Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg

Category- Allopathy

About Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg tablet is mainly used to lower high blood pressure and reduce swelling. Doctors prescribe it for kidney stones and to normalize blood pressure. It works by reducing the pressure on heart and helping the body flush out extra salt and water, which eases pressure on blood vessels. Common side effects include frequent urination, dizziness, headache, tiredness, nausea, constipation, low potassium, sensitivity to sunlight, gout, and higher blood sugar. Alcohol, painkillers like NSAIDs, and lithium can interfere with its effect, while a low-salt diet or potassium supplements may be advised. Extra care is needed in older adults and people with diabetes, gout, or liver and kidney problems. Taking too more than 40 mg can be dangerous, causing severe dehydration, very low blood pressure, salt imbalance, and irregular heartbeat that require urgent medical care.

Medicine Highlights

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg Uses

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg is used to prevent high blood pressure and heart attacks.

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg side effects 

More Common

1. Headache 
2. Dizziness 
3. Constipation 
4. Skin rash 
5. Decreased blood pressure 
6. Nausea 

Less Common 

1. Lightheadedness 
2. Palpitations 
3. Oedema (accumulation of water in the tissues) 

How Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg works 

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg is a combination of hydrochlorothiazide and olmesartan. Here hydrochlorothiazide relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Olmesartan slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.

Safety Measures and Warning 

Pregnancy

Pregnant women are not recommended to take Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg, as there are no human studies supporting its safety during pregnancy. In case of an emergency, consult a doctor before using it.

Breastfeeding

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg can pass into breast milk, so it’s used with caution during breastfeeding. Other safer options are usually tried first. If it is needed, the baby should be watched closely for any changes like diarrhea or sleepiness. Always talk to your doctor before using it.

Kidney and Liver Problems

Patients suffering from kidney and liver problems are more prone to kidney and liver damage, as the medicine is converted into a less toxic form in the liver and excreted through the kidney. They may cause interactions and cause severe toxicity, so consult a doctor before using it.

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg Interaction with Food Product 

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg is generally safe with food, and it is recommended to avoid alcohol and smoking with Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg, as they can alter the drug’s effect and may cause severe drowsiness and sedation because of their direct action on the brain.

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg Interaction with Other Medicines  

Avoid taking Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg Chemical Structure

IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name

Hydrochlorothiazide- 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Olmesartan-1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

Intake routine/cycle

Daily dose

Take Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.

Missed Dose

If you forget to take your medicine, take the medication as soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.

Overdose

It is not recommended to take more than 600 mg of this medicine per day, as it may cause severe overdosing effects like extreme drowsiness, confusion, unconsciousness, sweating, double vision, low blood pressure, and slurred speech. Immediately seek medical attention and meet the doctor if necessary.

Storage

1. Store the medicine at room temperature. 
2. Keep away from sunlight and moisture. 
3. Keep out of reach of children 

Directions for use 

1. Take Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg exactly as prescribed by your doctor, at the same time each day. 
2. Do not stop taking this medicine without your doctor’s approval, even if you feel better. 
3. If you forget to take this medicine, take them as soon as you remember. If it’s almost time for your next dose, skip the missed dose.

FAQ’s

What is the mechanism of action of Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg?

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg is a combination of hydrochlorothiazide and olmesartan. Here Amlodipine relaxes and widens blood vessels, making it easier for blood to flow and lowering pressure. Olmesartan slows down the heart rate and reduces the force of pumping, easing strain on the heart. Together, they help control high blood pressure and protect the heart from overwork.

What are the uses of Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg tablets?

Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg are medicines used to treat high blood pressure and chest pain due to poor blood flow to the heart. It helps by relaxing blood vessels and improving circulation, which eases the heart’s workload.

What are the side effects of the Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg tablets?

Common side effects of Olmesartan 5 mg + Hydrochlorothiazide 12.5 mg use include headaches, dizziness, swollen ankles, and sometimes tummy discomfort or skin rashes.

Reference 

1. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–.Hydrochlorothiazide 12.5 mg. Available from. 
2. Cerner Multum. Hydrochlorothiazide 12.5 mg: Uses, Side Effects & Warnings [Internet]. Drugs.com; 2025 Oct 7 [cited 2025 Dec 22]. Available from. 
3. Mayo Clinic Staff. Hydrochlorothiazide 12.5 mg (oral route) [Internet]. Rochester (MN): Mayo Foundation for Medical Education and Research; 2025 Oct 1 [cited 2025 Dec 22]. Available from. 
4. National Center for Biotechnology Information. PubChem Compound Summary for CID 2715, Hydrochlorothiazide 12.5 mg [Internet]. Bethesda (MD): National Library of Medicine; [cited 2025 Dec 22]. Available from. 
5. PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information; 2004–. PubChem Compound Summary for CID 135415867, Olmesartan [cited 2026 Apr 15]. Available from. 
6. Mayo Clinic [Internet]. Olmesartan (oral route). Rochester (MN): Mayo Foundation for Medical Education and Research; c2026 [cited 2026 Apr 15]. Available from. 
7. Drugs.com [Internet]. Olmesartan medoxomil. [cited 2026 Apr 15]. Available from. 

Siva Krishna Adithya Bhumireddy

Siva Krishna Adithya Bhumireddy completed a Bachelor of Pharmacy from GIET School of Pharmacy, affiliated with Andhra University, and from his 3rd year of graduation, he was working as a freelance medical and publication writer. Having expertise in systematic reviews and clinical research. With his keen interest and skills in research and documentation practices, he also reviewed more than 150 manuscripts from international journals like Elsevier, Springer Nature, and Sage Journals, and all the manuscripts were indexed and appeared in PubMed, Scopus, and Web of Science databases, and he received honorary recognition letters and certificates from all of them. Siva Krishna Adithya also published a few systematic, narrative reviews and a few chapters of international expertise.