Category- Allopathy
About Imipramine 25 mg
Imipramine 25 mg belongs to the tricyclic antidepressant (TCA) class. It is approved for treatment of major depression and bed-wetting (enuresis) in children over 6 years. It is also used off-label for panic disorder, anxiety, and chronic pain. It works by increasing the levels of serotonin and norepinephrine in the brain, which improves mood and reduces bladder overactivity. Common side effects include dry mouth, constipation, blurred vision, dizziness, sweating, and trouble sleeping. Taking this medicine along with alcohol can increase drowsiness. People with heart disease, glaucoma, seizures, or thyroid problems or those who are pregnant or breastfeeding should avoid it. Taking more than 300 mg per day can cause severe drowsiness, confusion, seizures, irregular heartbeat, coma, or even death.
Medicine Highlights
| Uses | 1. To treat depression 2. To treat bed wetting in children above 6 years of age. |
| Common Side Effects | 1. Constipation 2. Inability to empty your bladder 3. Dry mouth 4. Drowsiness 5. Dizziness 6. Confusion 7. Blurred vision 8. Nausea and vomiting |
| Additional Information | 1. Consume the medicine at bedtime to get maximum effect with fewer side effects. 2. It is also used off label for panic disorder, anxiety, and chronic pain. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | Take this medicine orally with a sip of water |
Imipramine 25 mg Uses
Imipramine 25 mg is an oral tablet belonging to the class of tricyclic antidepressants. Imipramine 25 mg is used for the following indications:
- Depression
- Nighttime bedwetting in children above 6 years
Imipramine 25 mg side effects
More Common
- Feeling dizzy, sleepy, tired, or weak.
- Constipation, diarrhea, stomach pain, upset stomach, throwing up, or feeling less hungry.
- Dry mouth.
- Change in taste.
- Mouth irritation or mouth sores.
- Weight gain.
- Sweating a lot.
- Flushing.
- Hair loss.
- Headache.
Less Common
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
- Suicidal thoughts
- Increased mood
- Arrhythmia
How Imipramine 25 mg works
Imipramine 25 mg works by boosting the brain’s natural feel-good chemicals, like serotonin and norepinephrine. In depression or nerve pain, these chemicals decrease. Normally, the brain clears them away quickly like a vacuum. Imipramine 25 mg slows this process down, helping the chemicals stay longer and do their job. This lifts mood and eases pain.
Safety Measures and Warning
Pregnancy
Imipramine 25 mg is not confirmed safe for use during pregnancy. It’s classified as a Category C drug, meaning animal studies suggest possible risks like heart defects or miscarriage, but human data is lacking. Always consult a doctor before using it.
Breastfeeding
Imipramine 25 mg passes into breast milk. Inform your healthcare provider if you are breastfeeding or planning to breastfeed. They will advise you whether to stop breastfeeding or discontinue Imipramine 25 mg.
Heart Problems
Imipramine 25 mg can affect the functioning of the heart and can reduce blood pressure. So, get a recommendation from the doctor before using it.
Past Mental Health Issues
Patients having past mental health problems can experience potential side effects and symptoms like confusion and hallucinations, so inform your doctor before using.
Imipramine 25 mg Interaction with Food Product
Avoid consuming alcohol and smoking after taking Imipramine 25 mg, as they increase or decrease drug action and can also cause severe drowsiness and sedation, as they act on the brain directly. Take the patient to the doctor in case of any side effects.
Imipramine 25 mg Interaction with Other Medicines
Avoid taking Imipramine 25 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Imipramine 25 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine
Intake routine/cycle
Daily dose
Take Imipramine 25 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take more than 300 mg of Imipramine 25 mg per day, as it may cause severe adverse effects like extreme drowsiness, confusion, low blood pressure, unconsciousness, difficulty in breathing, irregular heartbeat, and vision loss.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture
- Keep out of reach of children
Directions for use
- Take imipramine 25 mg exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking imipramine 25 mg without your doctor’s approval, even if you feel better.
- If you forget to take imipramine 25 mg, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What are the side effects of imipramine 25 mg tablets?
Imipramine 25 mg, commonly used for the treatment of depression and anxiety, can also have side effects that include severe drowsiness, mania, and arrhythmias. So, people should be careful while taking medicine.
What is the overdosing amount of imipramine 25 mg?
Taking more than 300 mg causes overdose and produces toxic effects like fall in pressure, unconsciousness, numbness, and vision problems
What does Imipramine 25 mg’s long-term use cause?
It causes dependence, trouble sleeping, and addiction-seeking behaviors.
Which category of medicine does imipramine 25 mg belong to?
Imipramine 25 mg belongs to the category of tricyclic antidepressants and is used to treat depression and anxiety, but it should only be used under medical prescription.
Reference
- PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004-. PubChem Compound Summary for CID 3696, Imipramine 25 mg; [cited 2026 Mar. 25]. Available from.
- Drugs.com. Imipramine 25 mg: Uses, Side Effects & Warnings [Internet]. Drugs.com; 2025 Jul 24 [cited 2026 Mar 25]. Available from.
- Hester S, Burn S. Imipramine 25 mg: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing [Internet]. WebMD; 2024 Aug 7 [cited 2026 Mar 25]. Available from.
- Mayo Clinic. Imipramine 25 mg (oral route): Side effects & dosage [Internet]. Merative, Micromedex; 2026 Mar 1 [cited 2026 Mar 25]. Available from.
Authors
Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.