Category- Allopathy
Medicine Highlights
| Uses | 1. To treat dyspepsia (indigestion) 2. To treat gastroesophageal reflux disease (GERD) 3. To treat irritable bowel syndrome (IBS) 4. To treat anxiety disorders 5. To treat Hallucinations 6. To treat Schizophrenia 7. To treat Vertigo |
| Common Side Effects | 1. Drowsiness 2. Breast tenderness 3. Irregular menstrual periods 4. Constipation 5. Weight gain 6. Unusual tiredness and weakness |
| Additional Information | 1. Avoid driving or any hazardous activity after consuming levosulpiride, as it can cause dizziness or drowsiness. 2. Take this medicine before meals to improve digestion. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children |
| How to Take This Medicine | To be taken orally with a sip of water |
Levosulpiride Uses
Levosulpiride 75 mg is an oral medicine belonging to the category of dopamine antagonists and is used for the following indications:
- Dyspepsia (indigestion)
- Gastroesophageal reflux disease (GERD)
- Irritable bowel syndrome (IBS)
- Anxiety disorders
- Hallucinations
- Schizophrenia
- Vertigo
Levosulpiride side effects
More Common
- Drowsiness
- Breast tenderness
- Irregular menstrual periods
- Constipation
- Weight gain
- Unusual tiredness and weakness
Less Common
- Tremors
- Dystonia
- Akathisia
- Dyskinesia
- Seizures
- Agitation
- Insomnia
- Galactorrhea
- Gynecomastia
- Amenorrhea
- Arrhythmia
- Hypotension
- Photosensitivity
- Pruritus
- Rash
How Levosulpiride works
This medicine works by blocking dopamine, a chemical that slows digestion and affects mood. It helps your stomach move food better and calms overactive brain signals, easing bloating, mild anxiety, and symptoms of depression or psychosis.
Safety Measures and Warning
Pregnancy
The safety of levosulpiride in pregnancy is not established. Inform your doctor if you are pregnant or planning to conceive.
Kidney and Liver Problems
Levosulpiride is known to be safe for use in liver and kidney disease patients.
Past Mental Health Issues
Levosulpiride directly acts on the brain and causes different side effects like sedation, drowsiness, and suicidal thoughts. Inform the doctor about your past mental health issues before using levosulpiride.
Breastfeeding
Levosulpiride is not usually recommended during breastfeeding because there is no reliable information on whether it passes into breast milk or how it might affect a nursing infant.
Heart Problems
Levosulpiride should be used with caution in heart patients, as it can affect blood vessel tone and, in rare cases, affect heart rhythm or blood pressure.
Levosulpiride Interaction with Food Product
Avoid consuming alcohol and smoking simultaneously together, as it may affect the drug’s action and show an effect on the brain, leading to severe drowsiness, sedation, and coma in severe cases.
Levosulpiride Interaction with Other Medicines
Avoid taking Levosulpiride 75 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Levosulpiride Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-methoxy-5-sulfamoylbenzamide
Intake routine/cycle
Daily dose
Take Levosulpiride exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
It is not recommended to take more than 300 mg of Levosulpiride per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Directions for use
- Take Levosulpiride exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking Levosulpiride without your doctor’s approval, even if you feel better.
- If you forget to take Levosulpiride, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
Levosulpiride Summary
Levosulpiride is a medicine used to treat indigestion, bloating, acid reflux, and sometimes mood problems like depression or mild psychosis. It works by calming certain signals in the brain and helping the stomach muscles move food more smoothly. Common side effects include sleepiness, dizziness, and movement issues like shaking or restlessness. It’s best taken before meals and should not be mixed with alcohol. Overdosing, usually above 400 to 600 mg per day, can cause serious problems like confusion, low blood pressure, or seizures. It should be used carefully in the elderly, pregnant women, and people with Parkinson’s or hormone sensitive conditions. Think of it like a traffic controller that helps both your brain and gut run more smoothly, but if overused, it might block important signals too much.
FAQ’s
What are the uses of levosulpiride tablets?
Levosulpiride tablets are used to treat indigestion, bloating, acid reflux, and delayed stomach emptying. They are also prescribed for depression, anxiety, and certain psychotic disorders due to their dopamine-blocking effects.
What are the side effects of levosulpiride tablets?
Levosulpiride tablets may cause drowsiness, dizziness, breast swelling, menstrual changes, or movement issues like tremors. Rarely, it can lead to hormonal imbalances or heart rhythm problems with long-term use.
What is the drug class of levosulpiride?
Levosulpiride belongs to the drug class of calcium channel blockers and can show vascular effects.
What is the highest dose of Levosulpiride?
Levosulpiride is usually prescribed up to 200 mg/day, with 300 mg/day as the upper limit in psychiatric use. Exceeding this increases the risk of side effects, so dosing must always be guided by a physician.
Reference
- Practo. Levosulpiride [Internet]. [cited 2025 Nov 19]. Available from.
- National Center for Biotechnology Information. Levosulpiride [Internet]. PubChem Compound Summary. [cited 2025 Nov 19]. Available from.
- Medicover Hospitals. Levosulpiride Tablet Uses, Side Effects, and Precautions [Internet]. [cited 2025 Nov 19]. Available from.
- Drugs.com. Levosulpiride International Brand Names [Internet]. [cited 2025 Nov 19]. Available from.
Authors
Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.