Category- Allopathy
About Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg is a prescription medicine used to manage certain types of nerve pain (neuropathic pain) when prescribed by a doctor.
Pregabalin works by reducing the release of chemicals involved in pain signaling in the nervous system. Methyl cobalamin is an active form of vitamin B12 that supports normal nerve function. Nortriptyline is a tricyclic antidepressant that can help reduce the transmission of pain signals in the nervous system.
Together, these medicines may help reduce nerve pain and associated symptoms such as burning, tingling, numbness, or shooting pain. Take this medicine only as prescribed by your doctor.
Medicine Highlights
| Uses | 1. To manage nerve (neuropathic) pain 2. To relieve symptoms such as burning, tingling, or shooting pain associated with nerve damage 3. To support nerve health when methyl cobalamin supplementation is required |
| Common Side Effects | 1. Drowsiness or sleepiness 2. Dizziness 3. Dry mouth 4. Constipation 5. Nausea 6. Fatigue or tiredness 7. Blurred vision 8. Headache 9. Difficulty concentrating 10. Increased appetite 11. Weight gain |
| Additional Information | 1. Take this medicine exactly as prescribed by your doctor. 2. This medicine may cause drowsiness or dizziness. Avoid driving or operating machinery until you know how it affects you. 3. Avoid alcohol while taking this medicine, as it may increase drowsiness and dizziness. 4. Do not stop taking this medicine suddenly without consulting your doctor. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children. |
| How to Take This Medicine | Take this medicine orally with a sip of water |
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg Uses
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg is mainly used to manage neuropathic pain, which occurs due to damage or irritation of nerves.
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg side effects
More Common
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Nausea
- Fatigue
- Blurred vision
- Headache
- Difficulty concentrating
- Increased appetite
- Weight gain
Less Common
- Severe allergic reaction with swelling of the face, lips, tongue, or throat
- Severe dizziness or fainting
- Difficulty breathing
- Severe confusion or unusual changes in behaviour
- Severe muscle weakness
- Persistent blurred vision or significant changes in eyesight
- Fast or irregular heartbeat
- Difficulty passing urine
- Severe constipation
- Thoughts of self-harm or suicide
How Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg works
This medicine contains three medicines that work differently. Pregabalin reduces the release of certain chemicals involved in pain signaling, which helps reduce abnormal nerve activity.
Methyl cobalamin is a form of vitamin B12 that supports normal nerve function. Nortriptyline changes the levels of certain chemical messengers in the nervous system and helps reduce the transmission of pain signals. Together, these medicines help reduce nerve pain and related symptoms.
Safety Measures and Warning
Allergy or Hypersensitivity
If you are allergic to escitalopram, clonazepam, or any ingredient in this medicine, tell your doctor before taking it. An allergic reaction may cause rash, swelling, or difficulty breathing.
Kidney problems
If you have kidney disease, tell your doctor before taking this medicine. Pregabalin is mainly removed from the body through the kidneys, and your doctor may need to adjust the dose.
Heart problems
If you have heart disease or a history of abnormal heart rhythm, tell your doctor before taking this medicine. Nortriptyline may affect heart rhythm in some people.
Glaucoma
If you have glaucoma, tell your doctor before taking this medicine. Nortriptyline may increase pressure inside the eye in susceptible people.
Urination problems
If you have difficulty passing urine or have an enlarged prostate, tell your doctor before taking this medicine. Nortriptyline may make these problems worse.
Seizures
If you have a history of seizures or epilepsy, tell your doctor before taking this medicine. Pregabalin is used for certain seizure disorders, but the dose and use should be determined by your doctor.
Mental health changes
Tell your doctor if you experience unusual mood or behavior changes, worsening depression, severe agitation, or thoughts of self-harm during treatment.
Swelling
Pregabalin may cause swelling of the hands, feet, or legs. Tell your doctor if you develop significant or persistent swelling.
Breathing problems
Tell your doctor if you have a breathing disorder or take other medicines that cause drowsiness. Pregabalin may increase the risk of serious breathing problems when combined with certain central nervous system depressants.
