Category- Allopathy
Medicine Highlights
| Uses | 1. To treat fever 2. To treat runny nose and sneezing due to allergies or cold. 3. To treat mild pain like headache, body ache, or throat pain. 4. To treat irritation in the throat associated with cold symptoms. |
| Common Side Effects | 1. Drowsiness or sleepiness 2. Dry mouth or throat 3. Nausea or mild stomach upset 4. Mild headache |
| Additional Information | 1. Take it exactly as prescribed by your doctor. 2. Avoid smoking, as it can reduce the medicine’s effect. 3. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | This medication should be taken orally |
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate Uses
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate are a combination medicine used to reduce inflammation and thinning mucus in the nasal passages and throat in the following conditions:
- Fever
- Runny nose and sneezing
- Mild body pains
- Throat irritation
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate side effects
More Common
- Drowsiness or sleepiness
- Dry mouth or throat
- Nausea or mild stomach upset
- Mild headache
Less Common
- Allergic reactions (rash, itching, swelling)
- Severe dizziness or fainting
- Fast heartbeat
- Liver problems
How Paracetamol + Chlorpheniramine Maleate + Sodium Citrate works
This combination works in three ways: Paracetamol reduces fever and mild pain by acting on the brain’s temperature and pain centers. Chlorpheniramine Maleate (CPM) is an antihistamine that blocks allergy chemicals in the body, helping to reduce sneezing, runny nose, and watery eyes. Sodium Citrate helps thin and loosen mucus in the nose and throat, making it easier to breathe and clear irritation.
Safety Measures and Warning
Allergy
Taking it can cause rash, swelling, or severe breathing problems. Doctor’s advice is important to find a safe alternative.
Severe liver or kidney problems
If you have liver or kidney problems, paracetamol can harm the liver or kidneys further. Your doctor can adjust the dose or recommend a safe option, hence communicate with your doctor about your conditions.
Glaucoma patients
Chlorpheniramine Maleate may increase pressure in the eyes, which can worsen glaucoma. Your doctor must evaluate if it’s safe.
Asthma patients (sensitive to antihistamines)
Chlorpheniramine Maleate can rarely trigger breathing issues. doctor’s supervision is essential to avoid complications.
Pregnant or breastfeeding women
The medicine may affect the fetus and baby’s health, so it should only be taken if your doctor specifically approves.
Children
Safety is not fully established, so a pediatrician must decide the right dose or alternative.
Heart problems or high blood pressure
Chlorpheniramine Maleate can sometimes raise heart rate or blood pressure. A doctor’s guidance is crucial to prevent serious side effects.
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate Interaction with Food Product
Avoid alcohol, limit caffeine and salty foods, and be careful with spicy or oily meals, as they may increase side effects, also they may cause severe drowsiness and sedation as they act on the brain directly.
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate Interaction with Other Medicines
Avoid taking Paracetamol + Chlorpheniramine Maleate + Sodium Citrate with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry) / Chemical name
Paracetamol: N-(4-hydroxyphenyl)acetamide
Chlorpheniramine Maleate: (Z)-but-2-enedioic acid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Sodium Citrate: trisodium;2-hydroxypropane-1,2,3-tricarboxylate
Intake routine/cycle
Daily dose
Take Paracetamol + Chlorpheniramine Maleate + Sodium Citrate exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Do not take more than the prescribed dose of Paracetamol + Chlorpheniramine Maleate + Sodium Citrate. Taking too much can increase the risk of side effects such as drowsiness, nausea, stomach upset, fast heartbeat, or liver problems. If you notice any unusual symptoms or feel unwell after taking the medicine, seek immediate medical attention.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Paracetamol + Chlorpheniramine Maleate + Sodium Citrate Summary
Paracetamol + Chlorpheniramine Maleate (CPM) + Sodium Citrate is a combination medicine used to reduce fever, relieve mild pain, and ease allergy symptoms like runny nose, sneezing, and nasal or throat irritation. Paracetamol lowers fever and reduces pain, CPM blocks allergy reactions to relieve sneezing and runny nose, and Sodium Citrate thins and loosens mucus to help clear congestion and make breathing easier.
Common side effects include drowsiness, dry mouth, mild nausea, or headache, while rare side effects may include allergic reactions, fast heartbeat, or liver problems if overdosed. The medicine should be taken as prescribed, and people with allergies to any ingredient, liver or kidney problems, glaucoma, heart issues, high blood pressure, asthma, pregnancy, breastfeeding, or young children should consult a doctor before use. It can be taken with or after food, and alcohol, excessive caffeine, or very salty/spicy foods should be limited.
FAQ’s
What are the uses for Paracetamol?
Paracetamol is used to reduce fever and relieve mild to moderate pain, such as headache, body ache, toothache, or sore throat.
What are the side effects of Paracetamol?
Paracetamol is usually safe if taken as directed. Sometimes it may cause nausea, stomach upset, or mild rash. Rarely, taking too much can harm the liver or cause serious allergic reactions. If you notice yellowing of the skin or eyes, swelling, or trouble breathing, stop the medicine and see a doctor immediately.
What are the uses for CPM (Chlorpheniramine Maleate)?
CPM is an antihistamine used to treat allergy symptoms such as runny nose, sneezing, watery eyes, itching, and nasal congestion.
What are the side effects of CPM (Chlorpheniramine Maleate)?
CPM is generally safe when taken as prescribed, but it can sometimes cause drowsiness, dry mouth, dizziness, or mild nausea.
What are the uses for Sodium Citrate syrup?
Sodium Citrate syrup is used to thin and loosen mucus in the nose, throat, and chest, making it easier to cough up and clear congestion.
How does Sodium Citrate work?
Sodium Citrate thins and loosens mucus in the nose, throat, and chest. This makes it easier to cough up or clear mucus, helping to relieve congestion and irritation.
Reference
- National Center for Biotechnology Information. Acetaminophen [Internet]. National Library of Medicine. PubChem; 2019. Available from
- PubChem. Chlorpheniramine Maleate [Internet]. Nih.gov. PubChem; 2025 [cited 2025 Oct 4]. Available from
- PubChem. Trisodium citrate [Internet]. Nih.gov. PubChem; 2025. Available from
- DrugBank. Acetaminophen [Internet]. Drugbank Online. 2025. Available from
- Chlorpheniramine maleate | DrugBank Online [Internet]. go.drugbank.com. Available from
- DrugBank. Sodium citrate [Internet]. go.drugbank.com. 2015. Available from
- 1mg.com. Chlorpheniramine Maleate + Phenylephrine + Paracetamol + Sodium Citrate: View Uses, Side Effects and Medicines | 1mg [Internet]. 1mg. 2023 [cited 2025 Oct 4]. Available from
- Paracetamol Phenylephrine cpm sodium citrate Syrup [Internet]. indiamart.com. 2025 [cited 2025 Oct 4]. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.