Category- Allopathy
About Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg
This medicine contains diclofenac, paracetamol, and chlorzoxazone. This medicine is used to relieve pain, inflammation, swelling, and muscle spasms associated with conditions such as back pain, neck pain, muscle strain, sprains, sports injuries, joint pain, and painful musculoskeletal disorders.
Diclofenac reduces pain and inflammation; paracetamol helps relieve pain and fever, while chlorzoxazone relaxes tight and painful muscles. Together, they provide effective relief from pain along with muscle relaxation.
It is best taken with or after food to reduce stomach irritation. Avoid alcohol while taking this medicine because it may increase drowsiness, stomach bleeding, and liver damage. People with stomach ulcers, severe liver or kidney disease, heart disease, allergy to painkillers, muscle disorders, or breathing problems should consult their doctor before using this medicine.
Medicine Highlights
| Uses | 1. To treat muscle pain and muscle spasms 2. To treat back pain and neck pain 3. To treat joint pain 4. To treat sprains and strains 5. To treat sports injury pain 6. To treat painful muscle stiffness 7. To treat post-surgery pain and muscle spasms |
| Common Side Effects | 1. Nausea 2. Vomiting 3. Stomach pain 4. Heartburn / acidity 5. Dizziness 6. Drowsiness 7. Weakness 8. Loss of appetite |
| Additional Information | 1. Take it exactly as prescribed by your doctor. 2. Avoid smoking, as it can reduce the effect of medicine. 3. Inform your doctor if you have heart, liver, or kidney problems. |
| Storage | 1. The medicine should be stored at room temperature. 2. Keep away from sunlight and moisture. 3. Keep away from the reach of children. |
| How to Take This Medicine | Take this medication orally with a sip of water. |
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg Uses
Diclofenac 50 mg + Paracetamol 325 mg + Chlorzoxazone 500 mg tablet is used to treat the following conditions:
- Muscle pain and spasms
- Back pain and Neck pain
- Joint pain
- Sprains and strains
- Sports injury pain
- Painful muscle stiffness
- Post-surgery pain with muscle spasms
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg side effects
More Common
- Severe stomach pain
- Black stools or blood in stools
- Vomiting blood
- Yellow eyes or yellow skin (possible liver problem)
- Difficulty breathing
- Swelling of face, lips, or throat
- Severe allergic skin rash
- Extreme drowsiness or confusion
Less Common
- Nausea
- Vomiting
- Stomach upset
- Heartburn
- Dizziness
- Sleepiness
- Weakness
- Loss of appetite
How Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg works
This medicine contains ingredients like diclofenac, paracetamol, and chlorzoxazone. Diclofenac blocks the production of prostaglandins, which cause pain and inflammation. Paracetamol reduces pain and fever by acting on the brain’s pain and temperature control center. Chlorzoxazone acts on the central nervous system to relax tight muscles and reduce painful muscle spasms. Together, they provide effective relief from pain, inflammation, and muscle stiffness.
Safety Measures and Warning
Allergy or Hypersensitivity
People who are allergic to diclofenac, paracetamol, chlorzoxazone, or any other ingredient of this medicine should not take it without consulting a doctor, as it may cause severe allergic reactions.
Liver Problems
Consult your doctor before taking this medicine if you have liver disease because both paracetamol and chlorzoxazone may increase the risk of liver damage.
Kidney Problems
People with kidney disease should consult their doctor before using this medicine because diclofenac may worsen kidney function.
Heart Problems
If you have heart disease or high blood pressure, consult your doctor before taking this medicine because diclofenac may increase the risk of heart-related complications.
Stomach Ulcer or Bleeding
People with stomach ulcers or a history of stomach bleeding should use this medicine only under medical supervision because diclofenac can increase the risk of bleeding.
Asthma
People who have asthma triggered by painkillers should consult their doctor before taking this medicine because it may worsen breathing problems.
