Category- Allopathy
About Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg (sr) 75 mg + Etoricoxib 60 mg
Gliclazide 60 mg + Metformin (SR) 500 mg + Pioglitazone 15 mg tablet is an antidiabetic medicine used to manage blood sugar level in type 2 diabetes mellitus. Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg helps lower high blood sugar levels and improves the body’s response to insulin. Gliclazide increases insulin release from the pancreas, Metformin (SR) reduces sugar production in the liver and improves insulin sensitivity, and Pioglitazone helps the body use insulin better.
Together, they help control blood sugar and reduce the risk of diabetes complications. Common side effects of Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg include low blood sugar, nausea, stomach upset, diarrhea, bloating, weight gain, swelling, headache, and dizziness. It should be taken with food, meals should not be skipped, and alcohol should be avoided. It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Medicine Highlights
| Uses | To manage blood sugar level in type 2 diabetes mellitus |
| Common Side Effects | 1. Low blood sugar (hypoglycemia) 2. Nausea 3. Stomach pain 4. Diarrhea 5. Bloating 6. Weight gain 7. Swelling in feet or ankles 8. Headache 9. Weakness 10. Dizziness |
| Additional Information | 1. Take it exactly as prescribed by your doctor. Avoid smoking, as it can reduce the medicine’s effect. 2. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medication orally with a sip of water. |
Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Uses
Gliclazide 60 mg + Metformin (SR) 500 mg + Pioglitazone 15 mg tablet is an antidiabetic medicine. Gliclazide 60 mg + Metformin (SR) 500 mg + Pioglitazone 15 mg is used to manage sugar level in type 2 diabetes mellitus
Directions for Use
- Take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg without your doctor’s approval, even if you feel better.
- If you forget to take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Side Effects
More Common
- Low blood sugar
- Nausea
- Diarrhea
- Stomach pain
- Bloating
- Headache
- Dizziness
- Weakness
Less Common
- Weight gain
- Swelling in feet or ankles
- Vomiting
- Loss of appetite
- Metallic taste in mouth
- Skin rash
- Blurred vision
- Tiredness
How Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Works
Gliclazide helps the pancreas release more insulin. Metformin (SR) reduces the amount of sugar made by the liver and helps the body use insulin better. Pioglitazone improves insulin sensitivity, so the body can use sugar more effectively. Together, they help lower blood sugar and improve diabetes control.
Safety Measures and Warning
Allergic Reactions
Do not take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg if you are allergic to pregabalin, etoricoxib, sulfa drugs, or other painkillers. It may cause rash, itching, swelling, or breathing difficulty. Always inform your doctor about any past medicine allergy.
Liver Disease
If you have liver disease, use Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg carefully and only on doctor’s advice. It may increase the risk of liver damage.
Kidney problems
If you have kidney disease, consult your doctor before taking it. Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg may worsen kidney function.
Heart problems/ swelling
If you have heart failure or swelling in your legs, tell your doctor. Pioglitazone may cause fluid retention and worsen swelling.
Pregnancy
If you are pregnant or planning pregnancy, take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg only if your doctor advises it. It may harm the baby, especially in later pregnancy.
Breastfeeding
If you are breastfeeding, ask your doctor before taking it. Some amount of Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg may pass into breast milk and affect the baby.
Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Interaction with Food Products
Take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mgafter food to avoid stomach upset. Do not skip meals, because it may cause low blood sugar. Avoid alcohol, as it can increase the risk of low blood sugar and side effects. Eat meals on time and follow a healthy diabetic diet for better sugar control.
Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Interaction with Other Medications
Avoid taking Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) Name
Gliclazide: 1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
Metformin: 3-(diaminomethylidene)-1,1-dimethylguanidine
Pioglitazone: 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Intake routine/cycle
Daily dose
Take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take Gliclazide 60 mg + Metformin (sr) 500 mg + Pioglitazone 15 mg more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
FAQ’s
What are the use of metformin?
Metformin is a medicine belonging to alpha-glucosidase inhibitors and used to control blood glucose levels and sometimes used in females for polycystic ovarian syndrome.
Which class does metformin belong to?
Metformin belongs to the class of biguanides used to treat diabetes and control blood sugar levels.
What is the mechanism of action of metformin?
Metformin lowers blood sugar mainly by reducing glucose production in the liver and improving insulin sensitivity in muscles and fat, helping the body use sugar more effectively. It does this by activating the cell’s energy sensor AMPK, which shifts the body into a “use fuel wisely” mode without causing low sugar.
Can metformin cause weight gain?
Metformin is not usually linked to weight gain; in fact, it often helps with modest weight loss or weight stability by improving insulin sensitivity. Rarely, some people may notice weight gain due to factors like fluid retention, increased appetite, or lifestyle influences.
What are the side effects of Pioglitazone tablet?
Common side effects of pioglitazone may include weight gain, swelling in feet or ankles, headache, body pain, weakness, and mild stomach upset. In some people, it may also cause fluid retention, so it should be used carefully in patients with heart problems.
What are the uses of Pioglitazone?
Pioglitazone tablet is used to treat type 2 diabetes mellitus. It helps the body use insulin better, which lowers high blood sugar levels. It is usually used along with diet, exercise, and sometimes other diabetes medicines for better sugar control.
How does Gliclazide work?
Gliclazide works by helping the pancreas release more insulin. Insulin is the hormone that helps move sugar from the blood into the body’s cells. This helps lower blood sugar levels and improves diabetes control.
What are the uses of Gliclazide tablets?
Gliclazide tablet is used to treat type 2 diabetes mellitus. It helps lower high blood sugar levels in adults when diet, exercise, and lifestyle changes alone are not enough. It also helps reduce the risk of diabetes-related complications such as nerve, kidney, and eye problems.
Reference
- PubChem. Gliclazide [Internet]. Nih.gov. PubChem; 2019. Available from
- DrugBank. Gliclazide [Internet]. go.drugbank.com. 2005. Available from
- NHS . Gliclazide [Internet]. NHS. 2019. Available from
- PubChem. Metformin [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- PubChem. Pioglitazone [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Corcoran C, Jacobs TF. Metformin [Internet]. National Library of Medicine. StatPearls Publishing; 2023. Available from
- Singh G, Correa R. Pioglitazone [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from
- Pioglitazone (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. www.mayoclinic.org. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.