Dependence and Withdrawal
Pregabalin may cause physical dependence in some people, particularly with prolonged use. Do not stop taking it suddenly. Your doctor may gradually reduce the dose when treatment is stopped.
Pregnancy and Breastfeeding
Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medicine. Your doctor will decide whether this medicine is appropriate for you.
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg Interaction with Food Product
There are no major food restrictions with this medicine. Try to take the medicine at the same time each day to maintain a regular routine.
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg Interaction with Other Medicines
Avoid taking Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Pregabalin: (3S)-3-(aminomethyl)-5-methylhexanoic acid
Nortriptyline: N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
Intake routine/cycle
Daily dose
Take Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take your medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Taking more than the prescribed amount may cause excessive sleepiness, dizziness, confusion, blurred vision, or difficulty breathing. If you have taken more than the recommended dose, contact your doctor or seek immediate medical attention.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What are the common brand names for pregabalin, methyl cobalamin, and nortriptyline in India?
This combination is available in India under several prescription brand names, including Preganerv NT, Nurokind-NT, Maxgalin NT, Pregalin NT, and other brands marketed by different pharmaceutical companies. The active ingredients remain the same, but the brand may vary depending on the manufacturer.
Where can I buy pregabalin, methyl cobalamin, and nortriptyline online with home delivery in India?
Pregabalin + Methyl cobalamin + Nortriptyline is a prescription medicine and should be used only under a doctor’s supervision. You can order it from SayaCare, which provides medicine delivery across India. A valid prescription is required before dispensing this medicine.
What are the common side effects of a medication containing pregabalin, methylcobalamin, and nortriptyline?
Common side effects include drowsiness, dizziness, dry mouth, constipation, nausea, headache, fatigue, blurred vision, increased appetite, and weight gain. These side effects are usually mild and may improve as your body adjusts to the medicine. Contact your doctor if they become severe or do not go away.
How should a combination of nerve pain treatment be dosed for maximum effectiveness?
Take the medicine exactly as directed by your doctor and continue the treatment for the prescribed duration, even if your symptoms improve. Taking it regularly at the same time each day helps maintain consistent medicine levels in the body. Do not take extra tablets if you miss a dose, and do not stop treatment without consulting your doctor.
How do pregabalin, methyl cobalamin, and nortriptyline work together in treating nerve pain?
Pregabalin helps reduce abnormal nerve pain signals, methyl cobalamin supports nerve repair and healthy nerve function, and nortriptyline helps reduce the transmission of pain signals in the nervous system. Together, they help relieve symptoms such as burning, tingling, numbness, and shooting nerve pain.
What are the best practices for taking a combination of medications for nerve pain?
Take Pregabalin + Methyl cobalamin + Nortriptyline exactly as prescribed by your doctor. Take it at the same time each day and do not change the dose or stop it suddenly. Avoid alcohol, as it may increase drowsiness and dizziness. Do not drive if you feel sleepy or dizzy.
What are the recommended dosages for pregabalin, methyl cobalamin, and nortriptyline?
The dosage depends on your condition, age, kidney function, and response to treatment. Your doctor will decide on the appropriate dose. The commonly prescribed strength of this combination is Pregabalin 75 mg + Methyl cobalamin 1500 mcg + Nortriptyline 10 mg. Do not change the dose without your doctor’s advice.
What are the potential drug interactions with Pregabalin + Methyl cobalamin + Nortriptyline?
This medicine may interact with opioid painkillers, sleeping pills, medicines that cause drowsiness, certain antidepressants, and alcohol. These combinations may increase drowsiness, dizziness, or breathing problems. Tell your doctor about all the medicines and supplements you take.
Where can I buy Pregabalin + Methylcobalamin + Nortriptyline online with home delivery in India?
This is a prescription medicine and should be taken only under a doctor’s supervision. You can order it from SayaCare, which provides home delivery of medicines across India. A valid prescription is required before dispensing the medicine.
Reference
- PubChem. PubChem [Internet]. Nih.gov. PubChem; 2026 [cited 2026 Aug 31]. Available from
- PubChem. Pregabalin [Internet]. Nih.gov. PubChem; 2025 [cited 2026 Aug 31]. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.