Category- Allopathy
Medicine Highlights
| Uses | 1. To treat symptoms of Parkinson’s disease like stiffness, tremors, spasms 2. To improve muscle control in Parkinson’s disease. |
| Common Side Effects | 1. Dry mouth 2. Blurred vision or dilated pupils 3. Dizziness or drowsiness 4. Nausea, vomiting, or constipation 5. Confusion or nervousness 6. Fast heartbeat 7. Problems peeing 8. Feeling unusually weak or tired 9. Headache 10. Sleepiness or tiredness 11. Shaking |
| Additional Information | 1. Trihexyphenidyl can increase the risk of glaucoma. Get your eyes checked before using it. 2. Trihexyphenidyl may cause dryness of the mouth, nose, and throat. For relief, use sugarless candy or gum, or stay hydrated. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | The medicine should be taken orally |
Trihexyphenidyl Summary
Trihexyphenidyl is a medicine used to treat Parkinson’s disease and movement problems caused by other drugs. It works by relaxing muscles and reducing stiffness and tremors by balancing certain brain chemicals. Common side effects include dry mouth, blurred vision, constipation, and dizziness. People with glaucoma, severe stomach or urinary issues, or older adults with confusion should avoid it. It can interact with alcohol, some allergy or mental health medicines, and should be taken with caution. Store it in a cool, dry place away from sunlight and moisture.
Trihexyphenidyl Uses
Trihexyphenidyl 2 mg is an oral medicine belonging to the category of anticholinergics and is used for the following indications:
- Controlling symptoms of Parkinson’s disease
- Spasms
- Stiffness
- Tremors
Trihexyphenidyl side effects
More Common
- Dry mouth
- Blurred vision or dilated pupils
- Dizziness or drowsiness
- Nausea, vomiting, or constipation
- Confusion or nervousness
- Fast heartbeat
- Problems peeing
- Feeling unusually weak or tired
- Headache
- Sleepiness or tiredness
- Shaking
Less Common
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
- Excessive or no sweating
- Dry mouth
- Feeling very hot
- Feeling thirsty
- Not able to pee
- Neuroleptic malignant syndrome
- Salivary gland infection
- Hallucinations
- Slowed gut movement
How Trihexyphenidyl works
Trihexyphenidyl works by blocking the action of acetylcholine, a chemical that becomes overly active in the brains of people with Parkinson’s disease due to reduced dopamine levels. This imbalance leads to tremors, stiffness, and poor muscle control. By attaching to muscarinic receptors (especially M1) in motor regions of the brain, trihexyphenidyl calms the excessive signals that cause these symptoms. Think of it as turning down the volume on a noisy system so smoother movement can return. For patients, this means fewer tremors and a better chance of moving with ease and confidence.
Safety Measures and Warning
Pregnancy
Trihexyphenidyl should be used during pregnancy only if required, as its safety hasn’t been established. Animal studies are lacking, and human data is limited. It is classified as Category C by the US FDA, meaning potential risks to the fetus exist. So, consult a doctor before using it.
Breastfeeding
Trihexyphenidyl passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop amitriptyline.
Previous Mental Health Problems
Patients having mental health issues can experience potential symptoms, like hallucinations, confusion, dizziness and sedation, so meet with a doctor before using them
Kidney and Liver Problems
Patients suffering from kidney and liver problems are more prone to kidney and liver damage as they are converted into a less toxic form in the liver and kidney; they get affected, so consult a doctor before using them.
Allergic Conditions
Few drugs cause severe allergies. Trihexyphenidyl is one of the medicines with the highest chance of getting allergies. So, it is recommended to take the medicine after a proper examination by the doctor.
Trihexyphenidyl Interaction with Food Product
Taking alcohol and smoking simultaneously can increase the effect of the drug on the brain, leading to severe drowsiness and sedation, as they act directly on the brain.
Trihexyphenidyl Interaction with Other Medicines
Avoid taking Trihexyphenidyl 2 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Trihexyphenidyl Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol hydrochloride
Intake routine/cycle
Daily Dose
Take trihexyphenidyl exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Do not take more than 20 mg of trihexyphenidyl per day, as it may cause severe adverse effects like extreme drowsiness, confusion, low blood pressure, unconsciousness, dry mouth, high fever, vision problems, and hallucinations. If you face any severe effects, meet the doctor immediately.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Directions for use
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
- Take trihexyphenidyl exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking trihexyphenidyl without your doctor’s approval, even if you feel better.
FAQ’s
Which class does the trihexyphenidyl hydrochloride belong to?
Trihexyphenidyl hydrochloride is an antiparkinsonian drug belongs to the class of Anticholinergics used to control muscle effects in Parkinson’s disease.
What are trihexyphenidyl hydrochloride trade names?
Trihexyphenidyl has different trade names like Artane, Tritane, and Trihexane. Although Trihexyphenidyl has different brand names that are endorsed by marketing companies, the salt name remains the same. Many of the brands fail to pass the CDSCO standard quality test, and it’s the time when Saya Care steps in, and we provide the medicine with a quality test report.
What is trihexyphenidyl hydrochloride 2 mg price?
A pack of 10 tablets of trihexyphenidyl costs rupees 8 at Saya Care. Which is 80% less than the market price.
What are trihexyphenidyl hydrochloride side effects?
Trihexyphenidyl has various side effects, like neuroleptic malignant syndrome, salivary gland infections, and various allergic reactions.
Reference
- Mayo Clinic. Trihexyphenidyl (oral route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; 2023 [cited 2025 Jul 2]. Available from.
- Patel R, Cherian J. Trihexyphenidyl. [Updated 2023 Jul 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan– [cited 2025 Jul 2]. Available from.
- Chabot S. Trihexyphenidyl (Artane): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing [Internet]. New York: WebMD; 2024 Oct 16 [cited 2025 Jul 2]. Available from.
- Cerner Multum. Trihexyphenidyl: Uses, Side Effects & Warnings [Internet]. Drugs.com; 2025 Jan 20 [cited 2025 Jul 2]. Available from.
- National Center for Biotechnology Information. PubChem Compound Summary for CID 6274, Trihexyphenidyl hydrochloride [Internet]. Bethesda (MD): National Library of Medicine (US); [cited 2025 Jul 2]. Available from.
Authors
Siva Krishna Adithya Bhumireddy completed Bachelor of Pharmacy from GIET School of Pharmacy affiliated to Andhra University and from his 3rd year of graduation itself he was working as a freelance Medical and Publication writer and having expertise in Systematic reviews and clinical research. With his keen interest and skills in research and documentation practices he also reviewed more than 100 manuscripts from international journals like Elsevier, Springer Nature, Sage Journals and all the manuscripts were indexed and appeared in Pub Med, Scopus and Web of Science databases and received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published few systematic, narrative reviews and few chapters of international expertise.