Category- Allopathy
About Pregabalin (sr) 75 mg + Etoricoxib 60 mg
Pregabalin (SR) 75 mg + Etoricoxib 60 mg tablet is a combination medicine. Pregabalin (sr) 75 mg + Etoricoxib 60 mg used to treat nerve pain (neuropathic pain) and pain associated with inflammation. It is commonly prescribed for conditions like diabetic nerve pain, post-herpetic neuralgia (pain after shingles), spinal nerve pain, sciatica, slipped disc-related nerve pain, and chronic musculoskeletal pain with burning or tingling symptoms. Pregabalin is an anti-nerve pain medicine that reduces abnormal pain signals sent by damaged nerves to the brain, while Etoricoxib is a COX-2 selective painkiller that helps reduce pain, swelling, and inflammation by blocking certain chemical messengers in the body.
Common side effects of Pregabalin (sr) 75 mg + Etoricoxib 60 mg include sleepiness, dizziness, dry mouth, blurred vision, swelling, weight gain, stomach pain, headache, and difficulty concentrating. Rare but serious side effects may include allergic reaction, severe swelling, stomach ulcer or bleeding, kidney problems, liver problems, chest pain, or high blood pressure. Pregabalin (sr) 75 mg + Etoricoxib 60 mg should be used carefully in people with kidney disease, liver disease, heart disease, high BP, stomach ulcer, pregnancy, or breastfeeding, and alcohol should be avoided because it can worsen drowsiness and side effects. It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Medicine Highlights
| Uses | 1. To treat nerve pain (neuropathic pain) caused by nerve damage 2. To treat post-herpetic neuralgia (pain after shingles) 3. To treat pain due to spinal cord injury or slipped disc with nerve pain 4. To help reduce chronic musculoskeletal pain with nerve involvement 5. To treat sciatica or radiating nerve pain |
| Common Side Effects | 1. Sleepiness or drowsiness 2. Dizziness 3. Dry mouth 4. Blurred vision 5. Swelling in feet or hands (edema) 6. Weight gain 7. Difficulty in concentration 8. Tiredness or weakness 9. Stomach pain or discomfort 10. Headache 11. Increased appetite 12. Nausea |
| Additional Information | 1. Take it exactly as prescribed by your doctor. Avoid smoking, as it can reduce the medicine’s effect. 2. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medication orally with a sip of water. |
Pregabalin (sr) 75 mg + Etoricoxib 60 mg Uses
Pregabalin (SR) 75 mg + Etoricoxib 60 mg is a combination medicine. Pregabalin (sr) 75 mg + Etoricoxib 60 mg is used to treat the following conditions:
- Neuropathic pain (nerve pain)
- Post-herpetic neuralgia (pain after shingles)
- Sciatica or radiating nerve pain
- Slipped disc / spinal nerve compression pain
- Chronic musculoskeletal pain with burning, tingling, or nerve irritation
Directions for Use
- Take Pregabalin (sr) 75 mg + Etoricoxib 60 mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Pregabalin (sr) 75 mg + Etoricoxib 60 mg without your doctor’s approval, even if you feel better.
- If you forget to take Pregabalin (sr) 75 mg + Etoricoxib 60 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Pregabalin (sr) 75 mg + Etoricoxib 60 mg Side Effects
More Common
- Dizziness
- Sleepiness
- Drowsiness
- Dry mouth
- Blurred vision
- Swelling of feet/hands
- Weight gain
- Difficulty in concentration
- Tiredness / weakness
- Stomach pain
- Headache
- Increased appetite
Less Common
- Nausea
- Vomiting
- Constipation
- Indigestion
- Acidity
- Skin rash
- Tremors
- Mood changes
- Low energy
- Increased blood pressure
How Pregabalin (sr) 75 mg + Etoricoxib 60 mg Works
Pregabalin acts on the nerves and brain by reducing abnormal electrical signals and decreasing the release of certain chemicals involved in pain transmission. This helps reduce burning, tingling, shooting, or nerve-related pain. Etoricoxib is a COX-2 selective painkiller (NSAID) that blocks chemical messengers responsible for pain, swelling, and inflammation called prostaglandins. Together, they help relieve nerve pain along with inflammation-related pain, improve comfort, and support better movement. It works by blocking pain signals and reducing inflammatory mediators.
Safety Measures and Warning
Allergic Reactions
Do not take Pregabalin (sr) 75 mg + Etoricoxib 60 mg if you are allergic to pregabalin, etoricoxib, sulfa drugs, or other painkillers (NSAIDs). It may cause rash, itching, swelling, or breathing difficulty. Always inform your doctor about any past medicine allergy.
