Domperidone 10 mg

Category- Allopathy

Medicine Highlights 

Domperidone Summary

Domperidone 10 mg is taken orally and belongs to the benzimidazole medicines class of medicine. It is approved for the treatment of heartburn, indigestion, and vomiting.

You should take this medicine as instructed by your doctor, either before or after meals or before or after sleep. Side effects of this medicine may include headache and constipation. Do not stop taking this medicine unless advised by your doctor.

Inform your doctor if you are allergic or have a kidney dysfunction, as they may prescribe an alternative medication in such cases.

Domperidone Uses 

Domperidone 10 mg is an oral medicine belonging to the class of benzimidazole medicines. It is used for following indications: 

1. Heart burn 
2. Vomiting 
3. Indigestion 

How Domperidone Work

Domperidone is a medicine that helps move food through the stomach and intestines more quickly. It works by blocking dopamine receptors in the gut, which encourages the muscles in the stomach and intestines to contract. This helps empty the stomach faster and speeds up digestion. 

For nausea and vomiting, domperidone blocks dopamine receptors in a part of the brain (called the chemoreceptor trigger zone) that controls these feelings. 

Direction for use 

1. Take domperidone exactly as prescribed by your doctor, regularly at the same time each day. 
2. Do not stop taking domperidone without your doctor’s approval, even if you feel better. 
3. If you forget to take the medicine, take it as soon as you remember, unless it’s almost time for the next one, then just skip it. 

Domperidone Side Effects

Less Common

1. Loss of balance or muscle control 
2. swelling of the mouth 
3. Breast milk flowing from the nipple 
4. dry mouth 
5. swelling of the breast in the male 
6. headache 
7. hives 
8. hot flashes 
9. itching of skin 
10. itching, redness, pain, or swelling of eye 
11. menstrual irregularities 
12. pain in the breast 

More Common

1. Fast, irregular, pounding, or racing heartbeat or pulse 
2. swelling of face, hands, lower legs, or feet 
3. Change in need to urinate 
4. change in appetite 
5. constipation 
6. diarrhea 
7. burning, difficult, or painful urination 
8. difficulty in speaking 
9. dizziness 
10. drowsiness 
11. heartburn 
12. irritability 
13. lack or loss of strength 
14. leg cramps 
15. mental dullness 
16. nervousness 
17. palpitations 
18. sluggishness 
19. stomach cramps 
20. thirst 
21. tiredness 
22. weakness 

Safety Measure and Warning

Allergy/Hypersensitivity

If you have an allergy to domperidone, inform your doctor immediately to avoid or prevent any complications.

Kidney dysfunction

If you have pre-existing kidney disease, inform your physician, as they may adjust the dose or decide not to prescribe the medication.

Liver disease

Domperidone should be avoided in patients with liver disease, as it can be harmful to the liver.

Domperidone Interaction With Other Medicines

Avoid taking domperidone 10 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal: 

Domperidone Interaction With Food Product

Avoid taking domperidone with grapefruit, grapefruit juice, tobacco, or alcohol, as they may alter the effect of the medication. 

Domperidone Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name- 

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl) propyl]piperidin-4-yl]-1H-benzimidazol-2-one. 

Storage 

1. The medicine should be stored at room temperature  
2. Keep away from sunlight and moisture  
3. Keep away from the reach of children 

Intake Routine/Cycle

Daily Dose

Take domperidone exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed one and continue with your usual schedule. Always consult your doctor before making any changes to your dosage.

Overdose

Overdosing symptoms of domperidone include difficulty in speaking, disorientation, dizziness, fainting, irregular heartbeat, light-headedness, and loss of balance or muscle control. If you know someone who takes domperidone and is experiencing these symptoms, take them to a doctor immediately..

FAQ’s 

1- When should I take domperidone? 

Take this medicine before meals, exactly as your doctor told you. 

2- Can domperidone cause constipation? 

Yes, it has been proven to cause constipation as a side effect.

3- How much domperidone should I take for lactation? 

To enhance milk secretion, you can take 10 mg of domperidone three times a day. Follow the dosage recommended by your doctor. 

4- Which is better, domperidone or ondansetron? 

In a study conducted among children aged 3 months to 5 years, it was found that ondansetron is more effective than domperidone in preventing vomiting. 

5- Why is domperidone preferred over metoclopramide? 

Metoclopramide is a medicine that can enter the brain and cause side effects, while domperidone acts around the stomach and has fewer side effects. 

6- Is domperidone a painkiller? 

No, domperidone is a medicine that prevents vomiting. 

7- Is domperidone used for loose motion? 

Domperidone increases bowel movements and helps the digested food pass through the anus, so it is not used for loose motion. 

8- How does domperidone increase breast milk? 

Domperidone increases the production of breast milk by increasing the level of milk-producing hormone called prolactin.

9- Is domperidone banned in India? 

Domperidone is not banned in India if it is used as a single active ingredient. However, some of its combinations with other medicines are banned in India. 

Reference

1. Hanif H, Jaffry H, Jamshed F, Amreek F, Kumar N, Hussain W, Rizwan A. Oral Ondansetron versus Domperidone for Acute Gastroenteritis Associated Vomiting in Young Children. Cureus. 2019 Sep 12;11(9):e5639. doi: 10.7759/cureus.5639. PMID: 31700742; PMCID: PMC6822884. Available from.
2. The Women’s. Domperidone for increasing breast milk supply. 2019 Feb 26. Available from.
3. Government of Goa. List of banned FDC drugs in Goa. 2024 Aug. Available from.
4. Mayo Clinic. Domperidone (Oral route). Available from.
5. Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Am J Gastroenterol. 2007 Sep;102(9):2036-45. doi: 10.1111/j.1572-0241.2007.01255.x. Epub 2007 May 3. PMID: 17488253. Available from.
6. DrugBank. Domperidone. DrugBank Online. Available from.

Mahak Phartyal

Mahak Phartyal completed her bachelor’s in pharmacy from Veer Madho Singh Bhandari Uttarakhand Technical University. She previously worked as a Medical Writer at Meril Life Sciences, where she wrote numerous scientific abstracts for conferences such as India Live 2024 and the European Society of Cardiology (ESC). During her college years, she developed a keen research interest and published an article titled “Preliminary Phytochemical Screening, Physicochemical and Fluorescence Analysis of Nyctanthes arbor-tristis and Syzygium cumini Leaves.