 600 mg of pregabalin and 150 mg of nortriptyline per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and provide the patient sufficient care.

What are pregabalin and nortriptyline brands in India?

Pregabalin and nortriptyline have different brand names that are endorsed by marketing companies, but the salt name remains the same. Many of the brands fail to pass the CDSCO standard quality test, and it’s the time when Saya Care steps in, and we provide the medicine with a quality test report.

Reference

1. WebMD. Lyrica (Pregabalin) oral details. Available from.  
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4. National Center for Biotechnology Information. PubChem Compound Summary for CID 4446, Nortriptyline [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 9]. Available from. 
5. Shulman DI, Palmert MR, Kemp SF. Adolescent Endocrinology [Internet]. In: Kliegman RM, St Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, editors. Nelson Textbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020 [cited 2025 Jul 9]. Available from. 
6. Drugs.com. Nortriptyline [Internet]. [cited 2025 Jul 9]. Available from. 
7. WebMD. Nortriptyline oral: Uses, side effects, interactions, pictures, warnings [Internet]. [cited 2025 Jul 9]. Available from. 
8. Drug Bank Online. Nortriptyline [Internet]. Ottawa (ON): Canadian Institutes of Health Research; [cited 2025 Jul 9]. Available from. 
9. Kumar A, Sharma S, Wadhwa R, Singh G, Kumar R. Randomized study to compare the effect of pregabalin with fixed‑drug combination of pregabalin and nortriptyline in the patients of postherpetic neuralgia. Indian J Pain. 2018;32(2):111‑6. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.