Acebrophylline (sr) 200 mg + Montelukast 10mg

Category- Allopathy

Medicine Highlights

Acebrophylline + Montelukast Uses 

Acebrophylline + Montelukast rota caps are a combination medicine used to help open the airways and reduce inflammation in the lungs in the following conditions: 

1. Asthma  
2. Chronic bronchitis  
3. COPD (Chronic Obstructive Pulmonary Disease) 

Directions for use

1. Check the label for directions before use.  
2. Place the capsule at the base of rotahaler, not in the mouthpiece.  
3. Twist the mouthpiece completely until your hear a click and breathe in deeply through the mouthpiece. 
4. Rotacaps must not be swallowed. 

Acebrophylline + Montelukast side effects 

More Common  

1. Headache 
2. Nausea or vomiting 
3. Stomach upset 
4. Dizziness 
5. Cough 
6. Mild sleep problems or restlessness 

Less Common

1. Severe allergic reactions (rash, swelling, difficulty breathing) 
2. Fast or irregular heartbeat 
3. Severe dizziness or fainting 
4. Mood changes (anxiety, agitation)  

How Acebrophylline + Montelukast works 

Acebrophylline relaxes the muscles around your airways and helps clear mucus, making it easier to breathe. Montelukast reduces swelling and inflammation caused by allergies or asthma triggers. Together, they help open the airways, reduce wheezing, coughing, and shortness of breath, and prevent asthma or COPD flare-ups. 

Safety Measures and Warning 

Heart problems

Acebrophylline may increase heart rate or cause irregular heartbeat check with your doctor before taking it. 

High blood pressure

The medicine may make your blood pressure worse talk to your doctor for guidance.

Kidney and Liver Problems

The medicine may not be processed properly, increasing side effects doctor advice is important. 

Allergic Reactions or Hypersensitivity

People allergic to Acebrophylline, Montelukast, or any ingredients of this medication are not recommended to take this medicine as it can cause serious allergic reactions like rash, swelling, or trouble breathing always ask your doctor first. 

Pregnant or breastfeeding women

The medicine should only be taken if clearly needed always get your doctor’s approval. 

Acebrophylline + Montelukast Interaction with Food Product

There are no major food restrictions. However, it is best to avoid very large or heavy meals just before taking the medicine, as they may slightly reduce its absorption. Always follow your doctor’s instructions and consult them if you are taking other medicines or herbal supplements. 

Acebrophylline + Montelukast Interaction with Other Medicines

Avoid taking acebrophylline + montelukast with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Acebrophylline + Montelukast Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Acebrophylline: 4-[(2-amino-3,5-dibromobenzyl) amino] cyclohexan-1-ol 2-(1,3-dimethyl-2,6-dioxopurin-7-yl) acetate 

Montelukast: sodium 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl) ethenyl] phenyl]-3-[2-(2-hydroxypropan-2-yl) phenyl] propyl] sulfonylmethyl] cyclopropyl] acetate 

Intake routine/cycle

Daily dose

Take Acebrophylline + Montelukast exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

It is not recommended to take more than the prescribed dose of Acebrophylline + Montelukast rota caps. Taking too much can increase the risk of side effects such as fast heartbeat, severe headache, or dizziness. If you notice any unusual symptoms or feel unwell after taking the medicine, seek immediate medical attention.  

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Acebrophylline + Montelukast Summary 

Acebrophylline + Montelukast is a combination medicine used to help people with asthma, chronic bronchitis, and COPD breathe more easily. Acebrophylline relaxes the muscles around the airways and helps clear mucus, while Montelukast reduces swelling and inflammation caused by allergies or asthma triggers. Together, they help open the airways, reduce wheezing, coughing, chest tightness, and shortness of breath, and prevent asthma or COPD flare-ups.  

Common side effects may include headache, nausea, stomach upset, dizziness, cough, or mild sleep problems. Rare but serious side effects include allergic reactions, fast heartbeat, severe dizziness, or mood changes. The medicine should be taken exactly as prescribed, after meals if possible, and patients should consult their doctor before use, especially if they have heart, liver, or kidney problems, are pregnant, or are taking other medications. 

FAQ’s

What are the side effects of acebrophylline? 

Acebrophylline side effects include nausea, vomiting, diarrhea, constipation, heartburn, loss of appetite, rash, itching, drowsiness, red spots or bumps, breathing problems, increased white blood cell count, abdominal discomfort, abdominal distension, esophageal bleeding, nasal inflammation, dizziness 

What are the uses of acebrophylline? 

Acebrophylline is an oral bronchodilator used to treat COPD (long-term breathing problem), bronchial asthma (swollen narrow airways), chronic bronchitis (long-lasting wet cough), emphysema (damaged lung air sacs), and breathing issues due to allergies or inflammation. 

What is the mechanism of action of acebrophylline ? 

Acebrophylline, which works by relaxing the airway muscles and widening the bronchial passages in the lungs. It also reduces the thickness of mucus, making it easier to expel through coughing. This helps improve airflow and makes breathing more comfortable. 

What are the uses of montelukast? 

Montelukast is used to prevent and control asthma symptoms, reduce allergy-related breathing problems, and help prevent wheezing, coughing, and shortness of breath caused by asthma or allergies.  

How does montelukast work? 

Montelukast blocks chemicals called leukotrienes in the body that cause swelling and tightening of the airways. By doing this, it helps open the airways, reduces inflammation, and prevents asthma attacks or allergy-related breathing problems. 

What drug class does montelukast belong to? 

Montelukast belongs to the class called leukotriene receptor antagonists (LTRAs), which work by blocking substances in the body that cause airway swelling, tightening, and allergy symptoms. 

Reference 

1. PubChem. Montelukast [Internet]. pubchem.ncbi.nlm.nih.gov. 2024. Available from 
2. Drugbank. Montelukast [Internet]. go.drugbank.com. 2025. Available from 
3. Acebrophylline (sr)200 mg , montelukast 10mg tablet: Uses, Side Effects, Price | Generic | SayaCare [Internet]. Sayacare.in. 2025 [cited 2025 Sep 24]. Available from  
4. ApolloPharmacy [Internet]. Apollopharmacy.in. 2019 [cited 2025 Sep 24]. Available from 

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.