Category- Allopathy
About Trypsin 48mg + Rutoside 100mg + Bromelain 90mg
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablet is used to reduce pain, swelling, and inflammation, especially after injury, surgery, sprains, fractures, and joint problems. It is often given when there is tissue swelling and the body needs help healing faster. This combination is mainly used as a pain-relieving and anti-swelling medicine in musculoskeletal conditions.
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg works through a triple action: Trypsin and Bromelain are enzymes that help improve blood flow to the affected area and reduce swelling, while Rutoside is an antioxidant that protects tissues from damage and further helps reduce inflammation. Together, they help relieve pain, reduce puffiness, and support recovery. It is usually taken once or twice daily as prescribed by the doctor. Common side effects may include nausea, vomiting, diarrhoea, stomach upset, rash, or mouth irritation. Use with caution in people with liver disease, kidney disease, bleeding disorders, pregnancy, or breastfeeding.
Medicine Highlights
| Uses | 1. To reduce pain and swelling after injury and surgery 2. To help in sprains, muscle injury, and soft tissue injury 3. To relieve joint pain and inflammation in arthritis 4. To support faster healing in fractures and tissue damage |
| Common Side Effects | 1. Nausea 2. Vomiting 3. Diarrhea 4. Stomach discomfort 5. Skin rash 6. Mouth sores / irritation 7. Dizziness |
| Additional Information | 1. Avoid consuming alcohol and tobacco with this medicine 2. It is usually taken once daily, preferably in the evening, or as prescribed by your doctor. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medicine orally with a sip of water. |
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Uses
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg is an oral medicine belonging to the class of Anti-inflammatory enzyme combination / Pain-relieving enzyme medicine. Trypsin 48mg + Rutoside 100mg + Bromelain 90mg is used to prevent pain and treat conditions like:
- Pain and swelling after surgery , injury or trauma
- Sprains and muscle strain
- Fractures (bone injury)
- Arthritis-related pain and joint inflammation (like osteoarthritis or rheumatoid arthritis)
Directions for Use
- Take Trypsin 48mg + Rutoside 100mg + Bromelain 90mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Trypsin 48mg + Rutoside 100mg + Bromelain 90mg without your doctor’s approval, even if you feel better.
- If you forget to take Trypsin 48mg + Rutoside 100mg + Bromelain 90mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Side Effects
More Common
- Nausea
- Vomiting
- Diarrhoea
- Stomach pain / stomach upset
- Bloating
- Skin rash
- Mouth sores or mouth irritation
- Mild dizziness
Less Common
- Itching
- Allergic reaction
- Swelling of lips/face (rare but serious)
- Breathing difficulty (rare, needs urgent help)
- Increased bleeding tendency in sensitive people
How Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Works
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg helps reduce pain, swelling, and inflammation after injury, surgery, sprain, fracture, or joint pain. Trypsin and Bromelain are enzymes that reduce swelling by breaking down damaged proteins and improving healing, while Rutoside is an antioxidant that protects tissues and improves blood flow. Together, they reduce swelling, relieve pain, and support faster recovery.
Safety Measures and Warning
Allergic Reactions
If you have ever had an allergic reaction to Trypsin 48mg + Rutoside 100mg + Bromelain 90mg such as rash, itching, swelling, shortness of breath inform your doctor before they prescribe this medicine.
Bleeding disorders / Blood thinners
If you have bleeding problems, stomach ulcers, or if you take blood-thinning medicines, bromelain may increase bleeding risk. Always communicate with your doctor about your past disease/medication history.
Children
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg should not be used in children, as it may affect brain development and cause serious side effects like seizures.
Liver disease
Tell your doctor if you are suffering with severe liver impairment, as Trypsin 48mg + Rutoside 100mg + Bromelain 90mg metabolizes the liver and may worsen liver function.
Kidney problems
Tell your doctor if you are suffering from kidney disease, as the drug may accumulate and increase the risk of side effects.
Pregnancy
Avoid Trypsin 48mg + Rutoside 100mg + Bromelain 90mg if you’re pregnant because it can be harmful to the baby.
Breastfeeding
It is not clear if Trypsin 48mg + Rutoside 100mg + Bromelain 90mg passes into breast milk. To be safe, consult your doctor before using it if you are breastfeeding, to avoid any possible harm to your baby.
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Interaction with Food Products
Take Trypsin 48mg + Rutoside 100mg + Bromelain 90mg after food, to avoid stomach upset. Avoid alcohol unless your doctor says it is safe, as it may increase stomach irritation. If you are allergic to pineapple, inform your doctor before taking this medicine because bromelain is obtained from pineapple and may trigger an allergic reaction in some people.
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Interaction with Other Medications
Avoid taking Trypsin 48mg + Rutoside 100mg + Bromelain 90mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) Name
Trypsin: Tryptase, Parenzyme, Cocoonase
Rutoside: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
Bromelain: Bromelain
Intake routine/cycle
Daily dose
Take Trypsin 48mg + Rutoside 100mg + Bromelain 90mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take trypsin 48mg + rutoside 100mg + bromelain 90mg in more than the prescribed dose. Taking too much of this medicine may cause nausea, vomiting, diarrhoea, stomach pain, dizziness, rash, or increased risk of bleeding in some people. In rare cases, it may also cause severe allergic reaction or worsening stomach irritation. Seek immediate medical attention if any of these occur.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
FAQ’s
What are the uses of Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablets?
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablets are used to reduce pain, swelling, and inflammation in the body. They are commonly used after surgery, injury, sprain, fracture, muscle pain, joint pain, and soft tissue swelling. This medicine helps reduce swelling faster and supports better healing.
What are the side effects of Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablets?
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg is usually well tolerated, but some people may get nausea, vomiting, diarrhoea, stomach upset, skin rash, itching, or mild dizziness. In rare cases, it may cause allergy, swelling, or breathing difficulty. If severe side effects happen, seek medical help immediately.
When should Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablets be taken?
Trypsin 48mg + Rutoside 100mg + Bromelain 90mg tablets are usually taken as prescribed by the doctor, commonly once or twice daily depending on the condition. They can be taken with or without food, but taking them after food may help reduce stomach discomfort. Take them at the same time each day for better results.
Reference
- PubChem. RUTOSIDE (rutin) [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Apr 9]. Available from
- PubChem. Trypsin [Internet]. Nih.gov. PubChem; 2026. Available from
- PubChem. Bromelains [Internet]. Nih.gov. PubChem; 2025. Available from
- Sarawanan T, Man RC, Arshad ZIM, Shaarani SM. Bromelain from pineapple: A mini review of its industrial applications and future prospects. Bioresource Technology Reports [Internet]. 2025 Aug 26;31:102275. Available from
- Rutin [Internet]. go.drugbank.com. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.