Category- Suppliments
Medicine Highlights
| Uses | 1. To treat neuropathic pain (e.g. diabetic neuropathy, nerve damage) 2. To treat and support nerve regeneration and repair 3. To treat and improve energy metabolism and cellular function 4. To treat and correct vitamin B deficiencies 5. To treat and aid red blood cell formation |
| Common side effects | 1. Nausea or vomiting 2. Stomach upset or diarrhea 3. Headache or dizziness 4. Skin rash or itching 5. Numbness or tingling (with excess Vitamin B6) 6. Low blood sugar (with high doses of Alpha Lipoic Acid) 7. Loss of appetite |
| Additional Information | 1. Can be taken with or without food, but taking it after meals may help reduce stomach upset. 2. Take at the same time each day to maintain consistent levels in the body. 3. Do not crush, chew, or break the tablet. |
| Storage | 1- The medicine should be stored in a cool and dry place 2- Keep away from sunlight and moisture 3- Store the medicine at a temperature below 25°C |
| How to Take This Medicine | The medicine should be taken orally with a sip of water. |
Methylcobalamine + Alpha Lipoic Acid + Thiamine + Pyridoxine + Folic Acid Uses
This medicine comes under the multivitamin / B-complex supplement category, and it is used to treat and relieve the symptoms of the following:
- Nutritional deficiencies (especially B-vitamins)
- Tingling, numbness, or burning sensations in the hands and feet (neuropathy symptoms)
- Low energy levels by boosting metabolism
- Reduced red blood cell count by supporting healthy RBC production
- Weak immunity by strengthening the immune system
side effects
More Common
- Nausea or vomiting
- Stomach upset or diarrhea
- Headache or dizziness
- Skin rash or itching
- Numbness or tingling (with excess Vitamin B6)
- Low blood sugar (with high doses of Alpha Lipoic Acid)
- Loss of appetite
Less common
- Constipation.
- Change in color of stool to green.
- Diarrhea.
- Belly pain.
Directions for use
- Take this medicine exactly as prescribed by your doctor, regularly at the same time each day.
- Do not stop taking medication without your doctor’s approval, even if you feel better.
- If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it.
How Methylcobalamine + Alpha Lipoic Acid + Thiamine + Pyridoxine + Folic Acid works
Below is the list of how each ingredient functions:
Methylcobalamin (Vitamin B12)
Supports healthy nerve function, promotes red blood cell production, and helps prevent anemia.
Folic Acid (Vitamin B9)
Essential for cell growth, DNA formation, and preventing certain types of anemia; also important during pregnancy for fetal development.
Alpha Lipoic Acid
A powerful antioxidant that protects cells from damage, improves nerve health, and supports energy production in the body.
Thiamine (Vitamin B1)
It helps your body turn food into energy and keeps your nerves and muscles working properly.
Pyridoxine (Vitamin B6)
Important for brain function, making red blood cells, and managing mood and sleep by helping produce serotonin and other brain chemicals.
Interaction with Other Medicines
Avoid taking methylcobalamine+ alpha lipoic acid + thiamine + pyridoxine + folic acid with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Interaction with Food Product
Avoid alcohol as it can reduce the effect of folic acid and damage nerves. Cut down on excessive tea or coffee and avoid taking supplements with very high-fiber meals, keep a 1–2 hour gap. Also, avoid raw fish or shellfish, and reduce junk food, as they lower the benefits of these vitamins.
Storage
- The medicine should be stored at room temperature
- Keep away from sunlight and moisture
- Keep away from the reach of children
Intake routine/cycle
Daily dose
Take methylcobalamine + alpha lipoic acid + thiamine + pyridoxine + folic acid exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Recommended Dietary Allowance (RDA)
Methylcobalamin (Vitamin B12)
The recommended dose is 500–1500 mcg per day. Overdosing is rare but may cause acne, rash, or diarrhea.
Folic Acid (Vitamin B9)
The Recommended Dietary Allowance (RDA) for adults is 400 mcg/day. Excess intake may mask Vitamin B12 deficiency and cause digestive upset.
Alpha Lipoic Acid
The recommended dose is 300–600 mg per day. High doses may cause stomach upset, skin rash, or low blood sugar.
Thiamine
The recommended dose is 50 – 100 mg per day. Overdosing may cause headache or irritability.
