Clobazam 5 mg

Category- Allopathy

Medicine Highlights

Clobazam Uses

Clobazam 5 mg is an oral medicine belonging to the category of benzodiazepines and is used for the following indications:

1. Acute anxiety 
2. Seizures (Lennox gastaut and focal) 

Clobazam side effects 

More Common  

1. Difficulty with swallowing 
2. Fever 
3. Shakiness and unsteady walk 
4. Unsteadiness, trembling, or other problems with muscle control or coordination 

Less Common 

1. Change in speech pattern 
2. Restlessness 
3. Slurred speech 
4. Trouble sitting still 
5. Trouble speaking. 

How Clobazam works 

Clobazam boosts the calming effects of gamma‑aminobutyric acid (GABA) to quiet overactive brain signals and reduce seizures, like turning down a noisy brain’s volume. For patients, it’s a quiet helper that brings steadiness when the brain feels stormy.

Safety Measures and Warning 

Pregnancy

There are no well-researched human studies on the effect of clobazam, but there are animal studies clearly indicating that it affects the fetus’s development directly. So, take a recommendation from the doctor before using it.

Breastfeeding

Clobazam can pass into breast milk and may rarely lower your baby’s blood pressure or cause tiredness. Safer options like enalapril are preferred; talk to your doctor before continuing.

Clobazam Interaction with Food Product 

Avoid consuming alcohol and smoking simultaneously, as it may affect the drug’s action and show an effect on the brain, leading to severe drowsiness, sedation, and coma in severe cases.

Clobazam Interaction with Other Medicines  

Avoid taking clobazam 5 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Clobazam Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

7-chloro-1-methyl-5-phenyl-1,5-benzodiazepine-2,4-dione

Intake routine/cycle

Daily dose

Take clobazam exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 40 mg of clobazam per day, as it may cause severe overdosing effects like kidney and liver damage, dizziness, and severe low blood pressure. If you face any of the severe effects, meet the doctor.

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Directions for use 

1. Take clobazam exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking clobazam without your doctor’s approval, even if you feel better. 
3. If you forget to take clobazam, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 

Clobazam Summary 

Clobazam is a medicine used to control seizures (Lennox gastaut syndrome), especially in people with certain types of epilepsy. It is also used for supportive therapy for Dravet syndrome (a rare severe form of epilepsy), catamenial epilepsy, and anxiety. It belongs to a group of drugs called benzodiazepines, which help calm the brain by boosting a natural chemical that slows down nerve signals. It can cause some side effects, like feeling sleepy or tired, drooling and constipation. Avoid alcohol and grapefruit while taking it, as they can interfere with how the medicine works. Store it in a cool, dry place away from sunlight. Always take it exactly as your doctor tells you.

FAQ’s

Why are the uses of clobazam tablets?

Clobazam is a long-acting benzodiazepine used to treat anxiety and seizures like Lennox gastaut syndrome.

What are the side effects of the clobazam tablets?

Common side effects of clobazam use include drowsiness, dizziness, muscle weakness, unsteadiness, and trembling.

Which class does the clobazam drug belong to? 

Clobazam belongs to the class of benzodiazepines and is commonly used for the management of anxiety, seizures, and alcohol withdrawal symptoms.

What is the highest dose of clobazam?

It is not recommended to take more than 40 mg of Clobazam per day, as it may cause severe overdosing effects like extreme drowsiness, irritation, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor.

What is the dose of clobazam for the treatment of febrile seizures? 

For intermittent prevention of febrile seizures, clobazam can be given orally during the fever episode based on body weight: up to 5 kg – 5 mg/day; 5–10 kg – 10 mg/day; 11–15 kg – 15 mg/day; over 15 kg – 20 mg/day, usually as a single daily dose during the febrile period.

What is the dose of clobazam for a pediatric patient in dose per kg?

For pediatric patients, clobazam is usually started at 0.3–1 mg per kg of body weight per day, divided into two doses, and can be gradually increased to a typical range of 0.5–2 mg per kg per day, with adjustments made by the doctor based on response and tolerance.

Reference 

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 2789, Acetaminophen. Bethesda (MD): National Library of Medicine (US); [cited 2025 Sep 3]. Available from. 
2. Mayo Clinic. Clobazam (oral route) – Side effects & dosage. Rochester (MN): Mayo Foundation for Medical Education and Research; [updated 2025 Jul 31; cited 2025 Sep 3]. Available from. 
3. Practo. Clobazam – Uses, Dosage, Side Effects, Price, Composition. Bangalore (IN): Practo Technologies Pvt Ltd; [updated 2017 Nov 16; cited 2025 Sep 3]. Available from. 
4. Burn S, Chung C. Clobazam: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing. New York (NY): WebMD LLC; 2024 Jul 27 [cited 2025 Sep 3]. Available from. 
5. Griffin CE, Kaye AM, Bueno FR, Kaye AD. Clobazam. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan– [cited 2025 Sep 3]. Available from. 
6. Cerner Multum. Clobazam: Uses, Side Effects & Warnings. Drugs.com. Montvale (NJ): Drugs.com; 2024 Oct 9 [cited 2025 Sep 3]. Available from.

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.