Category- Allopathy
Medicine Highlights
| Uses | 1. To treat pain and inflammation caused by conditions like osteoarthritis and rheumatoid arthritis. 2. To treat muscle pain and sprains. 3. To treat headache, toothache and dental pain. 4. To treat fever, and pain associated with infections and post-surgical pain |
| Common Side Effects | 1. Stomach discomfort or pain (mild burning or cramps) 2. Nausea or vomiting 3. Diarrhea or constipation 4. Headache or dizziness 5. Mild skin rash or itching 6. Feeling sleepy or tired |
| Additional Information | To keep you safe and healthy, use this medicine only with your doctor’s guidance. |
| Storage | 1- The medicine should be stored at room temperature 2- Keep away from sunlight and moisture 3- Keep away from the reach of children |
| How to Take This Medicine | This medicine is applied on the skin |
Nimesulide + Paracetamol Uses
Nimesulide 100 mg + Paracetamol 325 mg are oral medicines that belongs to the class of NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). It is used to treat:
- Pain and inflammation (swelling and redness) caused by conditions like osteoarthritis or rheumatoid arthritis (joint problems).
- Muscle pain due to strain, sprain, or injury.
- Headaches, including tension headaches and mild migraines.
- Toothache and dental pain.
- Fever and pain associated with infections.
- Pain after surgery or injury (post-surgical or post-traumatic pain).
Directions for use
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
Nimesulide + Paracetamol side effects
More Common
- Stomach discomfort or pain (mild burning or cramps)
- Nausea or vomiting
- Diarrhea or constipation
- Headache or dizziness
- Mild skin rash or itching
- Feeling sleepy or tired
Less Common
- Liver problems (yellowing of eyes/skin, dark urine, fatigue)
- Allergic reactions (swelling of face, lips, tongue, difficulty breathing)
- Severe stomach bleeding or ulcers (black/tarry stools, vomiting blood)
How Nimesulide + Paracetamol works
Nimesulide + Paracetamol is a medicine that helps relieve pain, reduce swelling, and lower fever. Nimesulide works by blocking chemicals in the body that cause pain and inflammation, while Paracetamol works on the brain to reduce pain and bring down fever. Together, they give faster and stronger relief from headaches, toothaches, muscle or joint pain, pain after injury or surgery, and fever, helping you feel more comfortable.
Safety Measures and Warning
Allergic individuals
If you are allergic to Nimesulide or similar painkillers (NSAIDs), taking it can cause rashes, swelling, or breathing problems, which can be dangerous. so, avoid it and tell your doctor immediately
People with stomach problems
Those with stomach ulcers, bleeding, or severe gastritis should avoid it because nimesulide and paracetamol can irritate the stomach lining and worsen bleeding.
People with liver issues
Nimesulide and paracetamol is processed in the liver, so people with liver disease, jaundice, or previous liver problems are at risk of liver damage if they take it.
People with kidney problems
It can affect kidney function, so those with kidney disease should not use it.
People with heart problems
Those with heart disease or history of stroke may face increased risk of heart attack or stroke with nimesulide and paracetamol
Children Under 12 Years
Nimesulide and paracetamol is generally not recommended for young children because safety is not well established.
Pregnant or breastfeeding women
It may harm the developing fetus and baby, so it should only be used if a doctor specifically recommends it.
Nimesulide + Paracetamol Interaction with Other Medicines
Avoid taking Nimesulide + Paracetamol with the following medicines, as it may increase or decrease the desired effect, or in worse cases and it could be fatal:
Nimesulide + Paracetamol Interaction with Food Product
Avoid taking caffeinated food, alcohol and smoking simultaneously as they can cause an increase or decrease in drug action; also, they may cause severe drowsiness and sedation as they act on the brain directly.
Storage
- Store the medicine at room temperature
- Keep away from sunlight and moisture
- Keep out of reach of children
Nimesulide + Paracetamol Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Nimesulide: N-(4-nitro-2-phenoxyphenyl)methane sulfonamide
Paracetamol: N-(4-hydroxyphenyl)acetamide.
Intake routine/cycle
Daily dose
Take Nimesulide + Paracetamol exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Do not take more than the prescribed dose of Nimesulide + Paracetamol in a day, as taking too much can cause severe stomach pain, nausea or vomiting, dizziness, drowsiness, difficulty breathing, liver problems, or even fainting. Always follow your doctor’s instructions and avoid taking extra doses.
Nimesulide + Paracetamol Summary
Nimesulide 100 mg + Paracetamol 325 mg is an oral medicine that helps relieve pain, reduce swelling, and lower fever. Nimesulide works by blocking the chemicals in the body that cause pain and inflammation, while Paracetamol works on the brain to reduce pain and control fever. This combination is commonly used for headaches, toothaches, muscle or joint pain, pain after injury or surgery, and fever caused by infections.
Common side effects include stomach discomfort, nausea, diarrhea, headache, dizziness, mild skin rash, or feeling tired, while rare but serious side effects may involve liver problems, severe stomach bleeding, or allergic reactions. It should not be used by people allergic to its ingredients, those with liver, kidney, heart, or stomach problems, pregnant or breastfeeding women, or children under 12, unless prescribed by a doctor. Always take it with food or milk, do not exceed the prescribed dose, and avoid alcohol to prevent side effects.
FAQ’s
What is Nimesulide + Paracetamol tablet used for?
It is used to relieve pain, reduce swelling, and lower fever. Common uses include headaches, toothaches, muscle or joint pain, pain after injury or surgery, and fever caused by infections.
What are the uses for Nimesulide?
Nimesulide is used to relieve pain, reduce swelling, and lower fever. It helps with headaches, toothaches, muscle pain, joint pain, pain after injuries or surgery, and fever caused by infections.
What are the common side effects of Nimesulide?
Common side effects include stomach pain, nausea, diarrhea or constipation, headache, dizziness, and mild skin rash.
Can I use Nimesulide for headache?
Yes, Nimesulide is often used to relieve headaches, including tension headaches or pain from mild migraines. It works by reducing the chemicals in your body that cause pain and inflammation, helping you feel better.
What is the drug class of Nimesulide?
Nimesulide is a painkiller and anti-inflammatory medicine. It belongs to the NSAID group, which works by reducing the chemicals in your body that cause pain, swelling, and fever.
Reference
- Nimesulide [Internet]. go.drugbank.com. Available from
- PubChem. Nimesulide [Internet]. pubchem.ncbi.nlm.nih.gov. Available from
- Truemeds [Internet]. Truemeds.in. 2019 [cited 2025 Sep 2]. Available from
- 1mg.com. Nimesulide: View Uses, Side Effects and Medicines | 1mg [Internet]. 1mg. 2024 [cited 2025 Sep 2]. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.