Olmesartan 20 mg + Amlodipine 5 mg

Category- Allopathy

About Olmesartan 20 mg + Amlodipine 5 mg

Olmesartan 20 mg + Amlodipine 5 mg tablet is used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload. Common side effects of  Olmesartan 20 mg + Amlodipine 5 mg are headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes. People with serious liver problems, very low blood pressure, or heart issues, or women who are pregnant or breastfeeding, should inform their doctor before using it. Drinking grapefruit juice with this medication makes it stronger and increases side effects, so it’s best skipped. Always store this medicine in a cool, dry place away from sunlight, and keep it in its original packaging. Taking more than 100 mg of this medicine daily can cause overdosing effects like severe hypotension, dizziness, fainting, and potentially life-threatening cardiovascular collapse.

Medicine Highlights

Olmesartan 20 mg + Amlodipine 5 mg  Uses

Olmesartan 20 mg + Amlodipine 5mg is an oral tablet belonging to the category of antihypertensives. Olmesartan 20 mg + Amlodipine 5 mg is used to treat high blood pressure and chest pain.

Olmesartan 20 mg + Amlodipine 5 mg  side effects 

More Common

1. Headache 
2. Dizziness 
3. Constipation 
4. Skin rash 
5. Decreased blood pressure 
6. Nausea 

Less Common 

1. Lightheadedness 
2. Palpitations 
3. Oedema (accumulation of water in the tissues)

How Olmesartan 20 mg + Amlodipine 5 mg works 

Olmesartan 20 mg + Amlodipine 5 mg works by helping the blood vessels relax and widen, which makes it easier for blood to flow and lowers blood pressure. It blocks three types of calcium channels—L-type, T-type, and N-type that normally tighten blood vessels and make the heart work harder. It also reduces angiotensin, which causes blood pressure.

Safety Measures and Warning 

Pregnancy

Pregnant women are not recommended to take Olmesartan 20 mg + Amlodipine 5 mg , as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.

Breastfeeding

 Olmesartan 20 mg + Amlodipine 5 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using them

Olmesartan 20 mg + Amlodipine 5 mg  Interaction with Food Product 

Olmesartan 20 mg + Amlodipine 5 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Olmesartan 20 mg + Amlodipine 5 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.

Olmesartan 20 mg + Amlodipine 5 mg  Interaction with Other Medicines  

Avoid taking Olmesartan 20 mg + Amlodipine 5 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Olmesartan 20 mg + Amlodipine 5 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Olmesartan- 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid

Amlodipine-3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Intake routine/cycle

Daily dose

Take Olmesartan 20 mg + Amlodipine 5 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 200 mg of Olmesartan + Amlodipine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary. 

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Olmesartan 20 mg + Amlodipine 5 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking Olmesartan 20 mg + Amlodipine 5 mg without your doctor’s approval, even if you feel better. 
3. If you forget to take Olmesartan 20 mg + Amlodipine 5 mg, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

FAQ’s

What is the Olmesartan 20 mg + Amlodipine 5 mg mechanism of action?

Olmesartan 20 mg + Amlodipine 5 mg works by helping the blood vessels relax and widen, which makes it easier for blood to flow and lowers blood pressure. It blocks three types of calcium channels—L-type, T-type, and N-type that normally tighten blood vessels and make the heart work harder. By easing these signals, Olmesartan 20 mg + Amlodipine 5 mg opens the pathways and lightens the heart’s load.

What are the uses of Olmesartan 20 mg + Amlodipine 5 mg tablets?

Olmesartan 20 mg + Amlodipine 5 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.

What are the side effects of Olmesartan 20 mg + Amlodipine 5 mg?

Common side effects of Olmesartan 20 mg + Amlodipine 5 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.

Reference  

1. Li X, Wang C, Li T, Liu Y, Liu S, Tao Y, Ma Y, Gao X, Cao Y. Bioequivalence of amlodipine tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study. BMC Pharmacol Toxicol. 2020 Nov 19;21(1):80. Available from. 
2. National Center for Biotechnology Information. PubChem Compound Summary for CID 115193, S-Amlodipine. Bethesda (MD): National Library of Medicine (US). Available from. 
3. Cerner Multum. Amlodipine: Uses, Side Effects & Warnings [Internet]. Drugs.com; 2025 Mar 7 [cited 2026 Feb 3]. Available from. 
4. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 158781, Olmesartan; [cited 2026 Apr. 24]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.