Pyridoxine
The Recommended Dietary Allowance (RDA) for Vitamin B6 is 1.3 mg/day. overdose may cause nerve damage, numbness, or tingling.
Natural Source of Methylcobalamine + Alpha Lipoic Acid + Thiamine + Pyridoxine + Folic Acid
The following are the natural sources of methylcobalamine+ alpha lipoic acid + thiamine + pyridoxine + folic acid listed in this medicine:
Methylcobalamin (Vitamin B12)
Foods rich in Vitamin B12 include eggs, milk, yogurt, cheese, fish, and chicken.
Folic Acid (Vitamin B9)
Foods rich in folic acid include spinach, methi (fenugreek leaves), broccoli, citrus fruits, and chana (chickpeas).
Alpha Lipoic Acid
Natural sources include spinach, broccoli, tomatoes, peas, and organ meats like liver and heart.
Thiamine
Foods rich in thiamine include whole wheat roti, peanuts, sunflower seeds, rajma (kidney beans)
Pyridoxine (B6)
Foods rich in pyridoxine include bananas, potatoes, chicken, fish, chana (chickpeas)
Methylcobalamine + Alpha Lipoic Acid + Thiamine + Pyridoxine + Folic Acid Summary
Methylcobalamin, alpha lipoic acid, thiamine, pyridoxine, and folic acid are a multivitamin and antioxidant combination used to support nerve health, treat vitamin B deficiencies, and improve overall cellular function. It helps in the management of neuropathic pain (such as in diabetic neuropathy), promotes nerve regeneration, aids in red blood cell formation, boosts energy production, enhances immunity, and protects the body from oxidative stress.
Common side effects may include nausea, stomach upset, headache, dizziness, skin rash, or tingling sensations (with excess Vitamin B6). In rare cases, high doses of Alpha Lipoic Acid may cause low blood sugar. Regular use helps restore essential vitamins, improve nerve function, and maintain overall well-being when taken as prescribed.
FAQ’s
What are some common foods rich in thiamine?
Whole wheat, brown rice, peanuts, sunflower seeds, rajma, moong dal, pork, soybeans, fortified cereals are some common foods which have high thiamine levels.
What are the symptoms of thiamine (Vitamin B1) deficiency?
Common symptoms of thiamine deficiency include tiredness, irritability, poor memory, muscle weakness, loss of appetite, nerve pain, and in severe cases, heart problems.
How does thiamine work in the body?
It helps turn food into energy, supports nerve and muscle function, and keeps the heart healthy.
Folic acid is found in which foods?
Folic acid is found in spinach, methi (fenugreek leaves), broccoli, citrus fruits, and chana (chickpeas).
Can folic acid tablets be taken during pregnancy?
Yes. folic acid tablets are recommended during pregnancy to support the baby’s brain and spine development and to help prevent birth defects.
What are the uses of Alpha Lipoic Acid?
Alpha lipoic acid is used to protect cells from damage, improve nerve health (such as in diabetic neuropathy), boost energy production, and support overall antioxidant defense in the body.
What are the benefits of Alpha Lipoic Acid?
Alpha lipoic acid helps reduce nerve pain, protects cells from damage, improves blood sugar control, supports energy production, and boosts antioxidant levels in the body.
Reference
- Thiamine Dosage Guide + Max Dose, Adjustments [Internet]. Drugs.com. 2024. Available from
- Drug-Nutrient Interactions. Drug-Nutrient Interactions [Internet]. Linus Pauling Institute. 2021. Available from
- Pyridoxine Dosage Guide + Max Dose, Adjustments [Internet]. Drugs.com. Available from
- ApolloPharmacy [Internet]. Apollopharmacy.in. 2019 [cited 2025 Aug 9]. Available from
- CDC. Folic Acid: Sources and Recommended Intake [Internet]. Folic Acid. 2024. Available from
- Saling J. Alpha Lipoic Acid (ALA) [Internet]. WebMD. WebMD; 2010. Available from
- Nguyen H, Gupta V. Alpha-Lipoic Acid [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2021. Available from
- Zhang M, Han W, Hu S, Xu H. Methylcobalamin: A Potential Vitamin of Pain Killer. Neural Plasticity [Internet]. 2013; 2013:1–6. Available from
- National Institutes of Health. Office of Dietary Supplements – Vitamin B12 [Internet]. Nih.gov. National Institutes of Health; 2024. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.