Fluconazole 150 mg

Category- Allopathy

Medicine Highlights

Fluconazole Summary 

Fluconazole 150 mg is an antifungal medicine. It works by blocking an enzyme needed to make ergosterol, a key part of the fungal cell membrane. Without ergosterol, the fungus becomes weak and dies. Common side effects include dizziness, fainting, nausea, skin rash, unusual tiredness, vomiting. 

Fluconazole 150 mg should not exceed 800 mg/day. Fluconazole should be avoided by people who are allergic to it, have serious liver problems, or heart rhythm issues. It should be used carefully in those with kidney disease or during pregnancy. Also, avoid it if you’re taking medicines that may interact with it, always consult your doctor first. 

Fluconazole Uses 

Fluconazole 150 mg is an oral medicine belonging to the class of anti-metabolite medicines. It is used to treat following infections: 

1. Vaginal yeast and fungal infection  
2. Skin infections caused by yeast or fungus 
3. Ring-shaped rashes on the body (ringworm) 
4. Rashes in the inner thigh or groin area (jock itch) 
5. Itching or fungal infection of the feet (athlete’s foot)

Directions for use

1. If you forget to take Fluconazole, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose. 
2. Take Fluconazole exactly as prescribed by your doctor, at the same time each day.  
3. Do not stop taking Fluconazole without your doctor’s approval, even if you feel better.

Fluconazole side effects 

More Common  

1. Diarrhea 
2. Dizziness 
3. Fainting 
4. Loss of appetite 
5. Nausea 
6. Skin rash 
7. Unusual tiredness  
8. Vomiting

Less Common

1. Loss of bladder control 
2. Lower back or side pain 
3. Mood changes 
4. Muscle pain or cramps 

How Fluconazole works 

Fluconazole is an antifungal medicine. It blocks an enzyme called 14 demethylase, which is useful to form ergosterol. Ergosterol is an essential part of the fungal cell membrane. Without it, the membrane becomes weak and leaky. This stops the fungus from growing and forming new cells. 

Safety Measures and Warning 

Allergy/Hypersensitivity

If you have ever had an allergy to fluconazole, inform your doctor before they prescribe this medicine. 

Pregnancy

Avoid this medicine if you’re pregnant as this may cause harm to the fetus. Inform your doctor if you are pregnant, planning to become pregnant. 

Electrolyte imbalance or heart disease

Having high or low levels of electrolytes (like potassium or magnesium) or a history of heart disease can increase the risk of heart rhythm problems and may worsen the side effects of this medicine. Always consult your doctor before the treatment 

Liver disease

Liver disease may worsen allergic reactions by reducing the body’s ability to break down and clear medications, leading to increased sensitivity and risk of hypersensitivity. Hence advised not to take this medication 

Kidney disease

If you have kidney disease you should use this medication with caution because the drug may not be properly eliminated from the body, leading to a buildup that can increase the risk of side effects or toxicity. 

Fluconazole Interaction with Other Medicines

Avoid taking Fluconazole with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Fluconazole Interaction with Food Product

Avoid consuming caffeinated foods which can lead to unwanted side effects like allergies and skin rashes. Alcohol and smoking can increase the potential of side effects occurring and worsen the patient’s conditions. 

Storage

1. Store the medicine at room temperature 
2. Keep away from sunlight and moisture 
3. Keep out of reach of children 

Fluconazole Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol 

Intake routine/cycle

Daily dose

Take Fluconazole exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor. 

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage. 

Overdose

Fluconazole should not exceed more than 800 mg/day. This may cause fearfulness, suspiciousness, or other mental changes, auditory and visual hallucinations. Immediate medical support is needed in case of any emergency. 

FAQ’s

1. What are the side effects of fluconazole? 

Fluconazole may cause side effects in some people. Common side effects include headache, nausea, vomiting, stomach pain, diarrhea, and skin rash. Some may also experience dizziness or changes in taste 

2. What are the uses of fluconazole 150 mg ? 

Fluconazole 150 mg is an anti-fungal medicine used to treat infections like brain fungus, mouth/throat fungus, vaginal yeast, urinary fungus, and stomach lining infections. 

3. Can I use fluconazole 150 mg for yeast infection? 

Yes, fluconazole 150 mg is commonly used to treat vaginal yeast infections. In most cases, a single dose (one tablet) is enough to clear the infection. However, it’s best to consult your doctor before taking it 

4. How fast does fluconazole 150 mg work? 

Fluconazole 150 mg usually starts working within 24 hours, but it may take 1 to 3 days for symptoms like itching, burning, or discharge to improve noticeably. 

Reference 

1. Fluconazole (oral route) [Internet]. Mayo Clinic. 2025 [cited 2025 Jul 11]. Available from  
2. DrugBank. Fluconazole [Internet]. Drugbank. 2024. Available from 
3. Govindarajan A, Bistas KG, Aboeed A. Fluconazole [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2024. Available from 
4. PubChem. Fluconazole [Internet]. pubchem.ncbi.nlm.nih.gov. Available from 
5. Fluconazole 150mg caps/PAC-100 [Internet]. Unicef.org. 2018 [cited 2025 Jul 12]. Available from 

Pranathi Chintaluri

Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.