Pregnancy
Consult with your doctor before taking this medicine during pregnancy. It is generally not recommended during the last three months of pregnancy.
Breastfeeding
Consult your doctor before taking this medicine while breastfeeding because small amounts of the medicine may pass into breast milk.
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg Interaction with Food Product
Take this medicine after food to reduce stomach irritation. Avoid alcohol because it can increase drowsiness, stomach bleeding, and liver damage. Heavy or oily meals may increase stomach discomfort in some people.
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg Interaction with Other Medicines
Avoid taking this medicine with the following medicines, as it may increase or decrease the desired effect, or in worse cases, it could be fatal:
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg Chemical Structure
IUPAC (International Union of Pure and Applied Chemistry)/ Chemical name
Diclofenac: 2-[2-(2,6-dichloroanilino) phenyl]acetic acid
Paracetamol – N-acetyl-para-aminophenol (APAP), acetaminophen
Chlorzoxazone: 5-chloro-3H-1,3-benzoxazol-2-one
Intake routine/cycle
Daily dose
Take this medicine exactly as your doctor recommends. The dose may change based on your condition and how well you respond. Do not take more than prescribed without consulting your doctor.
Missed Dose
If you forget to take this medicine, take the medication soon as you remember. If it’s nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult the doctor before making any changes to your dosage.
Overdose
Taking more than the prescribed dose may cause severe drowsiness, nausea, vomiting, stomach bleeding, liver damage, confusion, difficulty breathing, or unconsciousness. Seek immediate medical attention if an overdose is suspected.
Storage
- Store the medicine at room temperature.
- Keep away from sunlight and moisture.
- Keep out of reach of children
Directions for use
- Take this medicine exactly as prescribed by your doctor, at the same time each day.
- Do not stop taking this medicine without your doctor’s approval, even if you feel better.
- If you forget to take this medicine, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose.
FAQ’s
What are the uses of Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet?
Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet is used to treat muscle pain, muscle spasms, back pain, neck pain, joint pain, sprains, strains, sports injuries, and painful muscle stiffness. It helps reduce pain, inflammation, and relaxes tight muscles.
Can I take Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet after food?
Yes. It is recommended to take this medicine after food to reduce the risk of stomach irritation and acidity. Follow your doctor’s instructions regarding the dose.
Does Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet cause drowsiness?
Yes. Chlorzoxazone may cause drowsiness, dizziness, or sleepiness in some people. Avoid driving or operating heavy machinery until you know how the medicine affects you.
Can I drink alcohol while drinking Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet?
No. Alcohol should be avoided while taking this medicine because it can increase drowsiness and raise the risk of stomach bleeding and liver damage.
How long should I take Diclofenac 50 mg, Paracetamol 325 mg, Chlorzoxazone 500 mg tablet?
Take this medicine only for the duration prescribed by your doctor. Do not continue using it for longer than recommended, as prolonged use may increase the risk of side effects such as stomach, liver, or kidney problems.
Reference
- Drugs.com. Paracetamol [Internet]. 2024 [cited 2024 Nov 28]. Available from
- Diclofenac (Oral Route) Description and Brand Names – Mayo Clinic [Internet]. Available from
- Alfaro RA, Modi PV. Diclofenac [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from
- NHS. About paracetamol for adults [Internet]. nhs.uk. 2022. Available from
- PubChem. Chlorzoxazone [Internet]. Nih.gov. PubChem; 2026. Available from
- PubChem. Diclofenac [Internet]. @pubchem. PubChem; 2020. Available from
Authors
Pranathi is a final year Pharm D student at Chalapathi Institute of Pharmaceutical Sciences. She loves learning and applying her knowledge in pharmacy and has a passion for writing, which allows her to express ideas clearly and creatively. She enjoys combining her technical skills with her love for writing and communication to make a meaningful impact. Currently she is working on a research paper about “Consanguineous marriages and its impact on children’s health” which will be published by the end of 2025.