Liver Disease
If you have liver disease, use Pregabalin (sr) 75 mg + Etoricoxib 60 mg carefully and only on doctor’s advice. It may increase the risk of liver damage.
Kidney problems
If you have kidney disease, consult your doctor before taking it. Pregabalin (sr) 75 mg + Etoricoxib 60 mg may worsen kidney function.
Stomach ulcer or stomach bleeding
If you have stomach ulcer, black stools, or history of stomach bleeding, take Pregabalin (sr) 75 mg + Etoricoxib 60 mg only if the doctor advises. Diclofenac can worsen ulcers and cause serious bleeding. Communicate with your doctor about your medical condition.
Heart problems or high blood pressure
If you have heart disease, swelling, fluid retention, stroke history, or high BP, use it carefully. Etoricoxib may increase blood pressure and cardiovascular risk in some people.
Pregnancy
If you are pregnant or planning pregnancy, take Pregabalin (sr) 75 mg + Etoricoxib 60 mg only if your doctor advises it. It may harm the baby, especially in later pregnancy.
Breastfeeding
If you are breastfeeding, ask your doctor before taking it. Some amount of Pregabalin (sr) 75 mg + Etoricoxib 60 mg may pass into breast milk and affect the baby.
Pregabalin (sr) 75 mg + Etoricoxib 60 mg Interaction with Food Products
Pregabalin (sr) 75 mg + Etoricoxib 60 mg should be taken after food, to avoid stomach discomfort. Avoid alcohol, as it can increase sleepiness, dizziness, and poor concentration. If you have acidity or gastritis, do not take it on an empty stomach.
Pregabalin (sr) 75 mg + Etoricoxib 60 mg Interaction with Other Medications
Avoid taking Pregabalin (sr) 75 mg + Etoricoxib 60 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Pregabalin (sr) 75 mg + Etoricoxib 60 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) Name
Etoricoxib: 5-Chloro-6′-methyl-3-(4-(methylsulfonyl)phenyl)-2,3′-bipyridine
Pregabalin: (3S)-3-(aminomethyl)-5-methylhexanoic acid
Intake routine/cycle
Daily dose
Take Pregabalin (sr) 75 mg + Etoricoxib 60 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take this combination more than the prescribed dose by doctor, as it may cause severe overdose symptoms like nausea, vomiting, headache, tremors, restlessness, and rapid heartbeat.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
FAQ’s
What are the uses of pregabalin tablets?
Pregabalin tablets are used to treat nerve pain, such as burning, tingling, or shooting pain caused by diabetes, shingles, or nerve damage. They are also used to help control certain seizures (fits), to treat fibromyalgia (long-lasting body pain), and sometimes to treat anxiety, if prescribed by a doctor.
What are the side effects of pregabalin?
Common side effects of pregabalin include sleepiness, dizziness, tiredness, dry mouth, blurred vision, swelling in hands or feet, weight gain, and poor concentration. Rare but serious side effects may include allergic reaction, breathing difficulty, severe swelling, or mood changes such as depression or suicidal thoughts.
What drug class does pregabalin belong to?
Pregabalin belongs to the class of medicines called anticonvulsants or anti-epileptic medicines. It is also commonly used as a nerve pain relieving medicine.
What is the mechanism of action of pregabalin?
Pregabalin works by calming overactive nerves in the brain and body. It reduces the release of certain chemical messengers that send pain signals and can also trigger seizures. This helps in nerve pain, fits, and sometimes anxiety.
What drug class does etoricoxib belong to?
Etoricoxib, is an NSAID used to relieve pain in certain conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout.
Can I use etoricoxib for tooth pain?
Yes, as etoricoxib is a pain killer it is used for toothache and during dental surgeries.
Does etoricoxib causes hepatotoxicity?
Yes, as etoricoxib is an NSAID it can cause hepatotoxicity but less when compared to other NSAID’s
What are the uses of etoricoxib tablet?
Etoricoxib 60 mg is an oral medicine belonging to the class of nonsteroidal anti-inflammatory drugs (NSAIDs) it is used to reduce pain, swelling and inflammation in diseases like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout.
What are side effects of Etoricoxib?
Common side effects of etoricoxib include Abdominal discomfort, Nausea, Tiredness, Edema (swelling), Headache and Constipation.
Reference
- Etoricoxib [Internet]. go.drugbank.com. Available from
- PubChem. Etoricoxib [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Pregabalin Dosage Guide + Max Dose, Adjustments [Internet]. Drugs.com. Available from
- Cross AL, Viswanath O, Sherman A l. Pregabalin [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2024. Available from
- PubChem. Pregabalin [Internet]. Nih.gov. PubChem; 2025. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.